| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
In severe sepsis patients, the ratio of CD14・CD16-double positive activated monocytes to CD14-positive monocytes measured by a flow-cytometer correlated to the severity of sepsis: increase at an early phase and decrease with a recovery of the illness to the normal levels of the ratio. On the other hand, activated monocytes decreased in severe trauma and burn patients, especially CD14-positive monocyte almost disappeared in the peripheral blood of the most severe case, indicating that the biological responses were suppressed to the excessive severity of injuries.
Phospho-proteome analysis showed that a DAMPs-related protein was phosphorylated in monocytes obtained from the severe sepsis patients. This phosphorylation of the intracellular protein may be an early physiological response to sepsis.
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