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development of implantable oseoinductive materials using polysaccharide and bone morphogenetic protein (BMP) combined 3D fabricated scaffold

Research Project

Project/Area Number 23390454
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionAichi Gakuin University

Principal Investigator

KAWAI Tatsushi  愛知学院大学, 歯学部, 教授 (60167351)

Co-Investigator(Kenkyū-buntansha) MAEDA Hatsuhiko  愛知学院大学, 口腔病理学講座, 教授 (30175591)
TSURUTA Shozo  愛知学院大学, 歯科理工学講座, 准教授 (40183488)
HAYASHI Tatsuhide  愛知学院大学, 歯科理工学講座, 准教授 (70367621)
UENO Atsuko  愛知学院大学, 高齢者歯科学講座, 助教 (70469013)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywords生体材料 / スキャフォールド / BMP / 3次元造形 / 3次元造形 / 生体材料学 / 金属 / 多糖類
Outline of Final Research Achievements

Implantable metal frames that had mesh like shapes were formed by means of 3 dimensional direct manufacturing for metal (ARCAM). This equipment is an only one system that can produce 3 dimensional forming for metals using electron beam which enable to make no porosity of target products, eventually could achieved highest mechanical property.
Bone morphogenetic protein was combined on the surface of each 3 dimensional implant, then was implanted in the mouse. At 3 weeks after implantation, new bone formation was observed. When adequate pore size of mesh was formed in the implant, new bone formation was occurred not only on the surface of embedded implant but also inside of the mesh area of the implant. Dextrin showed excellent property as a carrier of recombinant BMP to scaffold. Consequently, the developed system in this project could applicable as a new method for clinical application in dentistry, orthopedics and other medical areas in near future.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (31 results)

All 2014 2013 2012 2011

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (17 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Utility of Porototype Porous Titanium as a Bone Regeneration Scaffold2013

    • Author(s)
      Teruo HIGA,Atsuko UENO,Tatsuhide HAYASHI,Akiko ABE,Yuzo OHNO,Tatsushi KAWAI and Kenichi KURITA
    • Journal Title

      Oral Tissue Engin

      Volume: 10(3) Pages: 163-171

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of heat treatment conditions on the mechanical properties of Ti-6Mo-4Sn alloy for orthodontic wires2013

    • Author(s)
      Mayu HIDA,Ken MIYAZAWA,Shozo TSURUTA,Masahiro KUROSAWA,Yuki HATA,Tatsushi KAWAI and Shigemi GOTO
    • Journal Title

      Dent Mater J

      Volume: 32(3) Pages: 462-467

    • NAID

      10031158848

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-Term Observation of Ectopic Bone Formation Using In Vivo Microcomputed Tomography2013

    • Author(s)
      Yamato Sato,Tatsuhide Hayashi,Souichiro Hamazima,Masaki Asakura,Akiko Abe and Tatsushi Kawai
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: Vol.22(3) Pages: 343-350

    • NAID

      130004480601

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-Dimensional Analysis and Longitudinal Observation for Osteoinductivity Induced by Bone Morphogenetic Protein2013

    • Author(s)
      Hiroyuki OKEYA,Masaki ASAKURA,Tatsuhide HAYASHI,Atsuko UENO,Masamtsu ITO,Yozo OHNO,Tatsushi KAWAI and Toshihide NOGUCHI
    • Journal Title

      Oral Tissue Engin

      Volume: 11(1) Pages: 1-8

    • NAID

      130004941093

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biocompatibility of Nylon Resin Dises Fabricated by Selective Laser Sintering2013

    • Author(s)
      Akiko ABE,Shuichiro KOBAYASHI,Hironari FUYAMADA,Daisuke YAMAGUCHI,Shingo MATSUMURA,Atsuko UENO,Yoshinori NAKAMURA,Kazuo TAKEUCHI,Hiroshi MURAKAMI,Tatsushi KAWAI,and Masami HATTORI
    • Journal Title

      J of Oral Tissue Engin

      Volume: 11(1) Pages: 42-50

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A NEWLY DEVELOPED SEALER CONTANING ANATASE-TYPE TITANIUM OXIDE2012

    • Author(s)
      AyumiNakamura.et al
    • Journal Title

      Aichi Gakuin Dent Sci

      Volume: 25 Pages: 17-23

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect levels in a gold-based alloy on porcelain-metal bonding.2012

    • Author(s)
      Asakura,M.et al
    • Journal Title

      Dental Materials Journal

      Volume: 28 Pages: 35-41

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro biocompatibility of dextrin : the addition of a low-concentration of dextrin in the medium promotes the cell activity of L929 mouse fibroblasts2011

    • Author(s)
      Asai, T., et al
    • Journal Title

      Cell Biology International

      Volume: 35 Issue: 6 Pages: 645-648

    • DOI

      10.1042/cbi20100264

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of notch signaling molecules in ameloblastomas2011

    • Author(s)
      E.Muraki, et al
    • Journal Title

      European Journal of Medical Research

      Volume: 16(6) Pages: 253-257

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Tooth Surface Elements by Ion Beam Analysis2011

    • Author(s)
      Victoria Glauche, et al
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 20(2) Pages: 99-106

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase Transformation and Corrosion Properties of Surface Oxidized NiTi Shape Memory Alloy2011

    • Author(s)
      Qiang Wang, et al
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 20(3) Pages: 169-176

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Characteristics of Epithelial Cell Attachment to Zirconia Similar to Titanium2013

    • Author(s)
      Y.ISHIHARA,E.OKABE,K.SASAKI,S.KOBAYASHI,H.MIZUTANI,A.IZAWA,H.GOTO,S.BAN,H.MURAKAMI,T.KAWAI and T.NOGUCHI
    • Organizer
      Meeting of the International Association for Dental Research-Asia Pacific Region
    • Place of Presentation
      Thailand
    • Related Report
      2013 Annual Research Report
  • [Presentation] 金属系三次元スキャフォールドrhBMP-2の複合化による骨誘導2013

    • Author(s)
      普山田宏成,宮前真,松村亜希子,上野温子,林達秀,河合逹志,服部正巳
    • Organizer
      第62回日本歯科理工学会学術講演会
    • Place of Presentation
      新潟
    • Related Report
      2013 Annual Research Report
  • [Presentation] rhBMP-2 induces immature muscular tissue to differentiate into bone-like tissue in vitro2013

    • Author(s)
      T.Hayashi,K.Yoshihara,M.Kawase,A.Mieki,S.Hamajima,T.Kawai
    • Organizer
      BIOCERAMICS 25
    • Place of Presentation
      Romania
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス線維芽細胞様細胞および骨芽細胞様細胞のTi-6Al-4V合金シート上での増殖能2013

    • Author(s)
      川瀬真由,林達秀,佐々雅祥,中野禅,萩原正,清水透,河合逹志
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] EPITHELIAL CELL BIOCOMPATIBILITY TO ZIRCONIA,TITANIUM,AND ALUMINA2013

    • Author(s)
      E.Okabe,K.Sasaki,S.Kobayashi,H.Mizutani,A.Izawa,H.Goto,S.Ban,Y.Ishihara,T.Kawai and T.Noguchi
    • Organizer
      13th Asian BioCeramics Symposium
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 金属系三次元スキャホールドの開発2012

    • Author(s)
      普山田宏成,他
    • Organizer
      第59回日本歯科理工学会学術講演会
    • Place of Presentation
      あわぎんホール(徳島)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 電子ビーム粉末積層造形法を用いたチタン製三次元多孔質スキャホールドの開発2012

    • Author(s)
      普山田宏成,他
    • Organizer
      第29回日本顎顔面補綴学会学術大会
    • Place of Presentation
      愛知学院大学(愛知)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Promotion of rat calvarial defect healing by induced bone-link tissue.2012

    • Author(s)
      Hayashi,T.et al
    • Organizer
      90th General Session of the IADR
    • Place of Presentation
      Iguacu Falls(Brazil)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Possibility of Sintered Titanium Dioxide as a Bone Filling Material.2012

    • Author(s)
      Asai,T.et al
    • Organizer
      90th General Session of the IADR
    • Place of Presentation
      Iguacu Falls(Brazil)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bone-like tissue induced by rhBMP-2,rhBMP-4 and rhBMP-7 in vitro has ossification potential after implantation.2012

    • Author(s)
      Hayashi,T.et al
    • Organizer
      TERMIS World Congress2012
    • Place of Presentation
      Hofburg Congress Centre
    • Related Report
      2012 Annual Research Report
  • [Presentation] レジンモノマーの解毒酵素遺伝子発現誘導能の解析2012

    • Author(s)
      折本愛,他
    • Organizer
      第81回愛知学院大学歯学会
    • Place of Presentation
      愛知学院大学(愛知)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 歯内療法領域における術前シュミレーションへの3次元造形模型の可能性2012

    • Author(s)
      加藤彰子,他
    • Organizer
      第81回愛知学院大学歯学会
    • Place of Presentation
      愛知学院大学(愛知)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 未成熟筋組織-rhBMP-ePTFEによる骨誘導の可能性2011

    • Author(s)
      林達秀, 他
    • Organizer
      第33回日本バイオマテリアル学会
    • Place of Presentation
      京都
    • Year and Date
      2011-11-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 汎用USB I/O基板の応用第2報実測定例2011

    • Author(s)
      河合達志
    • Organizer
      日本歯科理工学会中部支部夏期セミナー
    • Place of Presentation
      秋田
    • Year and Date
      2011-08-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 光重合型コンポブットレジンの重合発熱に関する基礎的研究-第1報測定系の確立-2011

    • Author(s)
      江頭美喜, 他
    • Organizer
      第78回愛知学院大学歯学会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-06-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Osteoinductive activity of BMP-Metal composite material2011

    • Author(s)
      Ueda, N., et al
    • Organizer
      The international dental materials congress 2011
    • Place of Presentation
      Seoul
    • Year and Date
      2011-05-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Surface analysis of titanium influenced by plasma glow discharge2011

    • Author(s)
      Muraji, N., et al
    • Organizer
      The international dental materials Congress 2011
    • Place of Presentation
      Seoul
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 骨形成促進材2014

    • Inventor(s)
      河合達志(他5名)
    • Industrial Property Rights Holder
      河合達志(他5名)
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-019237
    • Filing Date
      2014-02-04
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞増殖用材料、組織再生膜及び組織再生方法2013

    • Inventor(s)
      河合達志(他6名)
    • Industrial Property Rights Holder
      河合達志(他6名)
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-12-09
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 骨形成因子・金属スキャフォールド複合体2012

    • Inventor(s)
      河合達志, 他3名
    • Industrial Property Rights Holder
      学校法人愛知学院
    • Filing Date
      2012-03-15
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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