| Project/Area Number |
23390452
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Shinya 大阪大学, 大学院・歯学研究科, 教授 (70239490)
YAMASHITA Motozo 大阪大学, 歯学附属病院, 助教 (90524984)
TAKEDACHI Masahide 大阪大学, 大学院・歯学研究科, 助教 (60452447)
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| Research Collaborator |
YAMADA Satoru 大阪大学, 歯学附属病院, 講師 (40359849)
NOZAKI Takenori 大阪大学, 大学院・歯学研究科, 助教 (30263304)
YANAGITA Manabu 大阪大学, 大学院・歯学研究科, 助教 (80379081)
OZASA Masao 大阪大学, 歯学附属病院, 医員 (20624563)
KOJIMA Yuko 大阪大学, 大学院・歯学研究科, 特任研究員 (90632141)
SAWADA Keigo 大阪大学, 大学院・歯学研究科, 大学院生
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Keywords | FGF-2 / 歯周組織 / 再生療法 / 再生医療 |
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| Research Abstract |
To elucidate the possibility to the expansion of indications in the periodontal tissue regeneration using fibroblast growth factor-2 (FGF-2), we examined the longitudinal prognosis of FGF-2 application in the clinical trials. Furthermore, we evaluated the efficacy combining FGF-2 and adipose tissue- derived stem cells (ADSC) for periodontal tissue regeneration in the severe periodontal tissue defects of beagle dogs, and investigated the signal transduction following the FGF-2 stimulations in mouse periodontal ligament cells.
In result, the long-term safeties of FGF-2 application in human and the expansion of efficacy combining FGF-2 and ADSC for periodontal tissue regeneration in the severe periodontal tissue defects of beagle dogs were showed. In addition, it was clear that there were the intracellular signaling mechanisms governed by the cross talk between FGF-2 and vascular endothelial growth factor or bone morphogenetic protein 2 in the periodontal tissue regeneration.
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