development of implantable oseoinductive materials using polysaccharide and bone morphogenetic protein (BMP) combined 3D fabricated scaffold
| Project/Area Number |
23390454
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Hatsuhiko 愛知学院大学, 口腔病理学講座, 教授 (30175591)
TSURUTA Shozo 愛知学院大学, 歯科理工学講座, 准教授 (40183488)
HAYASHI Tatsuhide 愛知学院大学, 歯科理工学講座, 准教授 (70367621)
UENO Atsuko 愛知学院大学, 高齢者歯科学講座, 助教 (70469013)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 生体材料 / スキャフォールド / BMP / ３次元造形 / 3次元造形 / 生体材料学 / 金属 / 多糖類 |
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| Outline of Final Research Achievements |
Implantable metal frames that had mesh like shapes were formed by means of 3 dimensional direct manufacturing for metal (ARCAM). This equipment is an only one system that can produce 3 dimensional forming for metals using electron beam which enable to make no porosity of target products, eventually could achieved highest mechanical property.
Bone morphogenetic protein was combined on the surface of each 3 dimensional implant, then was implanted in the mouse. At 3 weeks after implantation, new bone formation was observed. When adequate pore size of mesh was formed in the implant, new bone formation was occurred not only on the surface of embedded implant but also inside of the mesh area of the implant. Dextrin showed excellent property as a carrier of recombinant BMP to scaffold. Consequently, the developed system in this project could applicable as a new method for clinical application in dentistry, orthopedics and other medical areas in near future.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Biocompatibility of Nylon Resin Dises Fabricated by Selective Laser Sintering2013
Author(s)
Akiko ABE,Shuichiro KOBAYASHI,Hironari FUYAMADA,Daisuke YAMAGUCHI,Shingo MATSUMURA,Atsuko UENO,Yoshinori NAKAMURA,Kazuo TAKEUCHI,Hiroshi MURAKAMI,Tatsushi KAWAI,and Masami HATTORI
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Journal Title
J of Oral Tissue Engin
Volume: 11(1)
Pages: 42-50
Related Report
Peer Reviewed
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[Presentation] EPITHELIAL CELL BIOCOMPATIBILITY TO ZIRCONIA,TITANIUM,AND ALUMINA2013
Author(s)
E.Okabe,K.Sasaki,S.Kobayashi,H.Mizutani,A.Izawa,H.Goto,S.Ban,Y.Ishihara,T.Kawai and T.Noguchi
Organizer
13th Asian BioCeramics Symposium
Place of Presentation
京都
Related Report
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