| Project/Area Number |
23390396
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Hisashi 金沢大学, 附属病院, 講師 (20547179)
WAKISAKA Naohiro 金沢大学, 附属病院, 講師 (70377414)
KONDO Satoru 金沢大学, 附属病院, 助教 (70436822)
ENDO KAzuhira 金沢大学, 附属病院, 助教 (30547154)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | 上咽頭癌 / Epstein-Barr ウイルス / 内因性免疫 / 中咽頭癌 / ヒトパピローマウイルス / APOBEC / EBV / 内陰性免疫 |
|---|
| Outline of Final Research Achievements |
Intrinsic immunity, including APOBEC family, is a defense system inherent to a cell itself. Viral oncogenesis by EBV, HPV has been a matter of issue these days. We identified that APOBEC3G was overexpressed in both EBV-pisitive nasopharyngeal cancer and HPV-positive oropharyngeal cancer tissues. Moreover, APOBEC specific G to A, C to T mutations were frequently detected in HPV-E2 region. These results suggest that intrinsic immunity, especially, APOBEC3G, is associated with HPV-mediated oropharyngeal oncogenesis.
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