Establishment of new therapeutic protocol for pediatric renal tumor according to the new risk classification
| Project/Area Number |
23390405
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OUE Takaharu 大阪大学, 医学部, 講師 (50314315)
金子 安比古 埼玉県立がんセンター臨床腫瘍研究所, 研究所長 (50373387)
野崎 美和子 獨協医科大学越谷病院, 放射線科, 教授 (30197727)
大喜多 肇 国立成育医療研究センター研究所, 室長 (50317260)
樋之津 史郎 岡山大学病院, 新医療研究開発センター, 教授 (80323567)
上原 秀一郎 大阪大学, 医学(系)研究科(研究院), 助教 (00448060)
陳 基明 日本大学, 医学部, 准教授 (50277422)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 小児腎腫瘍 / 予後因子 / RASSF1A遺伝子 / WTX遺伝子 / 両側性腎芽腫 / 腎機能障害 / 治療プロトコール / 腎ラブドイド腫瘍 / 腎芽腫 / リスク分類 / 標準的治療 / 集学的治療 / RASSIA / メチル化 / 多施設共同研究 / Wilms腫瘍 |
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| Research Abstract |
We analyzed methylation status of tumor suppressor gene RASSF1A in 84 Wilms tumors and found out that it was significantly associated with a poor outcome. Moreover, we analyzed the mutation of WTX gene and revealed that this also was significantly associated with a poor outcome. Therefore these biomarkers were considered be candidates of the new biomarkers for risk classification to create the new therapeutic protocols.
The survival rate of bilateral Wilms tumors (BWT) has been improved; however, the results are not satisfactory in terms of the renal preservation. We reviewed the outcome of BWT registered in JWiTS. Bilateral nephron-sparing surgery (NSS) was achieved only in 10 of 28 cases (36%) and 10 children (40%) developed impaired renal function. The protocol should be changed to improve the rate of preservation of the renal parenchyma. Preoperative chemotherapy should be performed to shrink the tumors, and subsequent NSS should be carried out after a central imaging evaluation.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] Alterations of the genes involved in the P13K and estrogen-receptor pathways influence outcome in human epidermal growth factor receptor 2-positive and hormone receptor-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemotherapy2013
Author(s)
Kaneko Y, Takeda M, Higuchi T, Tozuka K, Takei H, Haruma M, Watanabe J, Kasai F, Inoue K, Kurosumi M, Miyazaki M, Sato-Otsubo A, Ogawa S
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Journal Title
BMC Cancer
Volume: 13
Pages: 241-241
Related Report
Peer Reviewed
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[Journal Article] RASSF1A methylation indicates a poor prognosis in hepatoblastoma patients2013
Author(s)
Honda S, Miyagi H, Suzuki H, Minato M, Haruta M, Kaneko Y, Hatanaka KC, Hiyama E, Kamijo T, Okada T, Taketomi A
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Journal Title
Pediatric Surgery International
Volume: 29
Issue: 11
Pages: 1147-1152
DOI
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Peer Reviewed / Open Access
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[Journal Article] Methylation of the RASSF1A promoter is predictive of poor outcome among patients with Wilms tumor2012
Author(s)
Ohshima J, Haruta M, Fujiwara W, Watanabe N, Arai Y, Ariga T, Okita H, Koshinaga T, Oue T, Hinotsu S, Nakadate H, Horie H, Fukuzawa M, Kaneko Y
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Journal Title
Pediatr Blood Cancer
Volume: 59
Issue: 3
Pages: 499-505
DOI
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Peer Reviewed
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[Presentation] Bilateral Wilms' tumors treated according to the Japan Wilms Tumor Study Group protocol2013
Author(s)
Oue T, Fukuzawa M, Okita H, HorieH, Saito M, Nozaki M, Chin M, Nakadate N, Hinotsu S, Koshinaga T, Kaneko Y, Tanaka Y
Organizer
45th Congress of the International Society of Paediatric Oncology
Place of Presentation
Hong Kong, China
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[Presentation] 日本ウィルムス腫瘍研究グループに登録された両側性腎芽腫の検討2013
Author(s)
大植孝治, 福澤正洋, 越永従道, 大喜多肇, 金子安比古, 堀江 弘, 斉藤正博, 野崎美和子, 陳 基明, 中館尚也, 樋之津史郎, 田中祐吉, 春田雅之, 桑島成子, 高安 肇
Organizer
第55回日本小児血液・がん学会
Place of Presentation
福岡
Related Report
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[Presentation] Bilateral Wilms’ tumors treated according to the Japan Wilms Tumor Study Group protocol2013
Author(s)
Oue T, Fukuzawa M, Okita H, HorieH, Saito M, Nozaki M, Chin M, Nakadate N, Hinotsu S, Koshinaga T, Kaneko Y, Tanaka Y
Organizer
45th Congress of the International Society of Paediatric Oncology
Place of Presentation
Hong Kong (中国)
Related Report
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[Presentation] Current Results the Japan Wilms Tumor Study (JWiTS) and Future Protocols2012
Author(s)
Oue T, Fukuzawa M, Okita H, Mugishima H, Horie H, Hata J, Saito M, Nozaki M, Chin M, Nakadate N, Hinotsu S, Koshinaga T, KanekoY, Kitano K, Tanaka Y
Organizer
第54回日本小児血液・がん学会学術集会
Place of Presentation
横浜
Related Report
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[Presentation] 日本におけるWT1 遺伝子変異を有するウィルムス腫瘍の臨床病理学的検討2011
Author(s)
大喜多肇, 秦順一, 柴田理恵, 高田礼子, 菊池春人, 藤本純一郎, 金子安比古, 堀江弘, 田中祐吉, 福澤正洋, 清河信敬
Organizer
第100回日本病理学会総会
Place of Presentation
パシフィコ横浜(神奈川県)
Related Report
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[Presentation] がん抑制遺伝子RASSF1A のプロモーターメチル化はWilms 腫瘍の予後不良因子である2011
Author(s)
大島淳二郎, 春田雅之, 渡辺直樹, 新井康仁, 寺下友佳代, 長祐子, 井口晶裕, 有賀正, 大喜多肇, 越永従道, 大植孝治, 樋之津史郎, 中舘尚也, 堀江弘, 福澤正洋, 金子安比古
Organizer
第53回日本小児血液・がん学会学術集会
Place of Presentation
ベイシア文化ホール(群馬県)
Related Report
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[Book] 系統小児外科学第3版(福澤正洋, 中村哲郎, 窪田昭男編), 病理組織検査法, 分子標的治療, 再生医療, 腎芽腫, 肝腫瘍, 横紋筋肉腫, 膵腫瘍, 悪性リンパ腫2013
Author(s)
大植孝治
Publisher
永井書店
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