| Project/Area Number |
23390420
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
TSUKINOKI Keiichi 神奈川歯科大学, 歯学研究科(研究院), 教授 (00298233)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Ichiro 鶴見大学, 歯学部, 教授 (60147634)
SUGIMOTO Masahiro 京都大学, 大学院・医学研究科, 講師 (30458963)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Keywords | BDNF / 唾液腺 / 咀嚼運動 / うつ病 / 抗鬱効果 / ATP / 唾液 / 抗うつ薬 / ATP受容体 |
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| Research Abstract |
In this study, we examined whether there are association between antidepressant and BDNF increased by chewing. The BDNF strong expression mouse derived from salivary gland showed a high BDNF blood symptom by ELISA system. Using this Tg mouse, we examined an action physiologic change by open field test and an elevated cross maze. The center invasion number of times, sojourn time in open field test was significantly high in the open arm invasion number of times with Tg mouse in the elevated cross maze. It was suggested that salivary gland BDNF showed an antianxiety effect in the central nervous system. In summary, by the animal experiment, the salivary gland BDNF may be antidepressant effect, but it will be necessary to examine it in detail in future whether BDNF increased by human chewing has antidepressant effects.
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