| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Research Abstract |
In this study, we found three findings. First, lymphocytic infiltration in the Sjogren's syndrome salivary glands was achieved by the translocalization of 5-a-reductase from the nucleus to cytoplasm. Second, destruction of acinar structure of Sjogren's syndrome salivary gland was induced by the activation of MMP-9 by TNF-a. Third, salivary duct cells lacking the expression of aquaporin (AQP)-5 was induced to express AQP5 by the treatment with DNA demethylating agent, decitabine.
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