| Project/Area Number |
23390403
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Toshihiro 熊本大学, 医学部附属病院, 講師 (00317025)
KAWAJI Takahiro 熊本大学, 医学部附属病院, 講師 (30423677)
稲谷 大 熊本大学, 医学部附属病院, 講師 (40335245)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 緑内障 / サイトカイン / 房水 / MCP-1 / 線維柱体 / シュレム管 |
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| Research Abstract |
The concentrations of IL-8, MCP-1, EGF and PDGF-AA were elevated in the glaucomatous aqueous humor. The history of cataract surgery affected the aqueous MCP-1 concentraiotn, which was the highest among the cytokines. MCP-1 treatment changed the intracellular localization of ZO-1, increased permeability of the monolayer of Schlemm's canal endothelial cells, and increased aqueous outflow. MCP-1 expressed in the rabbit iris and ciliary body, and phacoemulsification surgery increased its expression in the cornea, iris and ciliary body transiently, while the surgery induced time-dependent increase of its expression only in the lens capsule. We confirmed the MCP-1 expression in the lens epithelial cells after surgery. These results indicate that aqueous MCP-1 may be involved in the glaucoma pathology.
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