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Periodontal disease susceptibility evaluated on membrane traffic machinery

Research Project

Project/Area Number 23390477
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionOsaka University

Principal Investigator

AMANO Atsuo  大阪大学, 歯学研究科(研究院), 教授 (50193024)

Co-Investigator(Kenkyū-buntansha) KUBONIWA Masae  大阪大学, 歯学部附属病院, 講師 (00303983)
FURUTA Nobumichi  大阪大学, 大学院・歯学研究科, 助教 (50452446)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords歯学 / 歯周病菌 / 歯周病 / 細菌・組織 / メンブレントラフィック / 細胞内侵入 / オートファジー / 細菌感染 / 細胞・組織 / SNARE
Research Abstract

Gingival epithelial cells function as innate host defense barriers to prevent intrusion by periodontal bacteria. Nevertheless, Porphyromonas gingivalis can enter these cells and pass through the epithelial barrier into deeper tissues. In this study, P. gingivalis induced cellular invagination to internalize the pathogen. The bacteria were sorted to early endosomes, and the half of them were transported to recycling pathway via SNARE protein VAMP2, which allowed the bacterial exit to the extracellular circumstances, a mechanism of cell-to-cell spread within periodontal tissues. The intracellular pathogens impaired fundamental cellular functions within the cargo. While, remaining half were sorted to lytic compartments, including autophagosomes. The machinery was found to be formed in contact sites between endoplasmic reticulum and mitochondria, which is a very unique finding indicating that 2 different organelle make a concerted effort to the formation of another organelle.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (120 results)

All 2014 2013 2012 2011 Other

All Journal Article (56 results) (of which Peer Reviewed: 43 results,  Open Access: 1 results) Presentation (49 results) (of which Invited: 26 results) Book (11 results) Remarks (4 results)

  • [Journal Article] Porphyromonas gingivalis promotes invasion of oral squamous cell carcinoma through induction of proMMP9 and its activation2014

    • Author(s)
      Inaba H, Sugita H, Kuboniwa M, Iwai S, Hamada M, Noda T, Morisaki I, Lamont RJ, Amano A
    • Journal Title

      Cellular Microbiology

      Volume: 16(1) Issue: 1 Pages: 131-145

    • DOI

      10.1111/cmi.12211

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcellular offensive weapons of Porphyromonas gingivalis in host-parasite interactions2014

    • Author(s)
      Amano A, Kuboniwa M, Takeuchi H
    • Journal Title

      Journal of Oral Bioscience

      Volume: 56(3)(in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Genetic characteristics and pathogenic mechanisms of periodontal pathogens2014

    • Author(s)
      Amano A, Chen C, Honma K, Li C, Settem RP, Sharma A
    • Journal Title

      Advances in Dental Research

      Volume: 26(1) Issue: 1 Pages: 15-22

    • DOI

      10.1177/0022034514526237

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcellular offensive weapons of Porphyromonas gingivalis in host-parasite interactions2014

    • Author(s)
      Amano A, Kuboniwa M, Takeuchi H
    • Journal Title

      J Oral Biosci

      Volume: 56

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular identification and antibiotic-resistant bacteria isolated from primary dentition infections2014

    • Author(s)
      Loyola-Rodriguez JP, Garcia-Cortes JO, Martinez-Martinez RE, Patiño-Marin N, Martinez-Castañon GA, Zavala-Alonso NV, Amano A
    • Journal Title

      Aust Dent J

      Volume: 59

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erythritol alters microstructures and metabolomic profiles of biofilm composed of Streptococcus gordonii and Porphyromonas gingivalis2013

    • Author(s)
      Hashino E, Kuboniwa M, Alghamdi S, Yamaguchi M, Yamamoto R, Cho H, Amano A
    • Journal Title

      Molecular Oral Microbiology

      Volume: 28(6) Issue: 6 Pages: 435-451

    • DOI

      10.1111/omi.12037

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression pattern of zinc-finger transcription factor Odd-skipped related 2 in murine development and neonatal stage2013

    • Author(s)
      Kawai S, Michikami I, Kitagaki J, Hashino E, Amano A
    • Journal Title

      Gene Expression Patterns

      Volume: 13(8) Issue: 8 Pages: 372-376

    • DOI

      10.1016/j.gep.2013.06.007

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genotype analysis of Porphyromonas gingivalis fimA in Korean adults using new primers2013

    • Author(s)
      Moon J-H, Herr Y, Lee H-W, Shin S-I, Kim C, Amano A, Lee J-Y
    • Journal Title

      Journal of Medical Microbiology

      Volume: 62 Pages: 1290-1294

    • Related Report
      2013 Final Research Report
  • [Journal Article] Autophagosome forms at the ER-mitochondria contact sites2013

    • Author(s)
      Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Ohmori H, Noda T, Haraguchi T, Hiraoka Y, Amano A, Yoshimori T
    • Journal Title

      Nature

      Volume: 495(7441) Pages: 389-393

    • Related Report
      2013 Final Research Report
  • [Journal Article] The serine phosphatase SerB of Porphyromonas gingivalis suppresses IL-8 production by dephosphorylation of NF-κB RelA/p652013

    • Author(s)
      Takeuchi H, Hirano T, Whitmore SE, Morisaki I, Amano A, Lamont RJ
    • Journal Title

      PLoS Pathogens

      Volume: 9(4) Issue: 4 Pages: 1-13

    • DOI

      10.1371/journal.ppat.1003326

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of Porphyromonas gingivalis client proteins that bind to Streptococcus oralis Glyceraldehyde-3-Phosphate Dehydrogenase2013

    • Author(s)
      Maeda K, Nagata H, Kuboniwa M, Ojima M, Osaki T, Minamino N, Amano A
    • Journal Title

      Infection and Immunity

      Volume: 81(3) Issue: 3 Pages: 753-763

    • DOI

      10.1128/iai.00875-12

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Porphyromonas gingivalis fimbriae2013

    • Author(s)
      Enersen M, Nakano K, Amano A
    • Journal Title

      Journal of Oral Microbiology

      Volume: 5 Issue: 1 Pages: 10-10

    • DOI

      10.3402/jom.v5i0.20265

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of periodontal biofilm in Down syndrome patients: a comparative study2013

    • Author(s)
      Martinez-Martinez RE, Loyola-Rodriguez JP*, Bonilla-Garro SE, Patiño-Marin N, Haubek D, Amano A, Poulsen K
    • Journal Title

      J Clin Pediatr Dent

      Volume: 37 Pages: 289-295

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CRISPR regulation of intraspecies diversification by limiting IS transposition and intercellular recombination2013

    • Author(s)
      Watanabe T, Nozawa T, Aikawa C, Amano A, Maruyama F, Na kagawa I.
    • Journal Title

      Genome Biology and Evolution

      Volume: 5 Issue: 6 Pages: 1099-1114

    • DOI

      10.1093/gbe/evt075

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Porphyromonas gingivalis fimbriae2013

    • Author(s)
      Enersen M
    • Journal Title

      Journal of Oral Microbiology

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of NF-κB RelA/p65 is a target for Porphyromonas gingivalis SerB-mediated IL-8 suppression2013

    • Author(s)
      Takeuchi H
    • Journal Title

      PLoS Pathogens

      Volume: 9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of periodontal biofilm in Down syndrome patients: a comparative study2013

    • Author(s)
      Martinez-Martinez RE
    • Journal Title

      Journal of Medical Microbiology

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagosomes form at ER.mitochondria contact sites2013

    • Author(s)
      Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Oomori H, Noda T, Haraguchi T, Hiraoka Y, Amano A, Yoshimori T
    • Journal Title

      Nature

      Volume: 495 Issue: 7441 Pages: 389-93

    • DOI

      10.1038/nature11910

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genotype analysis of Porphyromonas gingivalis fimA in Korean adults using new primers2013

    • Author(s)
      Moon JH
    • Journal Title

      Journal of Medical Microbiology

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transition metal ions induce carnosinase activity in PepD-homologous protein from Porphyromonas gingivalis.2012

    • Author(s)
      Aoki A, Shibata Y, Okano S, Maruyama F, Amano A, Nakagawa I, Abiko Y
    • Journal Title

      Microb Pathog.

      Volume: Vol52 Issue: 1 Pages: 17-24

    • DOI

      10.1016/j.micpath.2011.09.003

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development and evaluation of new primers for PCR-based identification of type II fimA of Porphyromonas gingivalis2012

    • Author(s)
      Moon JH, Shin SI, Chung JH, Lee SW, Amano A, Lee JY
    • Journal Title

      FEMS Immunology & Medical Microbiology

      Volume: 64(3) Issue: 9 Pages: 425-428

    • DOI

      10.1099/jmm.0.054247-0

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease2012

    • Author(s)
      Yoneda M, Naka S, Nakano K, Wada K, Endo H, Mawatari H, Imajo K, Nomura R, Hokamura K, Ono M, Murata S, Tohnai I, Sumida Y, Shima T, Kuboniwa M, Umemura K, Kamisaki Y, Amano A, Okanoue T, Ooshima T, Nakajima A.
    • Journal Title

      BMC Gastroenterol

      Volume: 12 Issue: 1 Pages: 12-16

    • DOI

      10.1186/1471-230x-12-16

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex2012

    • Author(s)
      Kawai S, Amano A
    • Journal Title

      Journal of Cell Biology

      Volume: 197(2) Issue: 2 Pages: 201-208

    • DOI

      10.1083/jcb.201110008

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative regulation of Odd-skipped related 2 by TGF-achieves the induction of cellular migration and the arrest of cell cycle2012

    • Author(s)
      Kawai S, Amano A
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 421(4) Issue: 4 Pages: 696-700

    • DOI

      10.1016/j.bbrc.2012.04.064

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of signaling pathways mediating cell cycle arrest and apoptosis induced by Porphyromonas gingivalis in human trophoblasts2012

    • Author(s)
      Inaba H, Kuboniwa M, Sugita H, Lamont RJ, Amano A
    • Journal Title

      Infection and Immunity

      Volume: 80(8) Issue: 8 Pages: 2847-2857

    • DOI

      10.1128/iai.00258-12

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution and molecular characterization of Porphyromonas gulae carrying a new fimA genotype2012

    • Author(s)
      Yamasaki Y, Nomura R, Nakano K, Inaba H, Kuboniwa M, Hirai N, Shirai M, Kato Y, Murakami M, Naka S, Iwai S, Matsumoto-Nakano M, Ooshima T, Amano A, Asai F
    • Journal Title

      Veterinary Microbiology

      Volume: 161(1) Issue: 1-2 Pages: 196-205

    • DOI

      10.1016/j.vetmic.2012.07.026

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insights into the virulence of oral biofilms : discoveries from proteomics2012

    • Author(s)
      Kuboniwa M, Tribble GD, Hendrickson EL, Amano A, Lamont RJ, Hackett M
    • Journal Title

      Expert Review of Proteomics

      Volume: 9(3) Issue: 3 Pages: 311-323

    • DOI

      10.1586/epr.12.16

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SNARE mediates autophagosome-lysosome fusion2012

    • Author(s)
      Furuta N, Amano A
    • Journal Title

      Journal of Oral Bioscience

      Volume: 54(2) Pages: 83-85

    • Related Report
      2013 Final Research Report
  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy2012

    • Author(s)
      Klionsky DJ, Amano A, and 1268 others
    • Journal Title

      Autophagy

      Volume: 8(4) Pages: 1-100

    • Related Report
      2013 Final Research Report
  • [Journal Article] Cell entry and exit by periodontal pathogen Porphyromonas gingivalis2012

    • Author(s)
      Amano A, Furuta N
    • Journal Title

      Journal of Oral Bioscience

      Volume: 54(1) Pages: 54-57

    • Related Report
      2013 Final Research Report
  • [Journal Article] Cardiovascular diseases and periodontal diseases2012

    • Author(s)
      Amano A
    • Journal Title

      Clinical Calcium

      Volume: 22 Pages: 43-48

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Development and evaluation of new primers for PCR-based identification of type II fimA of Porphyromonas gingivalis2012

    • Author(s)
      Moon JH, et al
    • Journal Title

      FEMS Immunology & Medical Microbiology

      Volume: Nov 3(In press) Issue: 3 Pages: 425-428

    • DOI

      10.1111/j.1574-695x.2011.00889.x

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy2012

    • Author(s)
      Klionsky DJ
    • Journal Title

      Autophagy

      Volume: 8 Pages: 445-544

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SNARE mediates autophagosome-lysosome fusion2012

    • Author(s)
      Furuta N
    • Journal Title

      Journal of Oral Bioscience

      Volume: 54 Pages: 83-85

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell entry and exit by periodontal pathogen Porphyromonas gingivalis2012

    • Author(s)
      Amano A
    • Journal Title

      Journal of Oral Bioscience

      Volume: 54 Pages: 54-57

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transition metal ions induce carnosinase activity in PepD-homologous protein from Porphyromonas gingivalis2012

    • Author(s)
      Aoki A, et al
    • Journal Title

      Microbial Pathogenesis

      Volume: 52 Pages: 17-24

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease2012

    • Author(s)
      Yoneda M, et al
    • Journal Title

      BMC Gastroenterology

      Volume: 12 Pages: 16-16

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex2012

    • Author(s)
      Kawai S, et al
    • Journal Title

      Journal of Cell Biology

      Volume: 192 Pages: 201-208

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insights into the pathogenesis of dental plaque : discoveries from proteomics2012

    • Author(s)
      Kuboniwa M, et al
    • Journal Title

      Expert Review

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 循環器疾患と歯周病2012

    • Author(s)
      天野敦雄, 他
    • Journal Title

      CLINICAL CALCIUM

      Volume: 22 Pages: 43-48

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 病因論から再考する歯周治療2012

    • Author(s)
      天野敦雄
    • Journal Title

      障害者歯科

      Volume: 32 Pages: 1-7

    • NAID

      10030299367

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Proliferation of smooth muscle cells stimulated with Porphyromonas gingivalis is inhibited by apple polyphenol2011

    • Author(s)
      Inaba H, Tagashira M, Kanda T, Amano A
    • Journal Title

      Journal of Periodontology

      Volume: 82(11) Issue: 11 Pages: 1616-1622

    • DOI

      10.1902/jop.2011.100785

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The collagen-binding protein of Streptococcus mutans is involved in hemorrhagic stroke2011

    • Author(s)
      Nakano K, Hokamura K, Taniguchi N, Wada K, Kudo C, Nomura R, Kojima A, Naka S, Muranaka Y, Thura M, Nakajima A, Masuda K, Nakagawa I, Speziale P, Shimada N, Amano A, Kamisaki Y, Tanaka T, Umemura K, Ooshima T.
    • Journal Title

      Nature Communications

      Volume: 2 Issue: 1 Pages: 485-485

    • DOI

      10.1038/ncomms1491

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exit of intracellular Porphyromonas gingivalis from gingival epithelial cells is mediated by endocytic recycling pathway2011

    • Author(s)
      Takeuchi H, et al
    • Journal Title

      Cellular Microbiology

      Volume: 13 Issue: 5 Pages: 677-691

    • DOI

      10.1111/j.1462-5822.2010.01564.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cellular ATP synthesis mediated by type III sodium-dependent phosphate transporter Pit-1 is critical to chondrogenesis2011

    • Author(s)
      Sugita A, Kawai S, Hayashibara T, Amano A, Ooshima T, Michigami T, Yoshikawa H, Yoneda T
    • Journal Title

      Journal of Biological Chemistry

      Volume: 286(4) Issue: 4 Pages: 3094-3103

    • DOI

      10.1074/jbc.m110.148403

    • Related Report
      2013 Final Research Report
  • [Journal Article] Characterization of aortic aneurysms in cardiovascular disease patients harboring Porphyromonas gingivalis2011

    • Author(s)
      Nakano K, Wada K, Nomura R, Nemoto H, Inaba H, Kojima A, Naka S, Hokamura K, Mukai T, Nakajima A, Umemura K, Kamisaki Y, Yoshioka H, Taniguchi K, Amano A, Ooshima T
    • Journal Title

      Oral Diseases

      Volume: 17(4) Issue: 4 Pages: 370-378

    • DOI

      10.1111/j.1601-0825.2010.01759.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell entry and exit by periodontal pathogen via recycling pathway2011

    • Author(s)
      Takeuchi H, Furuta N, AmanoA
    • Journal Title

      Communicative & Integrative Biology

      Volume: 4(5) Pages: 587-589

    • Related Report
      2013 Final Research Report
  • [Journal Article] Characterization of aortic aneurysms in cardiovascular disease patients harboring Porphyromonas gingivalis2011

    • Author(s)
      Nakano K, et al
    • Journal Title

      Oral Diseases

      Volume: 17 Pages: 370-378

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular ATP synthesis mediated by type III sodium-dependent phosphate transporter Pit-1 is critical to chondrogenesis2011

    • Author(s)
      Sugita A, et al
    • Journal Title

      Journal of Biological Chemistry

      Volume: 286 Pages: 3094-3103

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exit of intracellular Porphyromonas gingivalis from gingival epithelial cells is mediated by endocytic recycling pathway2011

    • Author(s)
      Takeuchi H, et al
    • Journal Title

      Cellular Microbiology

      Volume: 13 Pages: 677-691

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The collagen-binding protein of Streptococcus mutans is involved in hemorrhagic stroke2011

    • Author(s)
      Nakano K, et al
    • Journal Title

      Nature Communications

      Volume: 2 Pages: 485-485

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Consideration on English education at Osaka University Graduate School of Dentistry2011

    • Author(s)
      Hamazaki Y, et al
    • Journal Title

      Journal of Osaka University Dental Society

      Volume: 56 Pages: 5-30

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Proliferation of smooth muscle cells stimulated with Porphyromonas gingivalis is inhibited by apple polyphenol2011

    • Author(s)
      Inaba H, et al
    • Journal Title

      Journal of Periodontology

      Volume: 82 Pages: 1616-1622

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell entry and exit by periodontal pathogen via recycling pathway2011

    • Author(s)
      Takeuchi H, et al
    • Journal Title

      Communicative & Integrative Biology

      Volume: 4 Pages: 587-589

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell entry and exit by periodontal pathogen Porphyromonas gingivalis2011

    • Author(s)
      Amano A, et al
    • Journal Title

      Journal of Oral Bioscience

      Volume: 54 Pages: 54-57

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯周病と4つの全身疾患2011

    • Author(s)
      天野敦雄, 他
    • Journal Title

      臨床薬理

      Volume: 42 Pages: 65-66

    • NAID

      10029432651

    • Related Report
      2011 Annual Research Report
  • [Presentation] Unique strategic system of Porphyromonas gingivalis in periodontitis2014

    • Author(s)
      Amano A
    • Organizer
      Kyudai Oral Bioscience 2014, 8th International Symposium
    • Place of Presentation
      Hakata
    • Year and Date
      2014-03-01
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Involvement of VAMP2 in intracellular localization of Porphyromonas gingivalis2014

    • Author(s)
      Takeuchi H, Takada A, Amano A
    • Organizer
      92nd IADR General Session
    • Place of Presentation
      Cape Town
    • Related Report
      2013 Annual Research Report
  • [Presentation] Tumor necrosis factor  in saliva may be a novel marker of carotid atherosclerosis: The Suita Study2014

    • Author(s)
      Kosaka T, Kokubo Y, Ono T, Sekine S, Kida M, Kikui M, Yamamoto M, Watanabe M, Amano A, Maeda Y, Miyamoto Y
    • Organizer
      European Stroke Conference
    • Place of Presentation
      Nice
    • Related Report
      2013 Annual Research Report
  • [Presentation] Molecular basis of periodontal destruction by periodontal bacteria2013

    • Author(s)
      Amano A
    • Organizer
      Exchange seminar between Osaka University and National Taiwan University
    • Place of Presentation
      Taipei
    • Year and Date
      2013-12-24
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Invited
  • [Presentation] P. gingivalis の歯周組織破壊戦略-変貌する歯周病因論-サテライトシンポジウム10 歯周病菌による歯周組織破壊メカニズム : 現状と展望2013

    • Author(s)
      天野敦雄
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山市
    • Year and Date
      2013-09-20
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Molecular basis of periodontal destruction by periodontal bacteria. JADR-sponsored symposium2013

    • Author(s)
      Amano A
    • Organizer
      2nd meeting of IADR-Asia Pacific Region
    • Place of Presentation
      Bangkok
    • Year and Date
      2013-08-21
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 口腔から挑むBioResearch : Dental Science のときめき. シンポジウム「トレンドメーカーによるサイエンティフィック・エクスチェンジ」2013

    • Author(s)
      天野敦雄
    • Organizer
      第62回口腔衛生学会
    • Place of Presentation
      松本
    • Year and Date
      2013-05-16
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Strategy of periodontal bacteria for periodontal destruction2013

    • Author(s)
      Amano A
    • Organizer
      Seminar at School of Dentistry University of Louisville
    • Place of Presentation
      Louisville, Kentucky
    • Year and Date
      2013-03-18
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Invited
  • [Presentation] Strategy of periodontal bacteria for periodontal destruction2013

    • Author(s)
      Amano A
    • Organizer
      Seminar at Penn Dental
    • Place of Presentation
      Philadelphia, Pennsylvania
    • Year and Date
      2013-03-15
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Invited
  • [Presentation] Strategy of P. gingivalis for periodontal destruction2012

    • Author(s)
      Amano A
    • Organizer
      First international conference on Porphyromonas gingivalis and related bacterial species
    • Place of Presentation
      Nagasaki
    • Year and Date
      2012-08-28
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 基礎研究が指し示す歯周病因論自由集会5「歯科における健康を科学する」2012

    • Author(s)
      天野敦雄
    • Organizer
      第61回口腔衛生学会
    • Place of Presentation
      横須賀
    • Year and Date
      2012-05-27
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Starategy of periodontal bacteria for periodontal destruction2012

    • Author(s)
      Amano A
    • Organizer
      The 2^<nd> International Joint Symposium on Oral and Dental Sciences
    • Place of Presentation
      Yogjakarta (Indonesia)(招待講演)
    • Year and Date
      2012-03-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 口腔領域の遺伝子診断「病因論から予測する歯周病発症リスク」2011

    • Author(s)
      天野敦雄
    • Organizer
      大阪府病院診療所歯科部長会・研修会
    • Place of Presentation
      ホテルモントレー大阪(大阪市)(招待講演)
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 病因論から再考する歯周治療障害者歯科学会教育講座2011

    • Author(s)
      天野敦雄
    • Organizer
      第28回日本障害者歯科学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-05
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 病因論から再考する歯周治療2011

    • Author(s)
      天野敦雄
    • Organizer
      障害者歯科学会教育講座、第28回日本障害者歯科学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡市)(招待講演)
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Outer membrane vesicles function as offensive weapons of Porphyromonas gingivalis2011

    • Author(s)
      Amano A
    • Organizer
      The Second Osaka Mahidol Chulalongkorn Joint Symposium
    • Place of Presentation
      Bangkok
    • Year and Date
      2011-10-25
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Outer membrane vesicles function as offensive weapons of Porphyromonas gingivalis2011

    • Author(s)
      Amano A
    • Organizer
      The Second Osaka Mahidol Chulalongkorn Joint Symposium
    • Place of Presentation
      Bangkok (Thailand)(招待講演)
    • Year and Date
      2011-10-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Outer membrane vesicles function as offensive weapons of Porphyromonas gingivalis2011

    • Author(s)
      Amano A
    • Organizer
      13rd International Congress of Bacteriology and Applied Microbiology
    • Place of Presentation
      Sapporo
    • Year and Date
      2011-09-03
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Outer membrane vesicles function as offensive weapons of Porphyromonas gingivalis2011

    • Author(s)
      Amano A
    • Organizer
      13rd International Congress of Bacteriology and Applied Microbiology
    • Place of Presentation
      札幌コンベンションセンター(札幌市)(招待講演)
    • Year and Date
      2011-09-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Strategy of periodontal bacteria for periodontal destruction. Periodontik Terkini2011

    • Author(s)
      Amano A
    • Organizer
      Universitas Gadjah Mada
    • Place of Presentation
      Yogjakarta, Indonesia
    • Year and Date
      2011-07-04
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Strategy of periodontal bacteria for periodontal destruction2011

    • Author(s)
      Amano A
    • Organizer
      Periodontik Terkini, Universitas Gadjah Mada
    • Place of Presentation
      ガジャマダ大学(Indonesia)(招待講演)
    • Year and Date
      2011-07-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細菌感染症の転帰を決める細胞ロジスティクス機構の分子基盤解析2011

    • Author(s)
      天野敦雄, 他
    • Organizer
      新学術領域「細胞内ロジスティクス」班会議
    • Place of Presentation
      鳥羽シーサイドホテル(鳥羽市)
    • Year and Date
      2011-06-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歯周ポケット内細菌叢の複雑化が脂質プロフィールに与える影響

    • Author(s)
      清原宏之,小島美樹,小野高裕,泉井秀介,関根伸一,永田英樹,天野敦雄
    • Organizer
      第63回口腔衛生学会学術大会
    • Place of Presentation
      博多
    • Related Report
      2013 Annual Research Report
  • [Presentation] Porphyromonas gingivalisがStreptococcus oralisのタンパク質発現に及ぼす影響

    • Author(s)
      前田和彦、永田英樹、小島美樹、関根伸一、泉井秀介、天野敦雄
    • Organizer
      第63回口腔衛生学会学術大会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] クルクミンが歯周病菌の生育およびバイオフィルム形成に及ぼす影響

    • Author(s)
      泉井秀介、関根伸一、高田明比古、前田和彦、久保庭雅恵、永田英樹、天野敦雄
    • Organizer
      第63回口腔衛生学会学術大会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 口腔清掃状態の唾液メタボロームへの影響

    • Author(s)
      坂中哲人、久保庭雅恵、橋野恵衣、天野敦雄
    • Organizer
      第63回口腔衛生学会学術大会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 研究論入門:いい研究者になるための法則

    • Author(s)
      天野敦雄
    • Organizer
      第63回口腔衛生学会学術大会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Unique strategic system of Porphyromonas gingivalis in periodontitis

    • Author(s)
      Amano A
    • Organizer
      Kyudai Oral Bioscience 2014, 8th International Symposium
    • Place of Presentation
      博多
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] クルクミンが歯周病菌の増殖とプロテアーゼ活性に及ぼす影響

    • Author(s)
      泉井秀介、関根伸一、前田和彦、永田英樹、天野敦雄
    • Organizer
      第24回近畿・中国・四国口腔衛生学会学術大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report
  • [Presentation] 口腔レンサ球菌との混合培養におけるPorphyromonas gingivalisタンパク質発現のショットガンプロテオミクス

    • Author(s)
      前田和彦、永田英樹、小島美樹、天野敦雄
    • Organizer
      第24回近畿・中国・四国口腔衛生学会学術大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report
  • [Presentation] Molecular basis of periodontal destruction by periodontal bacteria

    • Author(s)
      Amano A
    • Organizer
      2nd meeting of IADR-Asia Pacific Region
    • Place of Presentation
      Bangkok
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Molecular dissection of intracellular sorting of Porphyromonas gingivalis to autophagosomes

    • Author(s)
      Takada A, Furuta N, Takeuchi H, Amano A
    • Organizer
      2nd meeting of IADR-Asia Pacific Region
    • Place of Presentation
      Bangkok
    • Related Report
      2013 Annual Research Report
  • [Presentation] Metabolome profiles of polyol-treated Filifactor alocis

    • Author(s)
      Hashino E, Kuboniwa M, Alghamdi SA, Cho H, Amano A
    • Organizer
      2nd meeting of IADR-Asia Pacific Region
    • Place of Presentation
      Bangkok
    • Related Report
      2013 Annual Research Report
  • [Presentation] P. gingivalisの歯周組織破壊戦略-変貌する歯周病因論-

    • Author(s)
      天野敦雄
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Exit of intracellular Porphyromonas gingivalis from gingival epithelial cells is mediated by endocytic recycling pathway

    • Author(s)
      竹内洋輝、天野敦雄
    • Organizer
      第116回大阪大学歯学会例会
    • Place of Presentation
      吹田
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 小型印刷電極を用いたP. gingivalis II型線毛株検出システムの臨床応用

    • Author(s)
      関根伸一、橋野恵衣、久保庭雅恵、永田英樹、天野敦雄
    • Organizer
      第61回口腔衛生学会学術大会
    • Place of Presentation
      松本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯肉上皮細胞由来ポリアミンがPorphyromonas gingivalisの病原性に及ぼす影響

    • Author(s)
      久保庭雅恵、稲葉裕明、Samar Alghamdi、橋野恵衣、天野敦雄
    • Organizer
      第61回口腔衛生学会学術大会
    • Place of Presentation
      松本
    • Related Report
      2013 Annual Research Report
  • [Presentation] Porphyromonas gingivalis MDHの混合バイオフィルム形成に及ぼす阻害効果

    • Author(s)
      前田和彦、永田英樹、小島美樹、天野敦雄
    • Organizer
      第61回口腔衛生学会学術大会
    • Place of Presentation
      松本
    • Related Report
      2013 Annual Research Report
  • [Presentation] Porphyromonas gingivalis感染がヒト口腔癌細胞の浸潤能に及ぼす影響

    • Author(s)
      稲葉裕明、久保庭雅恵、天野敦雄
    • Organizer
      第61回口腔衛生学会学術大会
    • Place of Presentation
      松本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯の欠損の治療放置は高血圧管理に影響を与えるか?

    • Author(s)
      小島美樹、天野敦雄、倉田 秀
    • Organizer
      第61回口腔衛生学会学術大会
    • Place of Presentation
      松本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 口腔から挑むBioResearch:Dental Scienceのときめき

    • Author(s)
      天野敦雄
    • Organizer
      第61回口腔衛生学会学術大会
    • Place of Presentation
      松本
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 病因論で語るClinical Periodontology

    • Author(s)
      天野敦雄
    • Organizer
      第11回国際歯周内科学研究会学術大会
    • Place of Presentation
      博多
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 21世紀のペリオドントロジ- -最新病因論にそった診断・治療、発症予測-

    • Author(s)
      天野敦雄
    • Organizer
      第442回大阪大学歯学部同窓会臨床談話会
    • Place of Presentation
      吹田
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Molecular basis of periodontal destruction by periodontal bacteria

    • Author(s)
      Amano A
    • Organizer
      2nd meeting of IADR-Asia Pacific Region
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Osaka university graduate school of dentistry opens the Frontier of Biodentistry

    • Author(s)
      Amano A
    • Organizer
      The first Japan-Thailand-Korea joint symposium on translational research in oral sciences
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] First international conference on Porphyromonas gingivalis and related bacterial species

    • Author(s)
      Amano A
    • Organizer
      Strategy of P. gingivalis for periodontal destruction
    • Place of Presentation
      Nagasaki
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 口腔から挑むBioResearch:Dental Scienceのときめき

    • Author(s)
      天野敦雄
    • Organizer
      第62回口腔衛生学会
    • Place of Presentation
      松本
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 基礎研究が指し示す歯周病因論

    • Author(s)
      天野敦雄
    • Organizer
      第61回口腔衛生学会
    • Place of Presentation
      横須賀
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The autophagosome forms at ER−mitochondria contact sites

    • Author(s)
      Hamasaki M
    • Organizer
      Annual meeting of American Society for Cell Biology
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Annual Research Report
  • [Book] 糖アルコールバイオフィルムへの効果 オーラルヘルスケア機能性食品の開発と応用 : アンチエイジングを目指した口腔ケアを中心に(坂上 宏 監修)2013

    • Author(s)
      橋野恵衣, 天野敦雄
    • Publisher
      シーエムシー出版, 東京
    • Related Report
      2013 Final Research Report
  • [Book] オーラルヘルスケア機能性食品の開発と応用:アンチエイジングを目指した口腔ケアを中心に2013

    • Author(s)
      橋野恵衣,天野敦雄
    • Total Pages
      243
    • Publisher
      シーエムシー出版
    • Related Report
      2013 Annual Research Report
  • [Book] Genotyping of periodontal anaerobic bacteria in relationship to pathogenesis. In de Filipis I, McKee ML (ed.), Molecular typing in bacterial infections2012

    • Author(s)
      Kuboniwa M, Amano A*
    • Publisher
      Springer, NY, U.S.A
    • Related Report
      2013 Final Research Report
  • [Book] 歯周病の発症 ビジュアル歯周病を科学する(天野敦雄, 村上伸也, 岡賢二 編)2012

    • Author(s)
      天野敦雄
    • Publisher
      クインテッセンス出版, 東京
    • Related Report
      2013 Final Research Report
  • [Book] 歯周組織内に生息する歯周病菌 ビジュアル 歯周病を科学する(天野敦雄, 村上伸也, 岡 賢二 編)2012

    • Author(s)
      天野敦雄
    • Publisher
      クインテッセンス出版, 東京
    • Related Report
      2013 Final Research Report
  • [Book] 歯周病原菌red complex の宿主傷害戦略 ビジュアル 歯周病を科学する(天野敦雄, 村上伸也, 岡 賢二 編)2012

    • Author(s)
      天野敦雄
    • Publisher
      クインテッセンス出版, 東京
    • Related Report
      2013 Final Research Report
  • [Book] オートファジーと感染・免疫オートファジー(水島 昇・吉森 保 編)2012

    • Author(s)
      天野敦雄
    • Publisher
      化学同人, 京都
    • Related Report
      2013 Final Research Report
  • [Book] オートファジー2012

    • Author(s)
      天野敦雄
    • Total Pages
      230
    • Publisher
      化学同人
    • Related Report
      2012 Annual Research Report
  • [Book] ビジュアル 歯周病を科学する2012

    • Author(s)
      天野敦雄
    • Total Pages
      348
    • Publisher
      クインテッセンス出版
    • Related Report
      2012 Annual Research Report
  • [Book] 歯周病を科学する2012

    • Author(s)
      天野敦雄, 他
    • Publisher
      クインテッセンス出版
    • Related Report
      2011 Annual Research Report
  • [Book] 病原菌の今日的意味2011

    • Author(s)
      天野敦雄, 他
    • Publisher
      医薬ジャーナル
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://web.dent.osaka-u.ac.jp/~prevent/

    • Related Report
      2013 Final Research Report
  • [Remarks] 予防歯科学教室 研究活動

    • URL

      http://web.dent.osaka-u.ac.jp/~prevent/research.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 大阪大学最新研究成果リリース

    • URL

      http://www.osaka-u.ac.jp/ja/news/ResearchRelease/2013/03/20130304_1

    • Related Report
      2012 Annual Research Report
  • [Remarks] 大阪大学最新研究成果リリース

    • URL

      http://www.osaka-u.ac.jp/ja/news/ResearchRelease/2012/04/20120410_1

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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