Establishment of a new strategy for the treatment of spinal cord injury: Intrathecal administration of incubated autologous bone marrow stromal cells.
| Project/Area Number |
23390414
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Yoshihisa 田附興風会, 第6研究部, 研究主幹 (30243025)
IDE Chizuka 藍野大学, 保健医療学部, 教授 (70010080)
FUKUSHIMA Masanori 先端医療振興財団, 臨床研究情報センター, センター長 (80107820)
IWASE Masaaki 関西医科大学, 医学部, 准教授 (30247902)
SAITO Fukuki 関西医科大学, 医学部, 講師 (01046227)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Keywords | 脊髄損傷 / 脊髄再生 / 骨髄単核球 / 髄液内投与 / 骨髄間質細胞 / 四肢麻痺 / 対麻痺 / 運動スコア / 知覚スコア / AIS grade / 単核球 / 幹細胞 |
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| Research Abstract |
To determine whether intrathecal administration of autologous bone marrow cells is safe and feasible for treatment of subacute spinal injury, five patients with tetraplegia due to cervical spinal injury and 5 with paraplegia due to thoracic spinal injury were included. About 1 million mononuclear cells were obtained from their own iliac bone, and administered immediately into cerebrospinal fluid by lumbar puncture. The patients were closely observed for 6 months. No adverse responses were observed. In a few patients treated earlier, definite motor and sensory recovery was remarkable, but limited in patients treated later. Spinal injury treatment with administration of bone marrow cells into cerebrospinal fluid is safe and feasible underwent in the early subacute phase.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Effects of bone marrow stromal cell transplantation through CSF on the subacute and chronic spinal cord injury in rats2013
Author(s)
Nakano N, Nakai Y, Seo TB, Homma T, Yamada Y, Ohta M, Suzuki Y, Nakatani T, Fukushima M, Hayashibe M, Ide C
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Journal Title
PloS ONE
Volume: 8(9)
Issue: 9
Pages: e73494-e73494
DOI
Related Report
Peer Reviewed
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[Presentation] Clinical trials for spinal injury treatmment with autologous bone marrow cells administration into cerebrospnal fluid2013
Author(s)
Toshio Nakatani, Yoshimasa Suzuki, Fukuki Saito, Masaaki Iwase, Yuji Maeda, Masanobu Tsuda, Yasuyuki Kuwagata, Masanori Fukushima, Chizuka Ide
Organizer
7th Asian Conference on Emergency Medicine (ACEM2013)
Place of Presentation
Tokyo International Forum, Tokyo, Japan
Related Report
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[Presentation] 当院における脊髄損傷に対する再生医療への取り組み2012
Author(s)
齊藤福樹, 岩瀬正顕, 中谷壽男, 津田雅庸, 前田裕仁, 宮崎秀行, 北元 健, 金沢武哲, 鈴木義久, 井出千束, 福島雅典
Organizer
第40回日本救急医学会総会
Place of Presentation
京都・国立京都国際会館
Year and Date
2012-11-15
Related Report
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[Presentation] 頸髄外傷の現状と問題点2012
Author(s)
岩瀬正顕, 中谷壽男, 淺井昭雄
Organizer
第26回日本外傷学会
Place of Presentation
リーガロイヤルホテル東京, 東京
Year and Date
2012-05-25
Related Report
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