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Analysis of the pathway from periodontal disease to lipid metabolism perturbation

Research Project

Project/Area Number 23390476
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionNiigata University

Principal Investigator

YAMAZAKI Kazuhisa  新潟大学, 医歯学系, 教授 (00182478)

Co-Investigator(Kenkyū-buntansha) TABETA Koichi  新潟大学, 医歯学系, 助教 (20401763)
NAKAJIMA Takako  新潟大学, 医歯学総合病院, 講師 (40303143)
DOMON Hisanori  新潟大学, 医歯学系, 助教 (00594350)
Co-Investigator(Renkei-kenkyūsha) NAKAYAMA Kohji  長崎大学, 医歯(薬)学総合研究科, 教授 (80150473)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords歯周病原細菌 / 歯周炎 / 動脈硬化症 / 脂質代謝 / Pophyromonas gingivalis / 糖代謝 / 炎症 / Porphyromonas gingivalis / 高感度CRP / HDLコレステロール / LDLコレステロール / LXR / ABCA1 / Ido1
Research Abstract

In this study, the effect of infection with periodontopathic bacteria on the lipid metabolism was analyzed. Periodontitis patients demonstrated the shift of serum lipid profile towards atherogenic with concomitant elevation of serum PCSK9 level. In mouse experimental periodontitis model induced by the infection with Porphyromonas gingivalis, various lipid metabolism-related genes including PCSK9 demonstrated changes towards proatherogenic. Serum HDL-cholesterol decreased in P. gingivalis-infected mice. These results suggest that infection with periodontopathic bacteria promotes atherosclerosis by suppression of cholesterol efflux and increased expression of LDL receptor in the liver.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (77 results)

All 2014 2013 2012 2011 Other

All Journal Article (23 results) (of which Peer Reviewed: 23 results,  Open Access: 3 results) Presentation (46 results) (of which Invited: 4 results) Book (5 results) Remarks (3 results)

  • [Journal Article] Age-related alterations in gene expression of gingival fibroblasts stimulated with Porphyromonas gingivalis.2014

    • Author(s)
      Domon H, Tabeta K, Nakajima T, Yamazaki K.
    • Journal Title

      J Periodontal Res.

      Volume: (印刷中) Issue: 4 Pages: 536-543

    • DOI

      10.1111/jre.12134

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Natural killer T cells mediate alveolar bone resorption and a systemic inflammatory response in response to oral infection of mice with Porphyromonas gingivalis.2014

    • Author(s)
      Aoki-Nonaka Y, Nakajima T, Miyauc hi S, Miyazawa H, Yamada H, Dom on H, Tabeta K, Yamazaki K.
    • Journal Title

      J Periodontal Res.

      Volume: VOL.49 Issue: 1 Pages: 69-76

    • DOI

      10.1111/jre.12080

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Th2 cytokines efficiently stimulate periostin production in gingival fibroblasts but periostin does not induce inflammatory response in gingival epithelial cells.2014

    • Author(s)
      Nakajima M, Honda T, Miyauchi S, Yamazaki K.
    • Journal Title

      Archs oral Biol.

      Volume: 59 Issue: 2 Pages: 93-101

    • DOI

      10.1016/j.archoralbio.2013.10.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of distinct T cell subsets in periodontitis - Studies from humans and rodent models.2014

    • Author(s)
      Okui T, Aoki-Nonaka Y, Nakajima T, Yamazaki K.
    • Journal Title

      Cur Oral Health Rep.

      Volume: 1 Issue: 2 Pages: 114-123

    • DOI

      10.1007/s40496-014-0013-z

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sublingual Vaccine with GroEL Attenuates Atherosclerosis.2014

    • Author(s)
      Hagiwara M, Kurita-Ochiai T, Kobayashi R, Hashizume-Takizawa T, Yamazaki K, Yamamoto M.
    • Journal Title

      J Dent Res.

      Volume: 93 Issue: 4 Pages: 382-387

    • DOI

      10.1177/0022034514523784

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum antibodies against Porphyromonas gingivalis GroEL are insufficient to induce P. gingivalis-accelerated atherosclerosis.2013

    • Author(s)
      Hagiwara M, Kurita-Ochiai T, Hashizume-Takizawa T, Suemitsu M, Kuyama K, Yamamoto H, Yamazaki K, Akimoto Y, Yamamoto M
    • Journal Title

      Int J Oral-Med Sci

      Volume: 11 Pages: 291-299

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Deep Intronic Mutation in the Ankyrin-1 Gene Causes Diminished Protein Expression Resulting in Hemolytic Anemia in Mice.2013

    • Author(s)
      Huang H, Zhao P, Arimatsu K, Tabeta K, Yamazaki K, Krieg L, Fu E, Zhang T, Du X.
    • Journal Title

      G3 (Bethesda)

      Volume: 3 Issue: 10 Pages: 1687-1695

    • DOI

      10.1534/g3.113.007013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Porphyromonas gingivalis infection on post-transcriptional regulation of the low-density lipoprotein receptor in mice2012

    • Author(s)
      Miyazawa H, Domon H, et al
    • Journal Title

      Lipids Health Dis.

      Volume: 11 Issue: 1 Pages: 121-121

    • DOI

      10.1186/1476-511x-11-121

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The presence of IL-17^+/FOXP3^+ double-positive cells in periodontitis2012

    • Author(s)
      Okui T, Aoki Y, Ito H, Honda T, Yamazaki K
    • Journal Title

      J Dent Res

      Volume: 91(6) Issue: 6 Pages: 574-579

    • DOI

      10.1177/0022034512446341

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Porphyromonas gingivalis lipopolysaccharide induces miR-146a without altering the production of inflammatory cytokines2012

    • Author(s)
      Honda T, Takahashi N, Miyauchi S, Yamazaki K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 420(4) Pages: 918-925

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between serum antibody titers to Porphyromonas gingivalis and hs-CRP levels as inflammatory markers of periodontitis2012

    • Author(s)
      Miyashita H, Honda T, Maekawa T, Takahashi N, Aoki Y, Nakajima T, Tabeta K, Yamazaki K
    • Journal Title

      Archs oral Biol

      Volume: 57(6) Pages: 820-829

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oral infection with Porphyromonas gingivalis and systemic cytokine profile in C57BL/6.KOR -ApoE^<shl> mice2012

    • Author(s)
      Miyauchi S, Maekawa T, Aoki Y, Miyazawa H, Tabeta K, Nakajima T, Yamazaki K
    • Journal Title

      J Periodont. Res

      Volume: 47(3) Pages: 402-408

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased serum PCSK9 levels are associated with periodontal infection but do not correlate with LDL cholesterol level2012

    • Author(s)
      Miyazawa H, Honda T, Miyauchi S, Domon H, Okui T, Nakajima T, Tabeta K, Yamazaki K
    • Journal Title

      Clin Chim Acta

      Volume: 413 Pages: 154-159

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration2012

    • Author(s)
      宮沢、土門, ら
    • Journal Title

      Clin Chim Acta

      Volume: 413 Issue: 1-2 Pages: 154-159

    • DOI

      10.1016/j.cca.2011.09.023

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral infection with Porphyromonas gingivalis and systemic cytokine profile in C57BL/6. KOR-ApoE(shl) mice2012

    • Author(s)
      Miyauchi S, Tabeta K, Nakajima T, Yamazaki K, 他3名
    • Journal Title

      J Periodontal Res

      Volume: 47(3) Issue: 3 Pages: 402-408

    • DOI

      10.1111/j.1600-0765.2011.01441.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between serum antibody titres to Porphyromonas gingivalis and hs-CRP levels as inflammatory markers of periodontitis2012

    • Author(s)
      Miyashita H., et. al.
    • Journal Title

      Arch Oral Biol

      Volume: (in press) Issue: 6 Pages: 820-829

    • DOI

      10.1016/j.archoralbio.2011.11.008

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated Antibody Titers to Porphyromonas gingivalis as a Possible Predictor of Ischemic Vascular Disease2011

    • Author(s)
      Tabeta K, Nakajima T, Yamazaki K, 他6名
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 18 Issue: 9 Pages: 808-817

    • DOI

      10.5551/jat.6957

    • NAID

      130004845393

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile2011

    • Author(s)
      Maekawa T, Tabeta K, Nakajima T, Yamazaki K, 他5名
    • Journal Title

      PLoS One

      Volume: 6(5) Issue: 5 Pages: e20240-e20240

    • DOI

      10.1371/journal.pone.0020240

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periodontitis as a risk factor for atherosclerosis2011

    • Author(s)
      Yamazaki K, Tabeta K and Nakajima T
    • Journal Title

      J Oral Biosci

      Volume: 53(3) Issue: 3 Pages: 221-232

    • DOI

      10.1016/s1349-0079(11)80005-8

    • NAID

      10029494888

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased expressions of C-reactive protein gene in inflamed gingival tissues could be derived from endothelial cells stimulated with interleukin-62011

    • Author(s)
      Maekawa T, Tabeta K, Kajita-Okui K, Takahashi N, Honda T, Nakajima T and Yamazaki K
    • Journal Title

      Arch Oral Biol

      Volume: 56(11) Pages: 1312-1318

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of C-reactive protein gene in inflamed gingival tissues could be derived from endothelial cells stimulated with interleukin-62011

    • Author(s)
      Maekawa T., et al.
    • Journal Title

      Arch Oral Biol

      Volume: 56(11) Issue: 11 Pages: 1312-1318

    • DOI

      10.1016/j.archoralbio.2011.04.010

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periodontitis as a risk factor for atherosclerosis2011

    • Author(s)
      Yamazaki K, et al.
    • Journal Title

      J Oral Biosci

      Volume: 53 Pages: 221-232

    • NAID

      10029494888

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated antibody titers to Porphyromonas gingivalis as a possible predictor of ischemic vascular disease-results from the Tokamachi-Nakasato cohort study2011

    • Author(s)
      Tabeta K, et al.
    • Journal Title

      J Atheroscler Thromb

      Volume: 18 Pages: 808-817

    • NAID

      130004845393

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Periodontitis and Systemic Disease -New Insights into the Mechanisms2014

    • Author(s)
      Yamazaki, K
    • Organizer
      Kyudai Oral Bioscience 2014 -8th International Symposium-
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2014-03-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Porphyromonas gingivalis 感染はNKT細胞のサイトカイン産生を誘導する2013

    • Author(s)
      山田ひとみ, 宮沢春菜, 奥井隆文, 多部田康一, 中島貴子, 山崎和久
    • Organizer
      第138回日本歯科保存学会2013年度春季学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2013-06-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Porphyromonas gingivalis 口腔感染マウスモデルにおいて小胞体ストレスは破骨細胞形成に関与し, 歯槽骨吸収を誘導する2013

    • Author(s)
      土門久哲, 山田ひとみ, 宮内小百合, 宮沢春菜, 中島貴子, 多部田康一, 山崎和久
    • Organizer
      第138回日本歯科保存学会2013年度春季学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2013-06-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯周病と心血管病変リスクの関連2013

    • Author(s)
      山崎和久
    • Organizer
      ワークショップ「口腔内炎症性疾患と全身の関連」第102回日本病理学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2013-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Porphyromonas gingivalis 口腔感染マウスモデルで誘導されるインスリン抵抗性は脂肪組織および肝臓における炎症反応と関連する2013

    • Author(s)
      有松 圭, 土門久哲, 山田ひとみ, 宮内小百合, 宮沢春菜, 皆川高嘉, 中島麻由佳, 中島貴子, 多部田康一, 山崎和久
    • Organizer
      第56回春季日本歯周病学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2013-06-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Porphyromonas gingivalis 口腔感染はマウス腸内細菌叢を変動させインスリン抵抗性を誘導する2013

    • Author(s)
      山崎和久, 有松 圭, 土門久哲, 山田ひとみ, 宮内小百合, 宮沢春菜, 皆川高嘉, 中島麻由佳, 中島貴子, 多部田康一
    • Organizer
      第56回春季日本歯周病学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2013-06-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Periodontal Disease and Atherothrombotic Disease; Lessons from Clinical and Basic Studies2013

    • Author(s)
      Yamazaki, K
    • Organizer
      The Forsyth Institute Seminar Series
    • Place of Presentation
      Boston, USA
    • Year and Date
      2013-01-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Chronic stimulation with Porphyromonas gigivalis induced IL-4-producing NKT cells2013

    • Author(s)
      Yamada H, Yamazaki K, et al
    • Organizer
      91st General Session & Exhibition of the IADR
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Porphyromonas gingivalis infection affects the posttranscriptional regulation of LDL receptor2012

    • Author(s)
      Miyazawa H, Tabeta K, Miyauchi S, Aoki-Nonaka Y, Domon H, Honda T, Nakajima T, Yamazaki K
    • Organizer
      第60回国際歯科研究学会日本部会(JADR)総会・学術大会
    • Place of Presentation
      新潟市
    • Year and Date
      2012-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯周疾患と動脈硬化性疾患の関わり-さらなるエビデンス蓄積の必要性-2012

    • Author(s)
      山崎和久
    • Organizer
      <シンポジウム>歯周病と全身の関わり. 日本歯科保存学会2012年度秋季学術大会(第137回)
    • Place of Presentation
      広島市
    • Year and Date
      2012-11-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Periodontal Disease and Atherothrombotic Disease; Lessons from Clinical and Basic Sciences2012

    • Author(s)
      Yamazaki, K
    • Organizer
      Special Lecture
    • Place of Presentation
      Khon Kaen University School of Dentistry. Thailand
    • Year and Date
      2012-07-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Porphyromonas gingivalis感染マウスモデルにおいてPCSK9 産生が上昇し脂質プロファイルが変動する2012

    • Author(s)
      宮沢春菜, 本田朋之, 宮内小百合, 土門久哲, 奥井隆文, 中島貴子, 多部田康一, 山崎和久
    • Organizer
      第55回春季日本歯周病学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2012-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Porphyromonas gingivalis 口腔感染による全身応答. -血清中サイトカインプロファイルの変化-2012

    • Author(s)
      宮内小百合, 前川知樹, 青木由香莉, 宮沢春菜, 多部田康一, 中島貴子, 山崎和久
    • Organizer
      第45回新潟歯学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2012-04-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Keynote Lecture "Periodontal Disease and Atherothrombotic Disease; Lessons from Clinical and Basic Sciences"2012

    • Author(s)
      Yamazaki, K
    • Organizer
      Special Lecture. QOL International Symposium
    • Place of Presentation
      Niigata
    • Year and Date
      2012-02-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Periodontal Disease and Atherothrombotic Disease; Lessons from Clinical and Basic Studies2012

    • Author(s)
      Yamazaki, K
    • Organizer
      The 7th Global COE International Symposium
    • Place of Presentation
      Tokyo Medical and Dental University, Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] Periodontal Disease and Atherothrombotic Disease; Lessons from Clinical and Basic Sciences2012

    • Author(s)
      Yamazaki, K
    • Organizer
      First International Conference on Porphyromonas gingivalis and Related Bacterial Species
    • Place of Presentation
      Ngasaki, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Periodontal Disease and Atherothrombotic Disease; Lessons from Clinical and Basic Studies.2012

    • Author(s)
      Kazuhisa Yamazaki
    • Organizer
      The 7th Global COE International Symposium. Tokyo Medical and Dental University
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Periodontal Disease and Atherothrombotic Disease; Lessons from Clinical and Basic Sciences. Special Lecture2011

    • Author(s)
      Yamazaki, K
    • Organizer
      30th Annual Academic Session of Korean Division of International Association for Dental Research
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-11-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Periodontal disease and atherothrombotic disease ; Lessons from Clinical and Basic Sciences. Special Lecture2011

    • Author(s)
      Yamazaki K
    • Organizer
      30th Annual Academic Session of Korean Division of International Association for Dental Research
    • Place of Presentation
      Seoul, Korea(招待講演)
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Porphyromonas gingivalis LPS がmicroRNA 発現に及ぼす影響2011

    • Author(s)
      本田朋之, 高橋直紀, 宮内小百合, 奥井隆文, 多部田康一, 中島貴子, 山崎和久
    • Organizer
      第135回日本歯科保存学会2011年度秋季学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Porphyromonas gingivalis 感染マウスモデルにおける炎症応答へのNKT 細胞の関与2011

    • Author(s)
      青木由香莉, 宮下博考, 宮内小百合, 宮沢春菜, 中島貴子, 高橋直紀, 前川知樹, 多部田康一, 山崎和久
    • Organizer
      第135回日本歯科保存学会2011年度秋季学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-20
    • Related Report
      2013 Final Research Report
  • [Presentation] NKT cells promote the inflammatory responses in P. gingivalis-infected mice2011

    • Author(s)
      Aoki Y, Nakajima T, Takahashi N, Maekawa T, Miyashita H, Miyauchi S, Miayazawa H, Tabeta K, and Yamazaki K
    • Organizer
      59回国際歯科研究学会日本部会(JADR)総会・学術大会
    • Place of Presentation
      広島市
    • Year and Date
      2011-10-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Porphyromonas gingivalis 口腔感染による脂質代謝関連遺伝子の変動2011

    • Author(s)
      宮内小百合, 前川知樹, 高橋直紀, 多部田康一, 青木由香莉, 宮下博考, 宮沢春菜, 中島貴子, 山崎和久
    • Organizer
      第54回秋季日本歯周病学会学術大会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯周病と動脈硬化-患者データは因果関係を示すか-2011

    • Author(s)
      山崎和久
    • Organizer
      <シンポジウム>ペリオドンタルメディシン研究の現状と展望 -日本人におけるエビデンス- 第54回日本歯周病学会学術大会
    • Place of Presentation
      下関市
    • Year and Date
      2011-09-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯周病と動脈硬化-患者データは因果関係を示すか-(シンポジウム)ペリオドンタルメディシン研究の現状と展望-日本人におけるエビデンス-2011

    • Author(s)
      山崎和久
    • Organizer
      第54回秋季日本歯周病学会学術大会
    • Place of Presentation
      山口県下関市(招待講演)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Porphyromonas gingivalis口腔感染による脂質代謝関連遺伝子の変動2011

    • Author(s)
      宮内小百合, ら
    • Organizer
      第54回秋季日本歯周病学会学術大会
    • Place of Presentation
      山口県下関市
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歯周炎罹患がPCSK9および脂質プロファイルに及ぼす影響2011

    • Author(s)
      宮沢春菜, ら
    • Organizer
      第54回秋季日本歯周病学会学術大会
    • Place of Presentation
      山口県下関市
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile2011

    • Author(s)
      Tabeta, T. Yamazaki, K
    • Organizer
      Gordon Research Conference on Periodontal Diseases
    • Place of Presentation
      Davidson College, USA
    • Year and Date
      2011-07-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile2011

    • Author(s)
      Tabeta K, et al.
    • Organizer
      The 2011 Gordon Research Conference on "Periodontal Diseases"
    • Place of Presentation
      Shallotte, NC, USA
    • Year and Date
      2011-07-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歯周疾患と心血管系疾患2011

    • Author(s)
      山崎和久
    • Organizer
      第9回補完医療を考える会
    • Place of Presentation
      大阪市大阪大学中之島センター
    • Year and Date
      2011-02-18
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト歯肉上皮細胞におけるinterleukin (IL)-17とIL-17受容体の発現プロファイル.

    • Author(s)
      宮内小百合、本田朋之、奥井隆文、中島貴子、多部田康一、山崎和久.
    • Organizer
      第56回春季日本歯周病学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Porphyromonas gingivalis口腔感染はマウス腸内細菌叢を変動させインスリン抵抗性を誘導する.

    • Author(s)
      山崎和久、有松 圭、土門久哲、山田ひとみ、宮内小百合、宮沢春菜、皆川高嘉、中島麻由佳、中島貴子、多部田康一
    • Organizer
      第56回春季日本歯周病学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Porphyromonas gingivalis口腔感染マウスモデルで誘導されるインスリン抵抗性は脂肪組織および肝臓における炎症反応と関連する.

    • Author(s)
      有松 圭、土門久哲、山田ひとみ、宮内小百合、宮沢春菜、皆川高嘉、中島麻由佳、中島貴子、多部田康一、山崎和久.
    • Organizer
      第56回春季日本歯周病学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯周病と心血管病変リスクの関連.

    • Author(s)
      山崎和久
    • Organizer
      日本病理学会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Porphyromonas gingivalis感染はNKT細胞のサイトカイン産生を誘導する.

    • Author(s)
      山田ひとみ、宮沢春菜、奥井隆文、多部田康一、中島貴子、山崎和久.
    • Organizer
      第138回日本歯科保存学会2013年度春季学術大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] Porphyromonas gingivalis口腔感染マウスモデルにおいて小胞体ストレスは破骨細胞形成に関与し、歯槽骨吸収を誘導する.

    • Author(s)
      土門久哲、山田ひとみ、宮内小百合、宮沢春菜、中島貴子、多部田康一、山崎和久.
    • Organizer
      第138回日本歯科保存学会2013年度春季学術大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] Resveratrolがヒト歯肉上皮細胞の炎症性応答に及ぼす影響.

    • Author(s)
      皆川高嘉、奥井隆文、多部田康一、中島貴子、村上伸也、山崎和久.
    • Organizer
      第138回日本歯科保存学会2013年度春季学術大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] Resveratrolは歯肉上皮細胞の炎症性応答を抑制する.

    • Author(s)
      奥井隆文、皆川高嘉、多部田康一、中島貴子、村上伸也、山崎和久.
    • Organizer
      第56回秋季日本歯周病学会学術大会
    • Place of Presentation
      前橋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯肉上皮細胞における新規イオンチャネルの発現解析およびその機能の検討.

    • Author(s)
      高橋直紀、松田由実、多部田康一、山崎和久.
    • Organizer
      第56回秋季日本歯周病学会学術大会
    • Place of Presentation
      前橋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯周病安定期治療中の活動性歯周ポケットに対する経口抗菌療法の細菌学的効果(第2報).

    • Author(s)
      中島貴子,伊藤春江、奥井隆文、中島麻由佳、宮下博考,多部田康一、山崎和久.
    • Organizer
      第56回秋季日本歯周病学会学術大会
    • Place of Presentation
      前橋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯周ポケットからの臨床分離株に対する抗菌薬の有効性、耐性の検討.

    • Author(s)
      中島貴子,伊藤春江、奥井隆文、多部田康一、中島麻由佳、山崎和久.
    • Organizer
      第139回日本歯科保存学会2013年度秋季学術大会
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯周炎病態形成におけるPeriostinの役割.

    • Author(s)
      中島麻由佳、宮内小百合、本田朋之、村上伸也、山崎和久.
    • Organizer
      第139回日本歯科保存学会2013年度秋季学術大会
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report
  • [Presentation] Porphyromonas gingivalis感染マウスモデルにおいてPCSK9産生が上昇し脂質プロファイルが変動する.

    • Author(s)
      宮沢春菜
    • Organizer
      第55回春季日本歯周病学会学術大会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] Periodontal Disease and Atherothrombotic Disease; Lessons from Clinical and Basic Sciences.

    • Author(s)
      Kazuhisa Yamazaki
    • Organizer
      First International Conference on Porphyromonas gingivalis and Related Bacterial Species.
    • Place of Presentation
      長崎
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 歯周疾患と動脈硬化性疾患の関わり-さらなるエビデンス蓄積の必要性-.

    • Author(s)
      山崎和久
    • Organizer
      日本歯科保存学会2012年度秋季学術大会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Porphyromonas gingivalis infection affects the posttranscriptional regulation of LDL receptor

    • Author(s)
      Haruna Miayazawa
    • Organizer
      第60回国際歯科研究学会日本部会(JADR)総会・学術大会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Book] ザ・ペリオドントロジー第2版(和泉雄一・木下淳博・沼部幸博・山本松男編著)第1章歯周疾患を正しく理解するための基礎知識 6. 歯周疾患の免疫学2014

    • Author(s)
      山崎和久・多部田康一
    • Publisher
      永末書店
    • Related Report
      2013 Final Research Report
  • [Book] 臨床歯周病学第2版(吉江弘正, 伊藤公一, 村上伸也, 申基喆 編著). 2 編ベーシック編 第13章 歯周組織の病理変化2013

    • Author(s)
      山崎和久, 中島貴子
    • Publisher
      医歯薬出版
    • Related Report
      2013 Final Research Report
  • [Book] イラストで語る歯科医学最前線(吉江弘正 監修). 6. 歯周疾患が及ぼす冠動脈性心疾患のリスク2013

    • Author(s)
      山崎和久
    • Publisher
      クインテッセンス出版株式会社
    • Related Report
      2013 Final Research Report
  • [Book] 5 疾病の口腔ケア(藤本篤士, 武井典子, 片倉 朗, 大野友久, 糸田昌隆, 杉山 勝, 吉江弘正, 小林芳友 編著). 急性心筋梗塞と口腔2013

    • Author(s)
      山崎和久, 中島貴子
    • Publisher
      医歯薬出版
    • Related Report
      2013 Final Research Report
  • [Book] ビジュアル歯周病を科学する (天野敦雄・岡賢二・村上伸也 編著) CHAPTER 4 歯周病病因論・宿主因子 1. 宿主免疫と歯周組織破壊2012

    • Author(s)
      山崎和久, 多部田康一, 中島貴子
    • Publisher
      クインテッセンス出版株式会社
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.dent.niigata-u.ac.jp/yamazaki_labo/

    • Related Report
      2013 Final Research Report
  • [Remarks] 歯周-全身プロジェクト 山崎研究室

    • URL

      http://www.dent.niigata-u.ac.jp/yamazaki_labo/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.dent.niigata-u.ac.jp/yamazak_labo/

    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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