| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Research Abstract |
Calorie restriction (CR) showed increase of Sirt1 expression and activity in mice salivary glands. The increased saliva secretion and the decreased 8 OH-dG, an oxidative stress marker, were confirmed. The infiltration of inflammatory cells and inflammatory cytokines were diminished. From the microarray analysis, inflammatory and immune related genes were decreased and amino acid related genes were increased. Moreover, serine revealed increased tendency saliva secretion. The number of mitochondria and the mutated mitochondria genes were decreased. However, ATP production was increased.
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