Analysis of the pathway from periodontal disease to lipid metabolism perturbation
| Project/Area Number |
23390476
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TABETA Koichi 新潟大学, 医歯学系, 助教 (20401763)
NAKAJIMA Takako 新潟大学, 医歯学総合病院, 講師 (40303143)
DOMON Hisanori 新潟大学, 医歯学系, 助教 (00594350)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAYAMA Kohji 長崎大学, 医歯(薬)学総合研究科, 教授 (80150473)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 歯周病原細菌 / 歯周炎 / 動脈硬化症 / 脂質代謝 / Pophyromonas gingivalis / 糖代謝 / 炎症 / Porphyromonas gingivalis / 高感度CRP / HDLコレステロール / LDLコレステロール / LXR / ABCA1 / Ido1 |
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| Research Abstract |
In this study, the effect of infection with periodontopathic bacteria on the lipid metabolism was analyzed. Periodontitis patients demonstrated the shift of serum lipid profile towards atherogenic with concomitant elevation of serum PCSK9 level. In mouse experimental periodontitis model induced by the infection with Porphyromonas gingivalis, various lipid metabolism-related genes including PCSK9 demonstrated changes towards proatherogenic. Serum HDL-cholesterol decreased in P. gingivalis-infected mice. These results suggest that infection with periodontopathic bacteria promotes atherosclerosis by suppression of cholesterol efflux and increased expression of LDL receptor in the liver.
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Report
(4 results)
Research Products
(76 results)
