| Project/Area Number |
23390446
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
MURATA Hiroshi 長崎大学, 医歯(薬)学総合研究科, 教授 (40229993)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Masahiro 鹿児島大学, 医歯学総合研究科(歯学系), 教授 (00294570)
KOJIO Ken 長崎大学, 工学研究科, 准教授 (20346935)
HONG Guang 東北大学, 歯学研究科, 助教 (70363083)
TORISU Tetsurou 長崎大学, 病院, 講師 (80264258)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2011: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
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| Keywords | 歯学 / 高分子・物性 / 補綴用材料 / 粘膜調整材 / レオロジー / 動的粘弾性 / フッ素系モノマー / 高分子構造・物性 / 光触媒 / 粘膜調整剤 |
|---|
| Research Abstract |
The purpose of this research is to develop a fluorinated tissue conditioner with high durability and healing acceleration function by bioactive substances. The gelation characteristics, dynamic viscoelastic properties, their changes with time, solubility of components, and cytotoxicity were evaluated. The liquid component that showed high cytotoxicity was determined. The problems of current tissue conditioners were discussed. The system of three dimensional culture by gingival epithelia cell and gingival fibroblast was also developed. Subsequently, the efficacy of fluorinated monomers and healing acceleration were examined. The fluorinated monomers produced the materials having higher durability.
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