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The role of intrinsic immunity for EBV-mediated nasopharyngeal carcinogenesis

Research Project

Project/Area Number 23390396
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKanazawa University

Principal Investigator

YOSHIZAKI Tomokazu  金沢大学, 医学系, 教授 (70262582)

Co-Investigator(Kenkyū-buntansha) SUGIMOTO Hisashi  金沢大学, 附属病院, 講師 (20547179)
WAKISAKA Naohiro  金沢大学, 附属病院, 講師 (70377414)
KONDO Satoru  金沢大学, 附属病院, 助教 (70436822)
ENDO KAzuhira  金沢大学, 附属病院, 助教 (30547154)
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords上咽頭癌 / Epstein-Barr ウイルス / 内因性免疫 / 中咽頭癌 / ヒトパピローマウイルス / APOBEC / EBV / 内陰性免疫
Outline of Final Research Achievements

Intrinsic immunity, including APOBEC family, is a defense system inherent to a cell itself. Viral oncogenesis by EBV, HPV has been a matter of issue these days. We identified that APOBEC3G was overexpressed in both EBV-pisitive nasopharyngeal cancer and HPV-positive oropharyngeal cancer tissues. Moreover, APOBEC specific G to A, C to T mutations were frequently detected in HPV-E2 region. These results suggest that intrinsic immunity, especially, APOBEC3G, is associated with HPV-mediated oropharyngeal oncogenesis.

Report

(4 results)
  • 2014 Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (23 results)

All 2013 2012 2011

All Journal Article (11 results) (of which Peer Reviewed: 8 results) Presentation (12 results) (of which Invited: 1 results)

  • [Journal Article] 特集●図でみる免疫学のABC● 腫瘍と免疫 腫瘍に関する免疫療法、モノクローナル抗体療法2013

    • Author(s)
      吉崎 智一
    • Journal Title

      JOHNS

      Volume: 29 Pages: 465-468

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 上咽頭癌診断治療の進歩 ―EBウイルス発見から半世紀間の歩み―2013

    • Author(s)
      吉崎 智一
    • Journal Title

      日本耳鼻咽喉科学会会報

      Volume: 116 Pages: 1175-1184

    • NAID

      130003395243

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oncological and functional outcome after transoral 532-nm pulsed potassium-titanyl-phosphate laser surgery for T1a glottic carcinoma.2013

    • Author(s)
      Murono S
    • Journal Title

      Lasers Med Sci.

      Volume: 28 Pages: 615-619

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 上咽頭癌とEBM2012

    • Author(s)
      吉崎智一
    • Journal Title

      JOHNS

      Volume: 28 Pages: 202-204

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Journal Article] Current understanding and management of nasopharyngeal carcinoma.2012

    • Author(s)
      Yoshizaki T
    • Journal Title

      Auris Nasus Larynx

      Volume: 39 Pages: 137-144

    • NAID

      120003959461

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of lymphangiogenesis through vascular endothelial growth factor-C/vascular endothelial growth factor receptor 3 axis and its correlation with lymph node metastasis in nasopharyngeal carcinoma.2012

    • Author(s)
      Wakisaka N
    • Journal Title

      Oral Oncol.

      Volume: 48 Pages: 703-708

    • NAID

      120003959476

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymphangiogenesis in regional lymph nodes predicts nodal recurrence in pathological N0 squamous cell carcinoma of the tongue.2012

    • Author(s)
      Hirota K
    • Journal Title

      Histopathology

      Volume: 61 Pages: 1065-1071

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current understanding and management of nasopharyngeal carcinoma2012

    • Author(s)
      Yoshizaki T, Ito M, Murono S, Wakisaka N, Kondo s, Endo K
    • Journal Title

      Auris Nasus Larynx

      Volume: 39 Pages: 137-144

    • NAID

      120003959461

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel immune evasion mechanism of LMP-1, an EBV-primary oncogene, in nasopharyngeal carcinoma2011

    • Author(s)
      Yoshizaki T
    • Journal Title

      Adv Otorhinolaryngol

      Volume: 72 Pages: 157-159

    • NAID

      120003479722

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 手術手技OPE私が愛用する手術器具91血管鉤・神経鉤2011

    • Author(s)
      吉崎智一
    • Journal Title

      JOHNS

      Volume: 27 Pages: 1093-2011

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 和漢診療外来耳鼻咽喉科から漢方のエビデンスを発信したい2011

    • Author(s)
      吉崎智一、小川恵子
    • Journal Title

      漢方と診療

      Volume: 2 Pages: 78-82

    • Related Report
      2011 Annual Research Report
  • [Presentation] Alternating Chemoradiotherapy In Patients With Advanced Nasopharyngeal Carcinoma. -prospective multicenter phase IIstudy-2013

    • Author(s)
      Yoshizaki T, Wakisaka N, Murono S, Endo K, Tsuji A, Fuwa N
    • Organizer
      6th International Symposium on Nasopharyngeal Carcinoma
    • Place of Presentation
      Istanbul,Turkey
    • Related Report
      2013 Annual Research Report
  • [Presentation] Superselective intra‐arterial chemoradiotherapy2013

    • Author(s)
      Yoshizaki T
    • Organizer
      The Eurasian Federation of Oncology (EAFO) III Eurasian Forum on Head & Neck Cancer
    • Place of Presentation
      St. Petersburg,Russian
    • Related Report
      2013 Annual Research Report
  • [Presentation] パネルディスカッション:咽頭癌診断治療のパラダイムシフト2013

    • Author(s)
      吉崎智一
    • Organizer
      第26回日本口腔・咽頭科学会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] Factors that affect an efficacy of superselective intraarterial chemoradiotherapy for maxillary sinus cancer2012

    • Author(s)
      Yoshizaki T
    • Organizer
      24th Congress of the European Rhinologic Society 31st International Symposium of Infection & Allergy
    • Place of Presentation
      Toulouse, France
    • Related Report
      2012 Annual Research Report
  • [Presentation] Concurrent intra-arterial chemotherapy and radiotherapy for advanced laryngeal cancer2012

    • Author(s)
      Yoshizaki T
    • Organizer
      9th ELS Congress 2012
    • Place of Presentation
      Helsink, Finland
    • Related Report
      2012 Annual Research Report
  • [Presentation] 喉頭乳頭腫とシドフォビル注入療法2012

    • Author(s)
      吉崎智一
    • Organizer
      第64回日本気管食道科学会
    • Place of Presentation
      東京 ホテル日航東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The role of EBV in nasopharyngeal carcinoma. How far have we grasped?2011

    • Author(s)
      Yoshizaki T
    • Organizer
      11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
    • Place of Presentation
      ANA CROWNE PLAZA KOBE(神戸市)(シンポジスト/招待講演)
    • Year and Date
      2011-12-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 鼻副鼻腔癌の切除と再建2011

    • Author(s)
      吉崎智一
    • Organizer
      第50回日本鼻科学会
    • Place of Presentation
      岡山コンベンションセンター(岡山市)(パネリスト/招待講演)
    • Year and Date
      2011-12-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 側頭骨悪性腫瘍-手術vs化学放射線法超選択的動注化学療法による側頭骨悪性腫瘍の治療2011

    • Author(s)
      吉崎智一
    • Organizer
      第21回日本耳科学会
    • Place of Presentation
      沖縄コンベンションセンター(宜野湾市)(パネリスト/招待講演)
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 頭頸部癌とアレルギー疾患の関連について2011

    • Author(s)
      吉崎智一
    • Organizer
      石川県耳鼻咽喉科医会学術集会
    • Place of Presentation
      ANAクラウンプラザホテル金沢(金沢市)(招待講演)
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Concurrent superselective intra-arterial chemoradiotherapy for advanced temporal bone squamous cell carcinoma2011

    • Author(s)
      Yoshizaki T, Sugimoto H, Ito M, Kondo S
    • Organizer
      the 28th Politzer Society Meeting
    • Place of Presentation
      The Westin Athens, Greece
    • Year and Date
      2011-09-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Treatment of Locally Recurrent Epstein-Barr Virus-associated Nasopharyngeal Carcinoma by Using the Anti-viral Agent Cidofovir2011

    • Author(s)
      Yoshizaki T, Kondo S, Sayaka Y
    • Organizer
      The 5th Interanational Symposium on Nasopharyngeal Carcinoma
    • Place of Presentation
      Shangri La Rasa Sayang Hotel, Malaysia
    • Year and Date
      2011-06-22
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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