| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
Artificial dermis is an artificial material to play the dermis layer of the skin by transplantation on the full-thickness skin defect. However, the wound healing is prolonged in the intractable ulcer. Therefore we have developed a functional artificial dermis, which can be sustained release of cell growth factor (Collagen/Gelatin sponge: CGS).
We examined the effect of wound healing with dual sustained release of basic fibroblast growth factor (bFGF) and hepatocyte growth factor (HGF) bounded electrostatically to the CGS.
By the combination of bFGF and HGF with CGS, granulation tissue formation and epithelialization accelerated , further angiogenic effect has been observeed .
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