| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Research Abstract |
The present study was designed to investigate the effect of calcium phosphate crystal characteristics on the bioactivity of the bone substitute materials. The spongy composite consists of synthetic octacalcium phosphate (OCP) and natural polymers, such as gelatin, was prepared. OCP crystals, ground mechanically from micrometer to nano-submicro meter scale in size, were dispersed in gelatin matrix and molded. The composite was soaked in simulated body fluid for one week or implanted in rat calvaria critical-sized defect for 8 weeks and then analyzed. X-ray diffraction of the soaked materials showed that hydroxyapatite became detected with the time. Histological analysis of the decalcified specimens of the calvaria indicated that new bone was formed together with the partial biodegradation of the materials. The results suggest that the crystal characteristics may be a factor to affect the bioactivity of the composite.
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