| Project/Area Number |
23390453
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Dental engineering/Regenerative dentistry
|
|---|
| Research Institution | Tsurumi University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Tadao 福岡歯科大学, 再生医学研究センター, 教授 (80084250)
廣田 誠 横浜市立大学, 医学部, 准教授 (20347305)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HIROTA Makoto 横浜市立大学, 大学院・医学研究科, 准教授 (20347305)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2011: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
|
|---|
| Keywords | 歯科生体材料学 / 再生医学 / チタン / チタンファイバー / チタンワイヤー / タンパク質固定化 / コラーゲン / フィブロネクチン |
|---|
| Research Abstract |
In the present study, protein adsorption towards titanium was first analyzed by quartz-crystal microbalance method and attachment and proliferation of osteoblast-like cells on fibronectin immobilized titanium was also investigated. Afterwards, collagen or fibronectin was immobilized onto three-dimensional titanium fiber web and titanium wire by using tresyl chloride-activation method, and bone regeneration process towards titanium fiber web or titanium wire was evaluated by animal implantation experiments. As a result, it is suggested that protein immobilized titanium fiber web and titanium wire were useful as regenerative materials for jaw bone.
|
