| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Research Abstract |
we investigated whether newly identified adipokine apelin had an inhibitory effect on inflammatory response in lipopolysaccharide (LPS) -treated macrophage. Pretreatment with apelin significantly reduced the production of proinflammatory cytokines in LPS-treated macrophage-like cell line, J774.1 cell. In addition, apelin pretreatment significantly reduced the LPS-induced phosphorylation of p38 MAPK and JNK, but not ERK. To the best of our knowledge, this is the first report that the apelin peptide family has anti-inflammatory effects against bacterial LPS stimulation in macrophages.
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