Prevent and therapeutic strategy bycombination of microarray and proteomics for seasonal allergic rhinitis caused by Japanese cedar pollen.
| Project/Area Number |
23390397
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Emiko 筑波大学, 医学(系)研究科(研究院), 准教授 (40344882)
SHAKASHITA Masafumi 福井大学, 医学部附属病院, 助教 (40555455)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Keywords | スギ花粉症 / アレルギー性鼻炎 / 網羅的解析 / 遺伝子多型 / ORMDL-3 / Intelectin-1 / Apolipoprotein A4 / C3a / GWAS / Allergin-1 / 肥満細胞 / 次世代シークエンサー / IgE / CST-1 / tight junction / 上皮 / パパイン / protease inhibitor / ORMDL3 / IL-17 / polyI:C / CD4陽性細胞 / リスクアレル / スフィンゴシン-1-リン酸 |
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| Research Abstract |
Sixty percent of adult in Japan have Japanese cedar pollen (JCP)-specific IgE. Prevalence of allergic rhinitis (AR) caused by JCP (AR-JCP) in Japanese adults is 40%. In this study we investigated AR-JCP-related gene by genome wide associated study, and gene expression by microarray and proteome analysis. We found that ORMDL-3, CST-1, IL-33, Allergin-1, and Apolipoprotein A4 are associated with onset of AR-JCP. Several SNP are also found to be associated with AR-JCP.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] A critical role of IL-33 in experimental allergic rhinitis2012
Author(s)
Haenuki Y, Matsushita K, Futatsugi-Yumikura S, Ishii KJ, Kawagoe T, Imoto Y, Fujieda S, Yasuda M, Hisa Y, Akira S, Nakanishi K, Yoshimoto T
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Journal Title
J Allergy Clin Immunol
Volume: (in press)
Issue: 1
Pages: 184-194
DOI
Related Report
Peer Reviewed
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[Journal Article] A randomized, double-blind, placebo-controlled study of ten-cha (Rubus suavissimus) on house dust mite allergic rhinitis2011
Author(s)
Yonekura S, Okamoto Y, Yamasaki K, Horiguchi S, Hanazawa T, Matsune S, Kurono Y, Yamada T, et al
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Journal Title
Auris Nasus Larynx
Volume: 38
Issue: 5
Pages: 600-607
DOI
Related Report
Peer Reviewed
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