| Budget Amount *help |
¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
We recently established a cell culture prepared from lung tissue, which is resistant to trypsin treatment for 16 h. This cell maintained positivity for CD29 and CD 90, and osteogenesis could be induced by osteogenesis inducing media. Also, it abundantly expressed keratinocyte growth factor and released paracrine factors which induced surfactant protein expression in alveolar epithelial cells when it was co-cultured with alveolar epitheilal cells. We demonstrated therapeutic potential of this cell for the mouse lipopolysaccharide induced lung injury model, but further study is needed to establish efficacy of this cell as a clinical therapy option to ARDS.
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