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Novel insights into auditory cortex function using bilateral simultaneous transcranial imaging

Research Project

Project/Area Number 23390395
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionNiigata University

Principal Investigator

TAKAHASHI Sugata  新潟大学, 医歯学系, 教授 (10154824)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Kuniyuki  新潟大学, 医歯学系, 助教 (40452057)
KUBOTA Yamato  新潟大学, 医歯学総合病院, 助教 (40547593)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Keywords両耳聴 / 大脳聴覚野 / イメージング / マウス / フラビン蛋白蛍光
Research Abstract

Binaural hearing, unlike unilateral hearing, enables the recognition of the sound location, and the improvement of hearing ability under conditions of ambient noise. Until recently, in research on the auditory cortex, technical challenges had made it difficult to present sounds to each ear separately and conduct studies differentiating left and right auditory cortices. We have improved the fluorescence microscope that we have been using, and we have recorded the responses of the bilateral auditory cortex simultaneously. Furthermore, we have developed a device capable of stimulating each ear separately. Although the conventional thinking is that the auditory cortex contralateral to the stimulus processes the response, we in fact found that much of the processing also occurs ipsilaterally. We also found that bilateral stimulation evokes a different response from that of unilateral stimulation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (28 results)

All 2013 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (26 results) Remarks (1 results)

  • [Journal Article] Auditory cortical areas activated by slow frequency-modulated sounds in mice2013

    • Author(s)
      Honma Y, Tsukano H, Horie M, Ohshima S, Tohmi M, Kubota Y, Takahashi K, Hishida R, Takahashi S, Shibuki K
    • Journal Title

      PLOS ONE

      Volume: 8(7)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] マウス聴覚野のOFF応答のイメージング解析2013

    • Author(s)
      馬場洋徳, 本間悠介, 高橋邦行, 大島伸介, 窪田和, 澁木克栄, 髙橋姿
    • Organizer
      第10回側頭骨疾患研究会
    • Place of Presentation
      第一ホテル東京, 東京都港区
    • Year and Date
      2013-01-08
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス聴覚・視覚連想記憶のM字迷路による解析2013

    • Author(s)
      山岸達矢, 馬場洋徳, 本間悠介, 大島伸介, 窪田和, 高橋邦行, 澁木克栄, 髙橋姿
    • Organizer
      第18回聴覚研究フォーラム
    • Place of Presentation
      同志社びわこリトリートセンター, 滋賀県大津市
    • Related Report
      2013 Final Research Report
  • [Presentation] Cortical depression in the mouse auditory cortex after sound discrimination learning2013

    • Author(s)
      Shinsuke Ohshima, Kuniyuki Takahashi, Tatsuya Yamagishi, Hironori Baba, Yuusuke Honma, Hiroaki Tsukano, Yamato Kubota, Ryuichi Hishida, Katsuei Shibuki, Sugata Takahashi
    • Organizer
      29th politzer society meeting
    • Place of Presentation
      Susesi Resort- Antalya, Turkey
    • Related Report
      2013 Final Research Report
  • [Presentation] Bilateral functional differences in the mouse auditory cortex using flavoprotein autofluorescence imaging2013

    • Author(s)
      Kuniyuki Takahashi, Hironori Baba, Yuusuke Honma, Shinsuke Ohshima, Yamato Kubota, and Sugata Takahashi
    • Organizer
      2nd meeting of EA ORL-HNS and CE ORL-HNS
    • Place of Presentation
      Nice Acropolis, Nice, France
    • Related Report
      2013 Final Research Report
  • [Presentation] Bilateral functional differences in the mouse auditory cortex using flavoprotein autofluorescence imaging2013

    • Author(s)
      高橋邦行、馬場洋徳、本間悠介、大島伸介、窪田和、高橋姿
    • Organizer
      2nd meeting of EA ORL-HNS and CE ORL-HNS
    • Place of Presentation
      ニース(フランス)
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス聴覚野OFF応答のイメージング2012

    • Author(s)
      馬場洋徳, 塚野浩明, 本間悠介, 大島伸介, 窪田和, 高橋邦行, 菱田竜一, 髙橋姿, 澁木克栄
    • Organizer
      第19回みかんの会
    • Place of Presentation
      有壬記念館 新潟市
    • Year and Date
      2012-10-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 先行持続刺激により出現する マウス聴覚野の二相性応答パターン2012

    • Author(s)
      馬場 洋徳, 本間 悠介, 大島 伸介, 窪田和, 高橋邦行, 澁木克栄, 髙橋姿
    • Organizer
      第57回日本聴覚医学会総会
    • Place of Presentation
      国立京都国際会館 京都市
    • Year and Date
      2012-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Biphasic ON-OFF responses in the mouse auditory cortex appeared after exposure to sustained tone bursts2012

    • Author(s)
      馬場洋徳, 塚野浩明, 本間悠介, 大島伸介, 窪田和, 高橋邦行, 菱田竜一, 髙橋姿, 澁木克栄
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場, 名古屋市
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 先行持続音刺激によって出現するマウス聴覚野OFF応答2012

    • Author(s)
      馬場洋徳, 塚野浩明, 本間悠介, 髙橋姿, 澁木克栄
    • Organizer
      第1回基礎・臨床研究交流会
    • Place of Presentation
      新潟大学医学部, 新潟市
    • Year and Date
      2012-09-05
    • Related Report
      2013 Final Research Report
  • [Presentation] フラビン蛋白蛍光イメージングを用いた大脳聴覚野の研究2012

    • Author(s)
      高橋邦行, 大島伸介, 窪田和, 本間悠介, 馬場洋徳, 髙橋姿, 塚野浩明, 菱田竜一, 澁木克栄
    • Organizer
      第1回基礎・臨床研究交流会
    • Place of Presentation
      新潟大学医学部, 新潟市
    • Year and Date
      2012-09-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 先行音刺激によって出現するマウス聴覚野のOFF反応2012

    • Author(s)
      馬場洋徳, 塚野浩明, 本間悠介, 大島伸介, 窪田和, 高橋邦行, 菱田竜一, 髙橋姿, 澁木克栄
    • Organizer
      脳研夏期セミナー
    • Place of Presentation
      新潟大学脳研究所, 新潟市
    • Year and Date
      2012-08-04
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス大脳聴覚野の周波数変調(FM)音処理機構2012

    • Author(s)
      本間悠介, 高橋邦行, 塚野浩明, 堀江正男, 馬場洋徳, 大島伸介, 窪田和, 澁木克栄, 髙橋姿
    • Organizer
      第113回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      朱鷺メッセ, 新潟市
    • Year and Date
      2012-05-10
    • Related Report
      2013 Final Research Report
  • [Presentation] ON and OFF responses in the mouse auditory cortex after exposure to long-lasting tone bursts2012

    • Author(s)
      馬場洋徳, 塚野浩明, 本間悠介, 大島伸介, 窪田和, 高橋邦行, 菱田竜一, 髙橋姿, 澁木克栄
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館, 松本市
    • Year and Date
      2012-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] ON and OFF responses in the mouse auditory cortex after exposure to long-lasting tone bursts2012

    • Author(s)
      馬場洋徳, 塚野浩明, 本間悠介, 大島伸介, 窪田和, 高橋邦行, 菱田竜一, 高橋姿, 澁木克栄
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館(松本市)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 大脳聴覚野研究の現状とススメ-臨床医の立場から-2012

    • Author(s)
      高橋邦行
    • Organizer
      第14回新潟耳鼻咽喉科臨床懇話会
    • Place of Presentation
      ホテルイタリア軒, 新潟市
    • Year and Date
      2012-02-25
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス大脳聴覚野におけるFM音情報処理領域2012

    • Author(s)
      本間悠介, 高橋邦行, 塚野浩明, 堀江正男, 馬場洋徳, 大島伸介, 窪田和, 澁木克栄, 髙橋姿
    • Organizer
      第10回側頭骨疾患研究会
    • Place of Presentation
      ホテルメトロポリタン仙台, 仙台市
    • Year and Date
      2012-01-07
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス大脳聴覚野におけるFM音情報処理領域2012

    • Author(s)
      本間悠介, 高橋邦行, 塚野浩明, 堀江正男, 馬場洋徳, 大島伸介, 窪田和, 澁木克栄, 高橋姿
    • Organizer
      第10回側頭骨疾患研究会
    • Place of Presentation
      ホテルメトロポリタン仙台(仙台市)
    • Year and Date
      2012-01-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Special Lecture : New imaging techniques of the central auditory system2011

    • Author(s)
      Sugata Takahashi
    • Organizer
      11th Japan-Taiwan Conference on Otolaryngology - Head and Neck Surgery
    • Place of Presentation
      ANA クラウンプラザホテル神戸, 神戸市
    • Year and Date
      2011-12-08
    • Related Report
      2013 Final Research Report
  • [Presentation] ON and OFF responses in the mouse auditory cortex disclosed after sound exposure2011

    • Author(s)
      馬場洋徳, 塚野浩明, 本間悠介, 大島伸介, 窪田和, 高橋邦行, 菱田竜一, 髙橋姿, 澁木克栄
    • Organizer
      第16回聴覚研究フォーラム
    • Place of Presentation
      同志社びわこリトリートセンター, 大津市
    • Year and Date
      2011-12-03
    • Related Report
      2013 Final Research Report
  • [Presentation] ON and OFF responses in the mouse auditory cortex disclosed after sound exposure2011

    • Author(s)
      馬場洋徳, 塚野浩明, 本間悠介, 大島伸介, 窪田和, 高橋邦行, 菱田竜一, 高橋姿, 澁木克栄
    • Organizer
      第16回聴覚研究フォーラム
    • Place of Presentation
      同志社びわこリトリートセンター(大津市)
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス大脳聴覚野のFM音方向選択性領域2011

    • Author(s)
      本間悠介, 高橋邦行, 大島伸介, 窪田和, 澁木克栄, 髙橋姿
    • Organizer
      第9回側頭骨疾患研究会
    • Place of Presentation
      新潟グランドホテル, 新潟市
    • Year and Date
      2011-01-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 先行持続音刺激によって出現するマウス聴覚野OFF応答

    • Author(s)
      馬場洋徳, 塚野浩明, 本間悠介, 髙橋姿, 澁木克栄
    • Organizer
      第1回基礎・臨床研究交流会
    • Place of Presentation
      新潟市
    • Related Report
      2012 Annual Research Report
  • [Presentation] フラビン蛋白蛍光イメージングを用いた大脳聴覚野の研究

    • Author(s)
      高橋邦行, 窪田和, 大島伸介, 本間悠介, 馬場洋徳, 髙橋姿, 塚野浩明, 菱田竜一, 澁木克栄
    • Organizer
      第1回基礎・臨床研究交流会
    • Place of Presentation
      新潟市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Biphasic ON-OFF responses in the mouse auditory cortex appeared after exposure to sustained tone bursts

    • Author(s)
      馬場洋徳, 塚野浩明, 本間悠介, 大島伸介, 窪田和, 高橋邦行, 菱田竜一, 髙橋姿, 澁木克栄
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 先行持続刺激により出現する マウス聴覚野の二相性応答パターン

    • Author(s)
      馬場 洋徳, 本間 悠介, 大島 伸介, 窪田 和, 高橋 邦行, 澁木克栄, 髙橋 姿
    • Organizer
      第57回日本聴覚医学会総会
    • Place of Presentation
      京都市
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス聴覚野OFF応答のイメージング解析

    • Author(s)
      馬場洋徳, 本間悠介, 大島伸介, 窪田和, 高橋邦行, 澁木克栄, 髙橋姿
    • Organizer
      第11回側頭骨疾患研究会
    • Place of Presentation
      東京都
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.niigata-u.ac.jp/oto/about/research/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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