| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Research Abstract |
The Keap1-Nrf2 system has been identified as an important for preventing cells from oxidative stress damage. In this study, we analyzed peroxiredoxin I(PrxI) which expression is regulated by Keap1-Nrf2 system. We used UVA irradiation as skin wound model, that causes cell apoptosis and inflammation. As a result, the cells derived from PrxI-knockout mice were significantly susceptible to UVA irradiation. It is revealed that PrxI is crucial factor to protect skin from oxidative stress, apoptosis and excess inflammatory response.
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