| Project/Area Number |
23404007
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Living organism molecular science
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHSAKI Ayumi 日本大学, 文理学部, 准教授 (50161360)
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| Co-Investigator(Renkei-kenkyūsha) |
ARAI A. MIDORI 千葉大学, 大学院薬学研究院, 准教授 (40373261)
TOUME Kazufumi 千葉大学, 大学院薬学研究院, 助教 (80563981)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 薬学 / 生理活性 / 植物 / 有機化学 / シグナル伝達 / 資源調査 / 天然物 / スクリーニング |
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| Outline of Final Research Achievements |
In 2011-2014 the representative of this research project (Masami Ishibashi) visited Bangladesh every year and investigated field-study on natural medicinal resources in Bangladesh mainly on tropical plants. As a result, more than 100 kinds of plant samples were collected. They are mostly characterictic kinds of plants in Bangladesh. Extracts of these plant materials were subjected to screening tests against signaling pathways such as Wnt, hedgehog, and TRAIL, and from extracts of hit samples, several new bioactive natural products were isolated, and their biological effects on signaling pathways were examined.
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