| Project/Area Number |
23390466
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAMIKAWA Yoshiaki 鹿児島大学, 医学部・歯学部附属病院, 助教 (30332901)
SAKAMOTO Ryoichi 鹿児島大学, 大学院・医歯学総合研究科, 助教 (60452950)
HAMADA Tomofumi 鹿児島大学, 医学部・歯学部附属病院, 助教 (00444894)
KAMIKAWA Yasuko 鹿児島大学, 大学院・医歯学総合研究科, 教務職員 (70253903)
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| Research Collaborator |
KUSUMOTO Takanobu 鹿児島大学, 大学院・医歯学総合研究科
NAGATA Satoshi 鹿児島大学, 大学院・医歯学総合研究科
KANMURA Yuji 鹿児島大学, 大学院・医歯学総合研究科
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
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| Keywords | 口腔癌 / 膜型ムチン / MUC1 / MUC4 / 口腔扁平上皮癌 / 予後規定因子 / 転移 / エピジェネティクス |
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| Research Abstract |
MUC1 and MUC4 mucins are high molecular weight glycoproteins and help to protect and lubricate luminal surfaces under normal physiological conditions. The objective of the current study was to evaluate the prognostic significance of MUC1 and MUC4 expression in patients with oral squamous cell carcinoma (OSCC). Both MUC1 and MUC4 expression were found to be significantly correlated with tumor aggressiveness. In both mucins, the overall survival and disease-free survival rates were significantly worse for patients with expression compared with those without expression. In addition, these expressions were found to be an independent risk factor for subsequent regional lymph node metastasis. Taken together, these results suggest that patients with OSCC showing positive mucin expression should be followed up carefully, and that MUC1/MUC4 immunohistochemistry is a powerful indicator for tumor aggressiveness and can predict subsequent nodal metastasis and outcomes for patients with OSCC.
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