| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Research Abstract |
This study was designed with the ultimate purpose of establishing a tooth pulp tissue engineering using transplantation of dental pulp stem cells, and conducted to select appropriate scaffolds and develop an experimental engineering system using rat molars. It was demonstrated that rat dental pulp is equipped with stem-like cells that coexpress CD146 and MAP1B and are distributed predominantly in theperivascular area. rat dental pulp by means of immunohistochemistry. Moreover, transplantation of rat mesenchymal stem cells into pulpotomized rat molars with a PLLA/Puramatrix scaffold resulted in the formation of new mineralized tissues at 4 weeks. These results suggest that the experimental model used in this study is useful for investigating the pulp tissue regeneratiopn using stem cell transplantation.
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