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Investigation of the subretinal fibrosis due to vitreo-retinal diseases to develop new therapeutic strategies.

Research Project

Project/Area Number 23390402
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionYamaguchi University

Principal Investigator

SONODA Koh-Hei  山口大学, 医学(系)研究科(研究院), 教授 (10294943)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Hiroki  佐賀大学, 医学部, 教授 (40260715)
HARA Hiromitsu  佐賀大学, 医学部, 准教授 (20392079)
TAKEDA Atsunobu  九州大学, 大学院・医学系研究科, 助教 (40560313)
KOH Jie  広島大学, 大学院・医歯薬保健学研究院, 講師 (70314797)
KIMURA Kazuhiro  山口大学, 医学部附属病院, 講師 (60335255)
MORISHIGE Naoyuki  山口大学, 大学院・医学系研究科, 講師 (40346565)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords加齢黄斑変性 / 局所炎症 / 線維瘢痕化 / マクロファージ / 網膜色素上皮細胞 / 自然免疫 / IL-27
Research Abstract

We find that macrophages and RPE play an important role to form subretinal fibrosis. Subretinal macrophage inoculation leads to MCP-1 production from RPE. Due to cytokine/chemokine screening, we also find that IL-27 is markedly decreased in the inoculated site. Importantly, IL-27 supplementation prevents subretinal fibrosis. We thus propose that IL-27 supplementation and/or preventing IL-27 reduction must be effective to improve the visual acuity in the vitreoretinal disease patients.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (29 results)

All 2014 2013 2012 2011 Other

All Journal Article (16 results) (of which Peer Reviewed: 14 results) Presentation (9 results) (of which Invited: 2 results) Book (4 results)

  • [Journal Article] Regulation of Th1 and Th17 cell differentiation in uveitis2014

    • Author(s)
      Takeda A, Sonoda KH, Ishibashi T
    • Journal Title

      Inflammation and Regeneration

      Volume: (in press)

    • NAID

      130004482316

    • Related Report
      2013 Final Research Report
  • [Journal Article] Neuropeptides released from trigeminal neurons promote the stratification of human corneal epithelial cells2014

    • Author(s)
      Ko JA, Mizuno Y, Ohki C, Chikama T, Sonoda KH, Kiuchi Y
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 55 Pages: 125-133

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of Th1 and Th17 cell differentiation in uveitis.2014

    • Author(s)
      Takeda A, Sonoda KH, Ishibashi T
    • Journal Title

      Inflammation and Regeneration

      Volume: 印刷中

    • NAID

      130004482316

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Neuropeptides released from trigeminal neurons promote the stratification of human corneal epithelial cells.2014

    • Author(s)
      Ko JA, Mizuno Y, Ohki C, Chikama T, Sonoda KH, Kiuchi Y
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 55 Pages: 125-133

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-10 is significantly involved in HSP70-regulation of experimental subretinal fibrosis2013

    • Author(s)
      Yang Y, Takeda A, Yoshimura T, Oshima Y, Sonoda KH, Ishibashi T
    • Journal Title

      PLoS One

      Volume: 20

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Persistence of structural changes at the anterior cornea in bullous keratopathy patients after endothelial keratoplasty2013

    • Author(s)
      Morishige N, Yamada N, Morita Y, Kimura K, Sonoda KH
    • Journal Title

      PLoS One

      Volume: 8

    • NAID

      120005623384

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Novel Platelet-Activating Factor Receptor Antagonist Inhibits Choroidal Neovascularization and Subretinal Fibrosis2013

    • Author(s)
      Zhang H, Yang Y, Takeda A, Yoshimura T, Oshima Y, Sonoda KH, Ishibashi T
    • Journal Title

      PLoS One

      Volume: 8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase and cytokine expression in Tenon fibroblasts during scar formation after glaucoma filtration or implant surgery in rats2013

    • Author(s)
      Nakamura-Shibasaki M, Ko JA, Takenaka J, Chikama TI, Sonoda KH, Kiuchi Y
    • Journal Title

      Cell Biochem Funct

      Volume: 31 Pages: 482-488

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-10 is significantly involved in HSP70-regulation of experimental subretinal fibrosis.2013

    • Author(s)
      Yang Y, Takeda A, Yoshimura T, Oshima Y, Sonoda KH, Ishibashi T
    • Journal Title

      PLoS One

      Volume: 20

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Persistence of structural changes at the anterior cornea in bullous keratopathy patients after endothelial keratoplasty.2013

    • Author(s)
      Morishige N, Yamada N, Morita Y, Kimura K, Sonoda KH
    • Journal Title

      PLoS One

      Volume: 8

    • NAID

      120005623384

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Novel Platelet-Activating Factor Receptor Antagonist Inhibits Choroidal Neovascularization and Subretinal Fibrosis.2013

    • Author(s)
      Zhang H, Yang Y, Takeda A, Yoshimura T, Oshima Y, Sonoda KH, Ishibashi T
    • Journal Title

      PLoS One

      Volume: 8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase and cytokine expression in Tenon fibroblasts during scar formation after glaucoma filtration or implant surgery in rats.2013

    • Author(s)
      Nakamura-Shibasaki M, Ko JA, Takenaka J, Chikama TI, Sonoda KH, Kiuchi Y
    • Journal Title

      Cell Biochem Funct

      Volume: 31 Pages: 482-488

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn2012

    • Author(s)
      Hasegawa E, Oshima Y, Takeda A, Saeki K, Yoshida H, Sonoda KH, Ishibashi T
    • Journal Title

      J Leukoc Biol

      Volume: 91 Pages: 267-273

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of the preoperative duration of stromal edema in bullous keratopathy on early visual acuity after endothelial keratoplasty2012

    • Author(s)
      Morishige N, Chikama T, Yamada N, Takanashi N, Morita Y, Nishida T, Sonoda KH
    • Journal Title

      J Cataract Refract Surg

      Volume: 38 Pages: 303-308

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a new animal model of focal subretinal fibrosis that resembles disciform lesion in advanced age-related macular degeneration2011

    • Author(s)
      Jo YJ, Sonoda KH, Oshima Y, Takeda A, Kohno R, Yamada J, Hamuro J, Yang Y, Notomi S, Hisatomi T, Ishibashi T
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 52 Pages: 6089-6095

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of ICPO protein in tear fluid of individuals with active herpetic epithelial keratitis2011

    • Author(s)
      Morishige N, Yamada N, Morita Y, Nakamura Y, Nishida T, Sonoda KH
    • Journal Title

      Jpn J Ophthalmol

      Volume: 55 Pages: 591-594

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] The role of bone marrow-derived inflammatory cells in the formation of vitreoretinal disease2014

    • Author(s)
      Sonoda KH
    • Organizer
      UCL-Yamaguchi University special seminars in Opthalmology 150 Year Anniversary of UK-Japan Academic Interaction
    • Place of Presentation
      United Kingdom
    • Year and Date
      2014-03-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 合同シンポジウム2 講演「Human Immunology : 疾患理解から治療へ」ぶどう膜炎の病態と新規治療2013

    • Author(s)
      園田 康平
    • Organizer
      第25回日本神経免疫学会学術集会
    • Place of Presentation
      海峡メッセ下関(山口県)
    • Year and Date
      2013-11-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 生理/病理・「IL-27 と網膜疾患」2013

    • Author(s)
      園田 康平
    • Organizer
      第15回Japan Macula Club
    • Place of Presentation
      蒲郡クラシックホテル(愛知県)
    • Year and Date
      2013-08-18
    • Related Report
      2013 Final Research Report
  • [Presentation] The Development of Mutual Understandings and Collaborative Immunological Research Projects in APAO Nations2013

    • Author(s)
      Sonoda KH
    • Organizer
      The 28th Asia-Pacific Academy of Ophthalmology Congress
    • Place of Presentation
      INDIA
    • Year and Date
      2013-01-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Impact of preoperative duration of sromal edema in bullous keratopathy on early visual acuity after endothelial keratoplasty2012

    • Author(s)
      Morishige N, Yamada N, Morita Y, Sonoda KH
    • Organizer
      The 5th joint meeting of Japan-China-Korea Ophthalmologists
    • Place of Presentation
      Hotel Nikko Fukuoka, Japan
    • Year and Date
      2012-11-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of the JNK Signaling Pathway in Down-Regulation of Connexin43 by TNF- α in Human Corneal Fibroblasts2012

    • Author(s)
      Orita T, Kimura K, Sonoda KH
    • Organizer
      2012 ARVO Annual Meeting
    • Place of Presentation
      USA
    • Year and Date
      2012-05-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Management of Retinal Detachment Following ARN/CMV retinitis2012

    • Author(s)
      Sonoda KH
    • Organizer
      APAO/SOE 2012
    • Place of Presentation
      South Korea
    • Year and Date
      2012-04-15
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of bone marrow-derived inflammatory cells in the formation of vitreoretinal disease.

    • Author(s)
      Sonoda KH
    • Organizer
      UCL-Yamaguchi University special seminars in Opthalmology 150 Year Anniversary of UK-Japan Academic Interaction
    • Place of Presentation
      United Kingdom(London)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 合同シンポジウム2講演「Human Immunology:疾患理解から治療へ」ぶどう膜炎の病態と新規治療

    • Author(s)
      園田 康平
    • Organizer
      第25回日本神経免疫学会学術集会
    • Place of Presentation
      山口県(海峡メッセ下関)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Monthly Book OCULISTA2013

    • Author(s)
      園田 康平
    • Total Pages
      85
    • Publisher
      (株)全日本病院出版会
    • Related Report
      2013 Final Research Report
  • [Book] アレルギーの臨床2013

    • Author(s)
      園田 康平
    • Total Pages
      104
    • Publisher
      (株)北隆館
    • Related Report
      2013 Final Research Report
  • [Book] Monthly Book OCULISTA2013

    • Author(s)
      園田 康平
    • Total Pages
      85
    • Publisher
      (株)全日本病院出版会
    • Related Report
      2013 Annual Research Report
  • [Book] アレルギーの臨床2013

    • Author(s)
      園田 康平
    • Total Pages
      104
    • Publisher
      (株)北隆館
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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