Regulatory effect of the TLR/TACI-MyD88 signaling pathway on immune responses associated with the homing of IgA-producing B cells into salivary glands
| Project/Area Number |
23390431
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Asahi University |
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Principal Investigator |
INTO Takeshi 朝日大学, 歯学部, 講師 (10360918)
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| Co-Investigator(Kenkyū-buntansha) |
TAKIGAWA Toshiya 朝日大学, 歯学部, 教授 (90263095)
TAKAYAMA Eiji 朝日大学, 歯学部, 准教授 (70533446)
INOMATA Megumi 朝日大学, 歯学部, 助教 (40553798)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIBATA Ken-ichiro 北海道大学, 大学院・歯学研究科, 教授 (50145265)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 自然免疫 / 唾液腺 / シェーグレン症候群 / 自己免疫 / IgA / Ｂ細胞 / ＩｇＡ / ＭｙＤ８８ / Toll様受容体 / ＴＡＣＩ / 粘膜免疫 / B細胞 / MyD88 / TACI |
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| Research Abstract |
The aim of this basic research project is to clarify the effect of cellular signaling molecule MyD88-mediated immune responses on the homing of IgA-producing B cells into salivary glands, the mechanism of which underlies basic oral immune defense machineries. Through our execution of the experimental plans, it had been figured out that MyD88 deficiency hardly affected IgA production in mouse salivary glands. However, we have found that mouse MyD88 deficiency remarkably suppresses the lymphoid-associated pathogenesis found in female mice, which resembles the pathogenesis of Sjogren's syndrome in humans. Thus, although this study project had not attained our original aim, we have been able to obtain a certain degree of results that are adequate for a basic research project. For our future investigations, we are planning to make efficient use of the results obtained through this project.
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Report
(4 results)
Research Products
(23 results)
