Cell therapy for acute lung injury: possibility of lung derived mesenchymal stem cells
| Project/Area Number |
23390411
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
UCHIDA Tokujiro 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (40262183)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 間葉系幹細胞 / 急性肺傷害 / ARDS / 細胞治療 / 体性幹細胞 / トリプシン / 肺胞上皮細胞 |
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| Outline of Final Research Achievements |
We recently established a cell culture prepared from lung tissue, which is resistant to trypsin treatment for 16 h. This cell maintained positivity for CD29 and CD 90, and osteogenesis could be induced by osteogenesis inducing media. Also, it abundantly expressed keratinocyte growth factor and released paracrine factors which induced surfactant protein expression in alveolar epithelial cells when it was co-cultured with alveolar epitheilal cells. We demonstrated therapeutic potential of this cell for the mouse lipopolysaccharide induced lung injury model, but further study is needed to establish efficacy of this cell as a clinical therapy option to ARDS.
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Report
(5 results)
Research Products
(11 results)
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[Journal Article] Effects of atrial natriuretic peptide on inter-organ crosstalk among the kidney, lung, and heart in a rat model of renal ischemia-reperfusion injury2014
Author(s)
Mitaka C, Hnin Si MK, Tulafu M, Qi Y, Uchida T, Abe S, Kitagawa M, Ikeda S, Eishi Y, Tomita M
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Journal Title
Intensive Care Medicine Experimental
Volume: 2
Issue: 1
Pages: 28-44
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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