| Project/Area Number |
23390428
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Okayama University |
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Principal Investigator |
KOKEGUCHI Susumu 岡山大学, 医歯(薬)学総合研究科, 准教授 (10144776)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Hiroshi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (00274001)
MURAKAMI Jun 岡山大学, 大学病院, 助教 (40362983)
KARIYAMA Reiko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40112148)
YOKOTA Kenji 岡山大学, 大学院・保健学研究科, 准教授 (00243460)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIMURA Fusanori 広島大学, 医歯薬学総合研究科, 教授 (80208222)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Keywords | 感染症 / 歯周病細菌 / HACEK群細菌 / 心臓・血管疾患 / A. actinomycetemcomitans / 口腔細菌 / Aggregatibacter actinomycetemcomitans |
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| Research Abstract |
Several microbiologic and epidemiologic studies have suggested an association between oral bacteria and systemic health such as diabetes, respiratory diseases and cardiovascular diseases. The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) among oral bacteria are noted as the pathogens of infective endocarditis. The aim of this study is to determine the possible pathogenic factors of Aggregatibacter actinomycetemcomitans and oral methanogenic Archaea on infective endocarditis, and to analyze clinical and microbiological characteristics of the patients with infective endocarditis. Cell surface enolase and RNA chaperone protein, Hfq in A. actinomycetemcomitans and group II chaperonin of oral methanogenic Archaea were further characterized. The antimicrobial activity of inhibitor for methionine aminopeptidase and vitamin K analogues were also examined as a candidate of new therapeutic agents.
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