Osteogenesis by gradually expanding the interface between bone surface and periosteum

• Project/Area Number: 23390458
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tohoku University
• Principal Investigator: KAWAMURA HIROSHI 東北大学, 歯学研究科(研究院), 大学院非常勤講師 (00110651)
• Co-Investigator(Kenkyū-buntansha): NARUSHIMA Takayuki 東北大学, 大学院・工学研究科, 教授 (20198394)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
• Keywords: 骨膜伸展 / 自家骨再生 / デンタルインプラント / 薄膜コーティング / 非晶質リン酸カルシウム / RFマグネトロンスパッタリング / チタン / 薄膜コーッティング / 再生骨

Research Abstract

We are investigating to regenerate bone by osteogenesis using gradually expanding the interface between bone surface and periosteum. In this study we developed the new dental implant system to obtain quick and broad adherence to surrounding bone to use for the regenerated bone. We evaluated thin amorphous calcium phosphate films coated on the surface of titanium dental implants using magnetron sputtering. The coated thin amorphous phosphate films induced early not only distance osteogenesis from the bone surrounding implants but also inner osteogenesis in the surface layers of the films. The implants showed early good mechanical fixation.These results suggested that implants coated with thin amorphous phosphate layers improve implant fixation and accelerate bone response.

Research Products

• [Journal Article] Evaluation of thin amorphous calcium phosphate coatings on titanium dental implants deposited using magnetron sputtering. (2014)
  • Author(s): Yokota S, Nishiwaki N, Ueda K, Narushima T, Kawamura H, Takahashi T.
  • Journal Title: Implant Dentistry Volume: 23 Issue: 3 Pages: 343-350
  • DOI: 10.1097/id.0000000000000098
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice (2014)
  • Author(s): Yagishita Y, Fukutomi T, Sugawara A, Kawamura H, Takahashi T, Pi J, Uruno A, and Yamamoto M.
  • Journal Title: Diabetes Volume: 63 Issue: 2 Pages: 605-618
  • DOI: 10.2337/db13-0909
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Facilitating ramus lengthening following mandibular-dependent surgical closing of a skeletal open bite with short ramus : a new modified technique (2012)
  • Author(s): Z Aymach, H Kawamura
  • Journal Title: J Craniomaxillofac Surg Volume: 40(2) Issue: 2 Pages: 169-72
  • DOI: 10.1016/j.jcms.2011.03.015
  • Peer Reviewed
• [Journal Article] Non-surgical correction of skeletal open bite : A goal-oriented approach evaluate by CBCT (2011)
  • Author(s): J Sugawara, Z Aymach, H Nagsaka, H Kawamura, R Nanda
  • Journal Title: J Clin Orthod Volume: 45(3) Pages: 145-155
  • Peer Reviewed
• [Journal Article] Evaluation of skeletal stability after surgical-orthodontic correction of skeletal open bite with mandibualr counterclockwise rotation using modified inverted L osteotomy (2011)
  • Author(s): Z Aymach, H Nei, H Kawamura, J Van Sickels
  • Journal Title: J Oral Maxillofac Surg Volume: 6(3) Pages: 853-860
  • Peer Reviewed
• [Journal Article] Biomechanical evaluation of a T-shaped miniplate fixation of a modified sagittal split ramus osteotomy with buccal step. a new technique for mandibular orthognathic surgery (2011)
  • Author(s): Z Aymach, H Nei, H Kawamura, W Bell
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Rdiol Endod Volume: 111(1) Pages: 58-63
  • Peer Reviewed
• [Presentation] 上顎変形の問題解決に挑むMaxillary Osteotomies (2013)
  • Author(s): 川村 仁
  • Organizer: 日本口腔外科学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2013-10-12
• [Presentation] RF マグネトロンスパッタリング法による非晶質リン酸カルシウムコーティングの評価 (2012)
  • Author(s): 橫田 聡, 川村 仁, 成島 尚之, 他
  • Organizer: 日本顎顔面インプラント学会学術大会
  • Place of Presentation: 北九州市
  • Year and Date: 2012-12-01
• [Presentation] 多様な上顎変形に対応するためのLe Fort I型骨切り術をコントロールする (2012)
  • Author(s): 川村 仁
  • Organizer: 日本口腔外科学会学術大会
  • Place of Presentation: 横浜
  • Year and Date: 2012-10-20
• [Presentation] RFマグネトロンスパッタリング法による非晶質リン酸カルシウムコーティングの評価 (2012)
  • Author(s): 横田聡、栗原淳、西脇成彦、玉手総一郎、上田恭介、成島尚之、川村仁、高橋哲
  • Organizer: 第16回日本顎顔面インプラント学会
  • Place of Presentation: 北九州国際会議場
• [Presentation] デンタルインプラントへの非晶質リン酸カルシウム(ACP)コーティングの生体内評価 (2011)
  • Author(s): 横田聡, 栗原淳, 川村仁
  • Organizer: 第15回日本顎顔面インプラント学会総会・学術大会
  • Place of Presentation: 幕張メッセ千葉市
  • Year and Date: 2011-12-04
• [Presentation] 顎変形を改善するための上顎骨骨切り術を考える-Le FortI型骨切り術を中心に- (2011)
  • Author(s): 川村 仁
  • Organizer: 日本口腔外科学会体会
  • Place of Presentation: 大阪
  • Year and Date: 2011-10-22
• [Presentation] インプラントへのRFマグネトロンスパッタリング法による非晶質CaPコーティングの評価 (2011)
  • Author(s): 横田聡, 栗原淳, 西脇成彦, 上田恭介, 成島尚之, 川村仁
  • Organizer: 第56回(社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 大阪国際会議場大阪市
  • Year and Date: 2011-10-22
• [Book] Esthetics and Biomechanics in Orthodontics : Surgery First : The Protocol of Innovative Surgery Orthodontics, Second Edition (2014)
  • Author(s): Sugawara, Z Aymach, S Yamaguchi, H Nagasaka, H Kawamura, and R Nanda
  • Publisher: ELSVEIER