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A Development of automated medical drug delivery system to support management of circulation, coupled with a neural treatment

Research Project

Project/Area Number 23390415
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

KAMIYA ATSUNORI  独立行政法人国立循環器病研究センター, 研究所, 研究員 (30324370)

Co-Investigator(Kenkyū-buntansha) SUGIMACHI Masaru  独立行政法人国立循環器病研究センター研究所, 部長 (40250261)
KAWADA Toru  独立行政法人国立循環器病研究センター研究所, 室長 (30243752)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords集中治療医学 / 自動医療 / 循環 / 心不全 / 自動治療 / 生体医工学 / 生体システム / 左心房圧 / 肺動脈圧 / 右心房圧 / 医工学
Research Abstract

Management of circulation in intensive care medicine is a highly specialized medical treatment, that directly determines vital prognosis of patients. Recently, however, a lack of physician decreases a medical care, while a great physical stress of physician leads human errors, as widely recognized as a social problem. The present study is a challenge to resolve the problem by creating automated medical system based on physiology, biomedical engineering and technology. It developed the automated medical system, in which a computer makes a diagnosis about cardiovascular dynamics, delivers multiple drugs simultaneously and improved cardiovascular dynamics, with emphasizing on a prediction of left atrial pressure, a fail-safe device, an alerm and an neural treatment.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (43 results)

All 2013 2012 2011 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (30 results)

  • [Journal Article] Sympathetic Afferent Stimulation Inhibits Central Vagal Activation Induced by Intravenous Medetomidine in Rats2013

    • Author(s)
      Kawada T, Akiyama T, Shimizu S, Kamiya A, Uemura K, Turner Michael J, Shirai M, Sugimachi M
    • Journal Title

      Acta Physiol (Oxf)

      Volume: 10 Issue: 1 Pages: 100-110

    • DOI

      10.1111/apha.12123

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of cilnidipine on sympathetic outflow and sympathetic arterial pressure and heart rate regulations in rats2013

    • Author(s)
      Yamamoto H, Kawada T, Shimizu S, Kamiya A, Miyazaki S, Sugimachi M
    • Journal Title

      Life Sci

      Volume: 92(24-26) Issue: 24-26 Pages: 1202-7

    • DOI

      10.1016/j.lfs.2013.05.004

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-frequency dominant depression of peripheral vagal control of heart rate in rats with chronic heart failure2013

    • Author(s)
      Kawada T, Li M, Shimizu S, Kamiya A, Uemura K, Turner MJ, Mizuno M, Sugimachi M
    • Journal Title

      Acta Physiologica (Oxford)

      Volume: 207 Issue: 3 Pages: 494-502

    • DOI

      10.1111/apha.12055

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central Vagal Activation by Alpha2-Adrenergic Stimulation is Impaired in Spontaneously Hypertensive Rats2012

    • Author(s)
      Kawada T, Akiyama T, Shimizu S, Kamiya A, Uemura K, Sata Y, Shirai M, Sugimachi M
    • Journal Title

      Acta Physiol (Oxf)

      Volume: 206(1) Pages: 72-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adaptation of the respiratory controller contributes to the attenuation of exercise hyperpnea in endurance-trained athletes2012

    • Author(s)
      Miyamoto T, Inagaki M, Takaki H, Kawada T, Shishido T, Kamiya A, Sugimachi M
    • Journal Title

      Eur J Appl Physiol

      Volume: 112(1) Pages: 237-51

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Medetomidine, an α2-adrenergic agonist, activates cardiac vagal nerve through modulating baroreflex control2012

    • Author(s)
      Shimizu S, Akiyama T, Kawada T, Sata Y, Mizuno M, Kamiya A, Shishido T, Inagaki M, Shirai M, Sano S, Sugimachi M
    • Journal Title

      Circ J

      Volume: 76(1) Pages: 152-9

    • NAID

      10030034497

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Medetomidine, an α2-adrenergic agonist, activates cardiac vagal nerve through modulating baroreflex control.2012

    • Author(s)
      Shimizu S, Akiyama T, Kawada T, Sata Y, Mizuno M, Kamiya A, Shishido T, Inagaki M, Shirai M, Sano S, Sugimachi M.
    • Journal Title

      Circ J

      Volume: 76(1) Pages: 152-9

    • NAID

      10030034497

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central vagal activation by alpha2-adrenergic stimulation is impaired in spontaneously hypertensive rats2012

    • Author(s)
      Kawada T, Akiyama T, Shimizu S, Kamiya A, Uemura K, et al
    • Journal Title

      Acta Physiol (Oxf)

      Volume: (in press) Issue: 1 Pages: 72-79

    • DOI

      10.1111/j.1748-1716.2012.02439.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contrasting effects of moderate vagal stimulation on heart rate and carotid sinus baroreflex-mediated sympathetic arterial pressure regulation in rats2011

    • Author(s)
      Kawada T, Shimizu S, Li M, Kamiya A, Uemura K, Sata Y, Yamamoto H, Sugimachi M
    • Journal Title

      Life Sci

      Volume: 89(13-14) Pages: 498-503

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Norwood procedure with non-valved right ventricle to pulmonary artery shunt improves ventricular energetics despite the presence of diastolic regurgitation : a theoretical analysis2011

    • Author(s)
      Shimizu S, Une D, Shishido T, Kamiya A, Kawada T, Sano S, Sugimachi M
    • Journal Title

      J Physiol Sci

      Volume: 61(6) Pages: 457-65

    • NAID

      10030350907

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Centrally administered ghrelin activates cardiac vagal nerve in anesthetized rabbits2011

    • Author(s)
      Shimizu S, Akiyama T, Kawada T, Sonobe T, Kamiya A, Shishido T, Tokudome T, Hosoda H, Shirai M, Kangawa K, Sugimachi M
    • Journal Title

      Auton Neurosci

      Volume: 162(1-2) Pages: 60-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Consideration on step duration to assess open-loop static characteristics of the carotid sinus baroreflex in rats2011

    • Author(s)
      Kawada T, Shimizu S, Sata Y, Kamiya A, Sunagawa K, Sugimachi M
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc

      Volume: 1 Pages: 689-92

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Closed-loop spontaneous baroreflex transfer function is inappropriate for system identification of neural arc but partly accurate for peripheral arc : predictability analysis2011

    • Author(s)
      Kamiya A, Kawada T, Shimizu S, Sugimachi M
    • Journal Title

      J Physiol

      Volume: 589(Pt 7) Pages: 1769-90

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 迷走神経刺激治療は心不全ラットの動脈圧受容器反射の中枢機能を改善する2013

    • Author(s)
      川田 徹、李 梅花、鄭 燦、清水 秀二、ターナー マイケル、神谷 厚範、上村 和紀、杉町 勝
    • Organizer
      日本循環制御医学会総会
    • Place of Presentation
      福井
    • Related Report
      2013 Annual Research Report
  • [Presentation] Component Model of Congenital Heart Disease2013

    • Author(s)
      Shimizu S, KawadaT, KamiyaA, Sugimachi M
    • Organizer
      35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
  • [Presentation] Medetomidine can selectively activate cardiac vagal nerve without vagal activation in gastrointestinal tract.2013

    • Author(s)
      S.Shimizu,T.Kawada,Y,Sata,A,Kamiya,M.Sugimachi
    • Organizer
      ESC CONGRESS 2013
    • Place of Presentation
      Amsterdam
    • Related Report
      2013 Annual Research Report
  • [Presentation] Biventricular repair with atrial fenestration adds little advantage to the postoperative haemodynamics in borderline candidates compared to the one and a half ventricle repair.2013

    • Author(s)
      4. S.Shimizu,T.Kawada,A.Kamiya,M.Sugimachi
    • Organizer
      ESC CONGRESS 2013
    • Place of Presentation
      Amsterdam
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of Chronic Vagal Stimulation on Open-loop Baroreflex Function in Heart Failure Rats2013

    • Author(s)
      Toru Kawada,Meihua Li,Can Zheng,Shuji Shimizu,Atsunori Kamiya,Michael James Turner,Masaru Sugimachi
    • Organizer
      American Heart Association
    • Place of Presentation
      Dalas
    • Related Report
      2013 Annual Research Report
  • [Presentation] メデトミジンは心臓迷走神経活動を賦活化し2012

    • Author(s)
      清水 秀二, 川田 徹, 秋山 剛, 神谷 厚範, 杉町 勝
    • Organizer
      胃迷走神経活動を抑制する第105回近畿生理学談話会
    • Place of Presentation
      関西医科大学
    • Year and Date
      2012-09-29
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットにおける迷走神経による動的心拍数調節の伝達関数モデルの改良2012

    • Author(s)
      川田 徹, 鄭 燦, ターナー マイケル, 清水 秀二, 神谷 厚範, 杉町 勝
    • Organizer
      第51回日本生体医工学会大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] ラットにおける迷走神経による動的心拍数調節の新しいモデル化2012

    • Author(s)
      川田 徹, 李 梅花, 鄭 燦, 清水 秀二, 神谷 厚範, 杉町 勝
    • Organizer
      第33回日本循環制御医学会総会
    • Place of Presentation
      自治医科大学 地域医療情報研修センター
    • Related Report
      2013 Final Research Report
  • [Presentation] Consideration on Parameter Determination of a New Model Describing Dynamic Vagal Hert Rate Control in Rats2012

    • Author(s)
      Kawada T, Shimizu S, Kamiya A, Turner MJ, Mizuno M, Sugimachi M, Sunagawa K
    • Organizer
      34TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BILOLPGY SOCIETY
    • Place of Presentation
      Hilton San Diego Bayfront
    • Related Report
      2013 Final Research Report
  • [Presentation] Lognormal Distribution of Sympathetic Nerve Activity in Normotensive and Spontaneously Hypertensive Rats2012

    • Author(s)
      Kawada T, Shimizu S, Kamiya A, Sugimachi M
    • Organizer
      AHA Scientific Sessions 2012
    • Place of Presentation
      Los Angeles Convention Center
    • Related Report
      2013 Final Research Report
  • [Presentation] インテリジェント自動医療の開発 : 心不全循環管理と自律神経医療2012

    • Author(s)
      神谷 厚範
    • Organizer
      日本機械学会第24回バイオエンジニアリング講演会
    • Place of Presentation
      大阪大学豊中キャンパス
    • Related Report
      2013 Final Research Report
  • [Presentation] 迷走神経切断が正常および心筋梗塞が心不全ラットの動脈圧反射動特性に及ぼす影響2012

    • Author(s)
      川田 徹, 清水 秀二, 神谷 厚範, 杉町 勝
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館・松本市総合体育館・信州大学松本キャンパス
    • Related Report
      2013 Final Research Report
  • [Presentation] 左心低形成症候群に対する両側肺動脈絞扼術後の血行動態シュミレーション2012

    • Author(s)
      清水 秀二, 川田 徹, 神谷 厚範, 杉町 勝
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館・松本市総合体育館・信州大学松本キャンパス
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットにおける迷走神経による動的心拍数調節の新しいモデル化2012

    • Author(s)
      2. 川田 徹、李 梅花、鄭 燦、清水 秀二、上村 和紀、神谷 厚範、杉町 勝
    • Organizer
      第33回日本循環制御医学会総会
    • Place of Presentation
      自治医科大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Lognormal Distribution of Sympathetic Nerve Activity in Normotensive and Spontaneously Hypertensive Rats.2012

    • Author(s)
      5. Toru Kawada, Shuji Shimizu, Atsunori Kamiya, Kazunori Uemura, Meihua Li, Can Zheng, Masaru Sugimachi
    • Organizer
      AHA Scientific Sessions 2012
    • Place of Presentation
      Los Angeles Convention Center
    • Related Report
      2012 Annual Research Report
  • [Presentation] System identification of closed-loop biosystem, predictability and problems in baroreflex2011

    • Author(s)
      Atsunori Kamiya, Toru Kawada, Masaru Sugimachi
    • Organizer
      日本生体医工学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 閉ループ生体システムの同定, 予測と問題点 : 圧反射を対象に2011

    • Author(s)
      神谷 厚範, 川田 徹, 杉町 勝
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京電機大学神田キャンパス
    • Related Report
      2013 Final Research Report
  • [Presentation] アンジオテンシンIIの静脈内投与がラットの動脈圧受容器反射の動特性に及ぼす影響2011

    • Author(s)
      川田 徹, 宍戸 稔聡, 神谷 厚範, 上村 和紀, 日高 一郎, 高木 洋, 杉町 勝
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京電機大学神田キャンパス
    • Related Report
      2013 Final Research Report
  • [Presentation] 迷走神経切除が動脈圧受容器反射の動特性に及ぼす影響2011

    • Author(s)
      川田 徹, 清水 秀二, 佐田 悠輔, 李 梅花, 神谷 厚範, 宍戸 稔聡, 杉町 勝
    • Organizer
      第32回日本循環制御医学会総会
    • Place of Presentation
      富山国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] 上大静脈・肺動脈吻合が, 左心補助循環中の血行動態に与える影響2011

    • Author(s)
      清水 秀二, 宍戸 稔聡, 川田 徹, 佐田 悠輔, 神谷 厚範, 杉町 勝
    • Organizer
      第32回日本循環制御医学会総会
    • Place of Presentation
      富山国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] Alpha-2 adrenergic agonists enhances baroreflex-induced cardiac vagal acetylcholine release2011

    • Author(s)
      Shuji Shimizu, Tsuyoshi Akiyama, Toru Kawada, Yusuke Sata, Atsunori Kamiya, Mikiyasu Shirai, Masaru Sugimachi
    • Organizer
      第75回日本循環器学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Consideration on Step Duration to Assess Open-Loop Static Characteristics of the Carotid Sinus Baroreflex in Rats2011

    • Author(s)
      Kawada T, Sata Y, Shimizu S, Kamiya A, Sunagawa K, Sugimachi M
    • Organizer
      33RD Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Boston Marriott Copley Place
    • Related Report
      2013 Final Research Report
  • [Presentation] Cavopulmonary shunt after LVAD implantation improves haemodynamics in patients heaving relatively impaired right heart : an in-silico analysis2011

    • Author(s)
      Shimizu S, Shishido T, Kawada T, Sata Y, Kamiya A, Sugimachi M
    • Organizer
      ESC Congress 2011
    • Place of Presentation
      Paris Nord Villepinte
    • Related Report
      2013 Final Research Report
  • [Presentation] 迷走神経刺激治療は心不全ラットの動脈圧受容器反射の中枢機能を改善する

    • Author(s)
      川田 徹, 李 梅花, 鄭 燦, 清水 秀二, ターナー マイケル, 神谷 厚範, 上村 和紀, 杉町 勝
    • Organizer
      第34回日本循環制御医学会総会
    • Related Report
      2013 Final Research Report
  • [Presentation] Minimal Component Model of Congenital Heart Disease

    • Author(s)
      Shuji S, Kawada T, Kamiya A, Sugimachi M
    • Organizer
      35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2013 Final Research Report
  • [Presentation] Medetomidine can selectively activate cardiac vagal nerve without vagal activation in gastrointestinal tract

    • Author(s)
      S. Shimizu, T.Kawada, Y, Sata, A, Kamiya, M. Sugimachi
    • Organizer
      ESC CONGRESS 2013
    • Related Report
      2013 Final Research Report
  • [Presentation] Biventricular repair with atrial fenestration adds little advantage to the postoperative haemodynamics in borderline candidates compared to the one and a half ventricle repair

    • Author(s)
      Shimizu S, Kawada T, Kamiya A, Sugimachi M
    • Organizer
      ESC CONGRESS 2013
    • Related Report
      2013 Final Research Report
  • [Presentation] マイクロダイアリシス法による腎内因性アセチルコリン分泌機構の解明

    • Author(s)
      清水 秀二, 川田 徹, マイケル・ジェームス・ターナー, 神谷 厚範, 杉町 勝
    • Organizer
      第106回近畿生理学談話会
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of Chronic Vagal Stimulation on Open-loop Baroreflex Function in Heart Failure Rats

    • Author(s)
      Kawada T, Li M, Zheng C, Shuji S, Kamiya A, Turner MJ, Sugimachi M
    • Organizer
      American Heart Association
    • Related Report
      2013 Final Research Report
  • [Presentation] メデトミジンは心臓迷走神経活動を賦活化し、胃迷走神経活動を抑制する

    • Author(s)
      清水 秀二、川田 徹、秋山 剛、神谷 厚範、杉町 勝
    • Organizer
      第105回近畿生理学談話会
    • Place of Presentation
      関西医科大学
    • Related Report
      2012 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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