| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Research Abstract |
Aiming at achievement of adhesive resins with the function to promote tissue regeneration, novel hydrogel as a carrier of protein was fabricated by copolymerization of HEMA and a cross-linking monomer. The experimental poly-HEMA-based hydrogel particle was effective for loading and long-term release of proteins. The analysis of release kinetics and in vitro cell culture studies demonstrated that FGF-2-releasing particle was successfully developed by loading FGF-2 to the experimental poly-HEMA-based hydrogel particle. In addition, 4-META/MMA-based adhesive resins were found to be possibly combined with theFGF-2-releasing hydrogel particle, and the benefits of combination of these two components were suggested.
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