Analysis of salivary secretory function via Sirt1 activation
| Project/Area Number |
23390421
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
SAITO Ichiro 鶴見大学, 歯学部, 教授 (60147634)
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| Co-Investigator(Kenkyū-buntansha) |
MISHIMA Kenji 昭和大学, 歯学部, 教授 (50275343)
INOUE Hiroko 日本薬科大学, 薬学部, 准教授 (50367306)
RYO Koufuchi 鶴見大学, 歯学部, 講師 (10298268)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 唾液腺 / Sirt1 / カロリー制限 / 唾液分泌 / Sirt1遺伝子 / 唾液腺分泌 / ドライマウス |
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| Research Abstract |
Calorie restriction (CR) showed increase of Sirt1 expression and activity in mice salivary glands. The increased saliva secretion and the decreased 8 OH-dG, an oxidative stress marker, were confirmed. The infiltration of inflammatory cells and inflammatory cytokines were diminished. From the microarray analysis, inflammatory and immune related genes were decreased and amino acid related genes were increased. Moreover, serine revealed increased tendency saliva secretion. The number of mitochondria and the mutated mitochondria genes were decreased. However, ATP production was increased.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Transplantation of side population cells restores the function of damaged exocrine glands through clusterin2012
Author(s)
Mishima K., Inoue H., Nishiyama T., Mabuchi Y., Amano Y., Ide F., Matsui M., Yamada H., Yamamoto G., Tanaka J., Yasuhara R., Sakurai T., Lee M., Chiba K., Sumimoto H., Kawakami Y., Matsuzaki Y., Tsubota K., Saito I
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Journal Title
Stem Cells
Volume: 30
Issue: 9
Pages: 1925-37
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of coenzyme Q10 on salivary secretion 669-674 (2011)2011
Author(s)
Ryo K, Ito A, Takatori R, Tai Y, Arikawa K, Seido T, Yamada T, Shinpo K, Tamaki Y, Fujii K, Yamamoto Y, Saito I
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Journal Title
Clin Biochem
Volume: 44
Issue: 8-9
Pages: 669-674
DOI
Related Report
Peer Reviewed
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