Anti-aging trial through oxidative stress control in oral region

• Project/Area Number: 23390480
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Okayama University
• Principal Investigator: MORITA Manabu 岡山大学, 医歯(薬)学総合研究科, 教授 (40157904)
• Co-Investigator(Kenkyū-buntansha): TOMOFUJI Takaaki 岡山大学, 大学病院, 講師 (80335629) ; TAMAKI Naofumi 徳島大学, 大学院・ヘルスバイオサイエンス研究部(歯学系), 准教授 (20335615) ; EKUNI Daisuke 岡山大学, 大学病院, 講師 (70346443) ; KANEHIRA Takashi 北海道大学, 大学病院, 講師 (90194935)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2011: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 酸化ストレス / 栄養 / 歯周病 / 水素水 / 歯周治療 / アタアッチメントロス

Research Abstract

The present clinical study aimed to clarify the interrelationship between periodontal health and dietary/hydrogen-rich water intake based on the systemic oxidative stress control. In the subjects with higher oxidative stress at baseline, relationship between periodontal disease progression and oxidative stress was apparent, whereas not with lower oxidative stress. The intake of 3 cups of coffee/day or more or intake of hydrogen-rich water showed inhibitory effect on periodontal disease.

Research Products

• [Journal Article] Longitudinal relationship between plasma reactive oxygen metabolites and periodontal condition in the maintenance phase of periodontal treatment (2014)
  • Author(s): Machida T, Tomofuji T, Ekuni D, Yamane M, Yoneda T, Kawabata Y, Kataoka K. TamakiN, Morita M
  • Journal Title: Disease Marker Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Longitudinal relationship between plasma reactive oxygen metabolites and periodontal condition in the maintenance phase of periodontal treatment
  • Author(s): Tatsuya Machida, Takaaki Tomofuji, Daisuke Ekuni, Mayu Yamane, Toshiki Yoneda, Yuya Kawabata, Kota Kataoka, Naofumi Tamaki, Manabu Morita
  • Journal Title: Disease Marker Volume: (in press)
  • Peer Reviewed
• [Presentation] Relationship between plasma reactive oxygen species and progression of periodontitis (2012)
  • Author(s): Naofumi Tamaki
  • Organizer: 10th AAPD meeting
  • Place of Presentation: Ulaanbaatar, Mongolia