Development of a new comprehensive treatment for dental caries based on minimum intervention dentistry
| Project/Area Number |
23390435
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MATSUO Takashi 徳島大学, ヘルスバイオサイエンス研究部, 教授 (30173800)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Tadashi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (00217770)
SUGE Toshiyuki 徳島大学, 病院, 講師 (60243713)
YUMOTO Hiromichi 徳島大学, 病院, 講師 (60284303)
HIRAO Kouji 徳島大学, 病院, 助教 (00581399)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 齲蝕 / 歯髄炎 / ミニマムインターベンション / 高周波/電磁波 / アンモニウムヘクサフルオロシリケート / 齲蝕治療法 / ミニマルインターベンション / 象牙質再石灰化法 / 電磁波/高周波 / 自然免疫応答 / ミニマルインターベンション（MI） / フッ化ジアミンシリケート / ポリフェノール |
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| Research Abstract |
In Japan, challenging cases of dental disease such as root surface caries become a problem in step with a rapid aging society. We tried to develop a new comprehensive treatment of caries based on minimum intervention. First, we developed the remineralization and reinforcement of decalcified tooth using ammonium hexafluorosilicate (SiF) with antimicrobial agents. Second, we developed the disinfection of caries related bacteria with electro-magnetic wave irradiation (EMWI). And finally, we examined the anti-inflammatory effects of tea catechin to fibroblasts to develop a new treatment for deep carious lesion.
We found the increase of crystallinity of hydroxyapatite with SiF treatment and antibacterial agents such as catechin are effective with SiF. Also, we found the bacteriocidal or inactive effects of EMWI on S. mutans. Catechin had inhibited the production of cytokines and chemokines from pulpal fibroblasts.
These results indicate the possibility of new caries treatment.
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Report
(4 results)
Research Products
(74 results)
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[Journal Article] 歯髄疾患の病態と診断2013
Author(s)
松尾敬志, 尾崎和美, 中西 正, 湯本浩通, 高橋加奈子, 平尾功治, 武川大輔
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Journal Title
日歯内療誌
Volume: 34
Pages: 67-76
NAID
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Peer Reviewed
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[Presentation] Streptococcus mutansの病原性におけるscrA遺伝子の役割.
Author(s)
木村智子, 尾崎和美, 湯本浩通, 村上圭史, 菅原千恵子, 篠原千尋, 武川恵美, 三宅洋一郎, 松尾敬志, 河野文昭.
Organizer
第6回総合歯科学会総会
Place of Presentation
昭和大学, 東京
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