A Challenge to the expansion of indications in periodontal tissue regeneration using FGF-2 by analyzing cross talk between signal molecules
| Project/Area Number |
23390452
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Shinya 大阪大学, 大学院・歯学研究科, 教授 (70239490)
YAMASHITA Motozo 大阪大学, 歯学附属病院, 助教 (90524984)
TAKEDACHI Masahide 大阪大学, 大学院・歯学研究科, 助教 (60452447)
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| Research Collaborator |
YAMADA Satoru 大阪大学, 歯学附属病院, 講師 (40359849)
NOZAKI Takenori 大阪大学, 大学院・歯学研究科, 助教 (30263304)
YANAGITA Manabu 大阪大学, 大学院・歯学研究科, 助教 (80379081)
OZASA Masao 大阪大学, 歯学附属病院, 医員 (20624563)
KOJIMA Yuko 大阪大学, 大学院・歯学研究科, 特任研究員 (90632141)
SAWADA Keigo 大阪大学, 大学院・歯学研究科, 大学院生
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Keywords | FGF-2 / 歯周組織 / 再生療法 / 再生医療 |
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| Research Abstract |
To elucidate the possibility to the expansion of indications in the periodontal tissue regeneration using fibroblast growth factor-2 (FGF-2), we examined the longitudinal prognosis of FGF-2 application in the clinical trials. Furthermore, we evaluated the efficacy combining FGF-2 and adipose tissue- derived stem cells (ADSC) for periodontal tissue regeneration in the severe periodontal tissue defects of beagle dogs, and investigated the signal transduction following the FGF-2 stimulations in mouse periodontal ligament cells.
In result, the long-term safeties of FGF-2 application in human and the expansion of efficacy combining FGF-2 and ADSC for periodontal tissue regeneration in the severe periodontal tissue defects of beagle dogs were showed. In addition, it was clear that there were the intracellular signaling mechanisms governed by the cross talk between FGF-2 and vascular endothelial growth factor or bone morphogenetic protein 2 in the periodontal tissue regeneration.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Periodontal tissue regeneration by transplantation of adipose tissue-derived multi-lineage progenitor cells2014
Author(s)
M Ozasa, K Sawada, T Iwayama, S Yamamoto, C Morimoto, H Okura, A Matsuyama, H Komoda, CM Lee, Y Sawa, M Kitamura, T Hashikawa, M Takedachi S Murakami
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Journal Title
Inflammation and Regeneration
Volume: 34
Pages: 109-116
NAID
Related Report
Peer Reviewed
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[Journal Article] 歯周炎罹患歯に対する FGF-2投与の長期的効果および安全性の検討2012
Author(s)
北村正博, 古市保志, 藤井健男, 川浪雅光, 國松和司, 島内英俊, 山田 了, 小方頼昌, 和泉雄一, 伊藤公一, 中川種昭, 新井 高, 山崎和久, 吉江弘正, 野口俊英, 渋谷俊昭, 高柴正悟, 栗原英見, 永田俊彦, 横田 誠, 前田勝正, 廣藤卓雄, 坂上竜資, 原 宜興, 野口和行, 小笠原健文, 村上伸也
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Journal Title
日歯周誌
Volume: 54
Pages: 38-45
NAID
Related Report
Peer Reviewed
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