| Project/Area Number |
23390402
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SONODA Koh-Hei 山口大学, 医学(系)研究科(研究院), 教授 (10294943)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Hiroki 佐賀大学, 医学部, 教授 (40260715)
HARA Hiromitsu 佐賀大学, 医学部, 准教授 (20392079)
TAKEDA Atsunobu 九州大学, 大学院・医学系研究科, 助教 (40560313)
KOH Jie 広島大学, 大学院・医歯薬保健学研究院, 講師 (70314797)
KIMURA Kazuhiro 山口大学, 医学部附属病院, 講師 (60335255)
MORISHIGE Naoyuki 山口大学, 大学院・医学系研究科, 講師 (40346565)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 加齢黄斑変性 / 局所炎症 / 線維瘢痕化 / マクロファージ / 網膜色素上皮細胞 / 自然免疫 / IL-27 |
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| Research Abstract |
We find that macrophages and RPE play an important role to form subretinal fibrosis. Subretinal macrophage inoculation leads to MCP-1 production from RPE. Due to cytokine/chemokine screening, we also find that IL-27 is markedly decreased in the inoculated site. Importantly, IL-27 supplementation prevents subretinal fibrosis. We thus propose that IL-27 supplementation and/or preventing IL-27 reduction must be effective to improve the visual acuity in the vitreoretinal disease patients.
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