| Project/Area Number |
23390414
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Kansai Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Yoshihisa 田附興風会, 第6研究部, 研究主幹 (30243025)
IDE Chizuka 藍野大学, 保健医療学部, 教授 (70010080)
FUKUSHIMA Masanori 先端医療振興財団, 臨床研究情報センター, センター長 (80107820)
IWASE Masaaki 関西医科大学, 医学部, 准教授 (30247902)
SAITO Fukuki 関西医科大学, 医学部, 講師 (01046227)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
|
|---|
| Keywords | 脊髄損傷 / 脊髄再生 / 骨髄単核球 / 髄液内投与 / 骨髄間質細胞 / 四肢麻痺 / 対麻痺 / 運動スコア / 知覚スコア / AIS grade / 単核球 / 幹細胞 |
|---|
| Research Abstract |
To determine whether intrathecal administration of autologous bone marrow cells is safe and feasible for treatment of subacute spinal injury, five patients with tetraplegia due to cervical spinal injury and 5 with paraplegia due to thoracic spinal injury were included. About 1 million mononuclear cells were obtained from their own iliac bone, and administered immediately into cerebrospinal fluid by lumbar puncture. The patients were closely observed for 6 months. No adverse responses were observed. In a few patients treated earlier, definite motor and sensory recovery was remarkable, but limited in patients treated later. Spinal injury treatment with administration of bone marrow cells into cerebrospinal fluid is safe and feasible underwent in the early subacute phase.
|
