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Examination of hybrid bone grafts using nano DDS and artificial bones

Research Project

Project/Area Number 23390459
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionThe University of Tokyo

Principal Investigator

MORI Yoshiyuki  東京大学, 医学部附属病院, 准教授 (70251296)

Co-Investigator(Kenkyū-buntansha) SAIJO Hideto  東京大学, 医学部附属病院, 講師 (80372390)
TEI Yuichi  東京大学, 工学系研究科, 教授 (30345053)
YANO Fumiko  東京大学, 医学系研究科, 特任助教 (80529040)
Co-Investigator(Renkei-kenkyūsha) KATAOKA Kazunori  東京大学, 工学系研究科, 教授 (00130245)
OGASAWARA Toru  東京大学, 医学部附属病院, 講師 (20359623)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2011: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Keywords骨再生用移植片 / 骨再生 / 生理活性物質 / 骨移植片 / ナノDDS
Research Abstract

By further integrating research that we had performed, this study was aimed to develop hybrid-type bone grafts for bone regeneration that were efficiently replaced into bone tissues. We identified osteogenic genes and bioactive factors with the bio-sensor and developed the osteogenic differentiation protocol using the nano drug delivery of the genes and factors. Focusing on iPS cells as a cell source for bone regeneration, we attempted to establish an in vitro differentiation protocol from the cells. Finally, we generated hybrid-type bone grafts that consisted of artificial bones and osteoblastic cells generated from stem cells, and examined their bone healing ability in animal experiments.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (51 results)

All 2014 2013 2012 2011 Other

All Journal Article (23 results) (of which Peer Reviewed: 10 results,  Open Access: 1 results) Presentation (23 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Implantation of tetrapod-shaped granular artificial bones or β-tricalcium phosphate granules in a canine large bone-defect model2014

    • Author(s)
      Choi S, Liu I, Yamamoto K, Honnami M, Sakai T, Ohba S, Echigo R, Suzuki S, Chung UI, Sasaki N, Mochizuki M
    • Journal Title

      J Vet Med Sci

      Volume: 76(2) Pages: 229-235

    • Related Report
      2013 Final Research Report
  • [Journal Article] Repair of rabbit segmental femoral defects by using a combination of tetrapod-shaped granular artificial bones and basic fibroblast growth factor-binding ion complex gel2013

    • Author(s)
      Honnami M, Choi S, Liu I, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M
    • Journal Title

      Biomaterials

      Volume: 34(36) Pages: 9056-9062

    • Related Report
      2013 Final Research Report
  • [Journal Article] Generation of Col2a1-EGFP iPS cells for monitoring chondrogenic differentiation2013

    • Author(s)
      Saito T, Yano F, Mori D, Ohba S, Hojo H, Otsu M, Eto K, Nakauchi H, Tanaka S, Chung UI, Kawaguchi H
    • Journal Title

      PLoS ONE

      Volume: 8(9)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 by modulating bone morphogenetic protein (BMP) signaling2013

    • Author(s)
      Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung UI, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, Hoshi K
    • Journal Title

      J Cell Physiol

      Volume: 228(1) Pages: 163-171

    • Related Report
      2013 Final Research Report
  • [Journal Article] Submucous cleft palate : variations in bony defects of the hard palate2013

    • Author(s)
      Mori Y, Hoshi K, Takato T, Takahashi M, Hirano Y, Kanno Y, Ohkubo K, Saijo H
    • Journal Title

      Br J Oral Maxillofac Surg

      Volume: 51

    • Related Report
      2013 Final Research Report
  • [Journal Article] Usefulness of agarose mold as a storage container for three-dimensional tissue-engineered cartilage2013

    • Author(s)
      Mori Y, Kanazawa S, Watanabe M, Suenaga H, Nagata S, Fujihara Y, Takato T, Hoshi K
    • Journal Title

      Mater Sci Appl

      Volume: 4(8) Pages: 73-73

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Hollow fiber module applied for effective proliferation and harvest of cultured chondrocytes2013

    • Author(s)
      Mori Y, Watanabe M, Nakagawa S, Asawa Y, Nishizawa S, Saijo H, Nagata S, Fujihara Y, Takato T, Hoshi K
    • Journal Title

      Mater Sci Appl

      Volume: 4(8) Pages: 62-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] Clinical presentation of epignathus teratoma with cleft palate ; and duplication of cranial base, tongue, mandible, and pituitary gland2013

    • Author(s)
      Maeda Y, Suenaga H, Sugiyama M, Saijo H, Hoshi K, Mori Y, Takato T
    • Journal Title

      J Craniofac Surg

      Volume: 24(4) Pages: 1486-91

    • Related Report
      2013 Final Research Report
  • [Journal Article] Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 by modulating bone morphogenetic protein(BMP) signaling.2013

    • Author(s)
      Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung UI, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, and Hoshi K
    • Journal Title

      J Cell Physiol

      Volume: (in press) Issue: 1 Pages: 163-71

    • DOI

      10.1002/jcp.24116

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hollow fiber module applied for effective proliferation and harvest of cultured chondrocytes.2013

    • Author(s)
      Mori Y, Watanabe M, Nakagawa S, Asawa Y, Nishizawa S, Saijo H, Nagata S, Fujihara Y, Takato T, Hoshi K
    • Journal Title

      Mater Sci Appl

      Volume: 4 Issue: 08 Pages: 62-67

    • DOI

      10.4236/msa.2013.48a008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Submucous cleft palate: variations in bony defects of the hard palate.2013

    • Author(s)
      Mori Y, Hoshi K, Takato T, Takahashi M, Hirano Y, Kanno Y, Ohkubo K, Saijo H
    • Journal Title

      Br J Oral Maxillofac Surg.

      Volume: 51 Issue: 8 Pages: 220-223

    • DOI

      10.1016/j.bjoms.2013.01.015

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of Col2a1-EGFP iPS cells for monitoring chondrogenic differentiation2013

    • Author(s)
      Saito T, Yano F, Mori D, Ohba S, Hojo H, Otsu M, Eto K, Nakauchi H, Tanaka S, Chung UI, Kawaguchi H
    • Journal Title

      PLoS One

      Volume: 16;8(9) Issue: 9 Pages: e74137-e74137

    • DOI

      10.1371/journal.pone.0074137

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical presentation of epignathus teratoma with cleft palate; and duplication of cranial base, tongue, mandible, and pituitary gland.2013

    • Author(s)
      Maeda Y, Suenaga H, Sugiyama M, Saijo H, Hoshi K, Mori Y, Takato T
    • Journal Title

      J Craniofac Surg.

      Volume: 24 Issue: 4 Pages: 1486-91

    • DOI

      10.1097/scs.0b013e3182953b1f

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bone healing by sterilizable calcium phosphate tetrapods eluting osteoge nic molecules.2013

    • Author(s)
      Maeda Y, Hojo H, et al.
    • Journal Title

      Biomaterials

      Volume: 34 Issue: 22 Pages: 5530-5537

    • DOI

      10.1016/j.biomaterials.2013.03.089

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and evaluation of tetrapod-shaped granular artificial bones2012

    • Author(s)
      Choi S, Liu IL, Yamamoto K, Igawa K, Mochizuki M, Sakai T, Echigo R, Honnami M, Suzuki S, Chung UI, Sasaki N
    • Journal Title

      Acta Biomater

      Volume: 8(6) Pages: 2340-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mandibular body ostectomy for correction of mandibular prognathism - a technical note2012

    • Author(s)
      Mori Y, Susami T, Saijo H, Okubo K, Uchino N, Hoshi K, Takato T
    • Journal Title

      Oral Sci Int

      Volume: 9(1) Pages: 21-25

    • NAID

      10031144844

    • Related Report
      2013 Final Research Report
  • [Journal Article] The efficacy of dental therapy for an adult case of Henoch-Schönlein Purpura2012

    • Author(s)
      Abe M, Mori Y, Saijo H, Hoshi K, Ohkubo K, Ono T, Takato T
    • Journal Title

      Oral Sci Int

      Volume: 9(2) Pages: 59-62

    • Related Report
      2013 Final Research Report
  • [Journal Article] Facial morphology and occlusion of a patient with fibrodysplasia ossificans progressiva (FOP): a case report.2012

    • Author(s)
      Takahumi Susami
    • Journal Title

      Special Care in Dentistry

      Volume: 32 Issue: 4 Pages: 165-170

    • DOI

      10.1111/j.1754-4505.2012.00260.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and evaluation of tetrapod-shaped granular artificial bones2012

    • Author(s)
      Sungjin Choi
    • Journal Title

      Acta Biomaterialia

      Volume: (掲載確定済) Issue: 6 Pages: 2340-2347

    • DOI

      10.1016/j.actbio.2012.02.019

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The development of a serum-free medium utilizing the interaction between growth factors and biomaterials2012

    • Author(s)
      Kumiko Iwata
    • Journal Title

      Biomaterials

      Volume: 33(2) Issue: 2 Pages: 444-454

    • DOI

      10.1016/j.biomaterials.2011.09.056

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extraction of 6 molars under general anesthesia in patient with fibrodysplasia ossificans progressiva2011

    • Author(s)
      Mori Y, Susami T, Haga N, Tamura K, Kanno Y, Saijo H, Takato T
    • Journal Title

      J Oral Maxillofac Surg

      Volume: 69(7) Pages: 1905-10

    • Related Report
      2013 Final Research Report
  • [Journal Article] Extraction of 6 molars under general anesthesia in patient with fibrodysplasia ossificans progressiva2011

    • Author(s)
      Yoshiyuki Mori
    • Journal Title

      Journal of Oral and Maxillofacial Surgery

      Volume: 69(7) Issue: 7 Pages: 1905-1910

    • DOI

      10.1016/j.joms.2010.12.011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone regeneration by the combined use of tetrapod-shaped calcium phosphate granules with basic fibroblast growth factor-binding ion complex gel in canine segmental radial defects

    • Author(s)
      Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M
    • Journal Title

      J Vet Med Sci

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Presentation] Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions2013

    • Author(s)
      Kanke K, Saito S, Hojo H, Lichtler AC, Chung UI, Ohba S
    • Organizer
      Cell symposia 2013- Stem cells to model and treat human disease
    • Place of Presentation
      Los Angeles, CA, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Stepwise differentiation of pluripotent stem cells into osteoblasts with four small molecules under a serum-free condition2013

    • Author(s)
      Kanke K, Saito T, Hojo H, Lichtler AC, Chung UI, Ohba S
    • Organizer
      35th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Baltimore, MD, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Novel approach for the differentiation of embryonic stem cells into osteoblasts under a chemically-defined condition2013

    • Author(s)
      Kanke K, Hojo H, Lichtler AC, Chung UI, Ohba S
    • Organizer
      2nd Joint Meeting of the International Bone and Mineral Society and The Japanese Society for Bone and Mineral Research
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Outcome of the surgical-orthodontic treatment in patients with clefts using the two-stage surgery combining maxillary distraction with mandibular setback osteotomies2013

    • Author(s)
      Mori Y, Susami T, Saijo H, Uchino N, Ohkubo K, Inokuchi T, Okayasu M, Uwatoko K, Hoshi K, Takato T
    • Organizer
      12th International Congress on Cleft Lip/Palate and Related Craniofacial Anomalies
    • Place of Presentation
      Florida USA , Hilton Orlando Lake Buena Vista
    • Related Report
      2013 Final Research Report
  • [Presentation] in situ Tissue Engineering 型カスタムメイド人工骨の骨癒合状態のCT による評価2013

    • Author(s)
      菅野勇樹, 西條英人 , 鄭雄一, 森良之, 高戸毅
    • Organizer
      第58回日本口腔外科学会総会・学術大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Outcome of the surgical-orthodontic treatment in patients with clefts using the two-stage surgery combining maxillary distraction with mandibular setback osteotomies2013

    • Author(s)
      Mori Y, Susami T, Saijo H , Uchino N, Ohkubo K, Inokuchi T, Okayasu M, Uwatoko K, Hoshi K, Takato T
    • Organizer
      12th International Congress on Cleft Lip/Palate and Related Craniofacial Anomalies
    • Place of Presentation
      Florida, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Postoperative evaluation of custom-made artificial bones fabricated by inkjet printers using computed tomography2013

    • Author(s)
      Kanno Y, Saijo H, Mori Y, Chung UI, Takato T
    • Organizer
      Frontiers 2013 EPFL Symposium
    • Place of Presentation
      Lausanne, Switzerland
    • Related Report
      2013 Annual Research Report
  • [Presentation] Need for orthognathic sugery and its prediction in early mixed dentition in patients with bilateral cleft lip and palate.2013

    • Author(s)
      Okayasu M , Susami T , Inocuchi T , Ohkubo K , Uchino N , Uwatoko K , Ogasawara T , Ssaijo H , Mori Y , Takato T
    • Organizer
      12th International Congress on Cleft Lip/Palate and Related Craniofacial Anomalies
    • Place of Presentation
      Florida, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Palatal index for evaluation of the palatal morphology in patients with uniateral cleft lip and palate2013

    • Author(s)
      Inokuchi T, Susami T, Okayasu M, Uchino N, Uwatoko K, Ohkubo K, Ogasawara T, Saijo H, Mori Y, Takato T
    • Organizer
      12th International Congress on Cleft Lip/Palate and Related Craniofacial Anomalies
    • Place of Presentation
      Florida, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 口腔扁平上皮癌の発生過程においてサイレンシングされる遺伝子のゲノム網羅的探索2013

    • Author(s)
      阿部雅修, 森良之, 安部貴大, 末永英之, 古賀陽子, 瀬戸一郎, 西條英人, 星和人, 髙戸毅
    • Organizer
      第67回日本口腔科学会総会
    • Place of Presentation
      栃木(栃木県総合文化センター )
    • Related Report
      2013 Annual Research Report
  • [Presentation] in situ Tissue Engineering型カスタムメイド人工骨の骨癒合状態のCTによる評価2013

    • Author(s)
      菅野勇樹,西條英人 ,鄭雄一, 森良之 ,高戸毅
    • Organizer
      第58回日本口腔外科学会総会・学術大会
    • Place of Presentation
      福岡(福岡国際会議場)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gli1 Participates in the Indian Hedgehog-mediated Osteogenesis during Endochondral Ossification2012

    • Author(s)
      Hojo H, Ohba S, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata H, Suzuki K, Takato T, Kawaguchi H, Chung UI
    • Organizer
      34th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Minneapolis, MN, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Osteo-chondrogenic Function of BMP is Directed Toward Osteogenesis by Hh-Gli1 in the Perichondrium2012

    • Author(s)
      Hojo H, Ohba S, Taniguchi K, Shirai M, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Mishina Y, Yamada M, Konno T, Takato T, Kawaguchi H, Kambara H, Chung UI
    • Organizer
      34th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Minneapolis, MN, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Prevention and Repair of Cartilage Degeneration by a Novel Small Thienoindazole-derivative Compound2012

    • Author(s)
      Yano F, Hosaka Y, Fukai A, Saito T, Hojo H, Ohba S, Kawaguchi H, Chung UI
    • Organizer
      2012 World Congress on Osteoarthritis
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] 下顎枝矢状分割術における超音波骨切削器(ピエゾサージェリーシステム[〇!R])を用いたShort lingual osteotomy (SLO)2012

    • Author(s)
      森良之, 末永英之, 古賀陽子, 菅野勇樹, 杉山円, 瀬戸一郎, 西條英人, 星和人, 高戸毅
    • Organizer
      第57回(公社)日本口腔外科学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜会議センター, 神奈川県横浜市
    • Related Report
      2013 Final Research Report
  • [Presentation] 下顎枝矢状分割術における超音波骨切削器(ピエゾサージェリーシステム®)を用いたShort lingual osteotomy (SLO).2012

    • Author(s)
      森良之
    • Organizer
      第57回日本口腔外科学会総会・学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 上下顎手術における骨延長術の役割.2012

    • Author(s)
      森良之
    • Organizer
      第38回日本口腔外科学会教育研修会 口腔四学会合同研修会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Nanogの間葉系細胞骨分化能促進効果はBMPシグナルとの相互作用とNFATc1の誘導を介する.2012

    • Author(s)
      小笠原徹
    • Organizer
      第57回日本口腔外科学会総会・学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] チタンメッシュトレーを用いた海綿骨細片(PCBM)による二次的下顎顎骨再建後にインプラントを用いて咬合回復を行なった1例2012

    • Author(s)
      杉山円
    • Organizer
      第67回日本口腔科学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report
  • [Presentation] 当科における生体内吸収性PLLA/HA骨接合プレート(Super Fixsorb MX) 治療成績とその合併症.2012

    • Author(s)
      瀬戸一郎
    • Organizer
      第57回日本口腔外科学会総会・学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 口腔前癌病変悪性化におけるエピジェネティクスを指標としたリスクマーカーのゲノム網羅的探索2011

    • Author(s)
      阿部雅修, 森良之, 西條英人, 安部貴大, 杉山円, 古賀陽子, 高戸毅
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      ウィンクあいち, 名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] A 2-stage surgery combining mandibular distraction with a Le Fort I maxillary osteotomy in a patient with hemifacial microsomia2011

    • Author(s)
      Mori Y, Susami T, Saijo H, Ohkubo K, Kanno Y, Suenaga H, Seto I, Hoshi K, Takato T
    • Organizer
      9th European Craniofacial Congress
    • Place of Presentation
      Salzburg, Austria, Salzburg Congress
    • Related Report
      2013 Final Research Report
  • [Presentation] A 2-stage surgery combining mandibular distraction with a Le Fort I maxillary osteotomy in a patient with hemifacial microsomia2011

    • Author(s)
      Yoshiyuki Mori
    • Organizer
      9th European Craniofacial Congress
    • Place of Presentation
      Salzburg, Austria
    • Related Report
      2011 Annual Research Report
  • [Book] 「15章消化器疾患 5口腔疾患」内科学, 門脇孝・永井良三総編集2012

    • Author(s)
      森良之・高戸毅
    • Publisher
      西村書店(東京)
    • Related Report
      2013 Final Research Report
  • [Book] 「15章消化器疾患 5口腔疾患」内科学(門脇孝・永井良三編)2012

    • Author(s)
      森良之
    • Total Pages
      1929
    • Publisher
      西村書店
    • Related Report
      2012 Annual Research Report
  • [Remarks] 東京大学医学部附属病院顎口腔外科・歯科矯正歯科ホームページ

    • URL

      http://plaza.umin.ac.jp/~oralsurg/

    • Related Report
      2013 Final Research Report
  • [Remarks] 東京大学医学部附属病院 顎口腔外科・歯科矯正歯科

    • URL

      http://plaza.umin.ac.jp/~oralsurg/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/~oralsurg/

    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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