Structural equation modeling of interactions between serotonergic gene polymorphisms and environmental factors on sleep bruxism.
| Project/Area Number |
23390448
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUGANUMA Takeshi 昭和大学, 歯学部, 准教授 (10196694)
IGARASHI Yoshimasa 東京医科歯科大学, 医歯学総合研究科, 教授 (20107303)
NISHIYAMA Akira 東京医科歯科大学, 歯学部附属病院, 助教 (40359675)
KIUCHI Yuji 昭和大学, 歯学部, 教授 (50204821)
KINO Koji 東京医科歯科大学, 歯学部附属病院, 准教授 (80143585)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
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| Keywords | 睡眠時ブラキシズム / 構造方程式モデリング / 遺伝子多型 / SNP / SNPs / 共分散構造分析 / 5-HT / セロトニン2A受容体 / リスクファクター |
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| Research Abstract |
The aim of this study was to investigate the structural equation model of sleep bruxism associated with genetic and environmental factors and visualize the nature of sleep bruxism. 99 subjects were divided into sleep bruxism group (n=59) and control group (n=40) with the use of a clinical diagnostic criteria and 3 nights masseter EMG recording data. The environmental factors were explored with self-administered questionnaires. The genotype was determined on the polymorphism of SLC6A4, HTR1A, HTR2A and HTR2C. The modeling analysis found that an altered model of sleep bruxism related to 3 latent variables defined as sleep regulation, psychological stressor, and serotonergic system. The model elucidated that the R-square of sleep bruxism status was 0.24. The goodness-of-fit showed GFI= 0.910, adjusted GFI= 0.868, CFI= 0.992 and RMSEA= 0.022. These visualized results improve understanding of the distinct role of genetic and environmental latent variables on sleep bruxism.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Association of genetic, psychological and behavioral factors with sleep bruxism in a Japanese population2012
Author(s)
Abe Y, Suganuma T, Ishii M, Yamamoto G, Gunji T, Clark GT, Tachikawa T, Kiuchi Y, Igarashi Y, Baba K
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Journal Title
J Sleep Res
Volume: 21(3)
Issue: 3
Pages: 289-96
DOI
Related Report
Peer Reviewed
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[Presentation] 睡眠時ブラキシズム患者の睡眠構築について2013
Author(s)
葭澤秀一郎, 加藤隆史, 川名ふさ江, 酒井拓郎, 吉澤亜矢子, 小野康寛, 高場雅之, 栗原竜也, 石井正和, 菅沼岳史, 木内祐二, 馬場一美
Organizer
第32回昭和歯学会例会
Place of Presentation
東京
Year and Date
2013-12-01
Related Report
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[Presentation] 睡眠時ブラキシズム患者の睡眠構築について2013
Author(s)
葭澤 秀一郎, 加藤 隆史, 川名 ふさ江, 酒井 拓郎, 吉澤 亜矢子, 小野 康寛, 高場 雅之, 栗原 竜也, 石井 正和, 菅沼 岳史, 木内 祐二, 馬場 一美
Organizer
第 32 回昭和歯学会例会
Place of Presentation
東京
Related Report
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