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International comparative research on exposure and biological effects of air pollution for local residents in Asia

Research Project

Project/Area Number 23406004
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Environmental and hygienic pharmacy
Research InstitutionKanazawa University

Principal Investigator

TORIBA Akira  金沢大学, 薬学系, 准教授 (50313680)

Co-Investigator(Kenkyū-buntansha) HAYAKAWA Kazuichi  金沢大学, 薬学系, 教授 (40115267)
KAMEDA Takayuki  京都大学, エネルギー科学研究科, 准教授 (50398426)
TANG Ning  金沢大学, 薬学系, 助教 (90372490)
Research Collaborator SIMPSON Christopher D.  ワシントン大学(米国), 准教授
CHETIYANUKORNKUL Thaneeya  チェンマイ大学(タイ), 助教
LI Jun Dong  瀋陽市疾病預防控制中心(中国), 主任
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywordsバイオマーカー / 大気汚染 / アジア / 有害化学物質 / 曝露評価 / PM2.5 / 国際研究者交流 / 国際研修者交流(タイ)
Outline of Final Research Achievements

The rapid development of Asian countries has caused serious air pollution problems, and there are fears of increased risk of various diseases. The elucidation of the environmental factors such as exposure and sources of air pollutants is important for risk assessment of health effects. In this study, we developed biological markers (biomarkers) from pollutants that are excreted in the urine and evaluated the usefulness of the biomarkers by analyzing the exposure amounts and sources with residents of Asian region having different characteristic of air pollution. High-exposure to polycyclic aromatic hydrocarbons of the subject group in the rural villages of Thailand mountainous areas was clarified by the measurement of the biomarkers. It was caused by exposure to wood burning smoke from cooking inside the houses. In conclusion, the usefulness of the developed biomarkers was demonstrated.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (39 results)

All 2015 2014 2013 2012 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (24 results) (of which Invited: 1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarnons in atmospheric particles and soil at a traffic site in Hanoi, Vietnam.2015

    • Author(s)
      Pham, C. T., Tang, N., Toriba, A., Hayakawa, K.
    • Journal Title

      Polycyclic Aromatic Compounds

      Volume: 印刷中 Issue: 5 Pages: 0-8

    • DOI

      10.1080/10406638.2014.903284

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atmospheric chlorinated polycyclic aromatic hydrocarbons in East Asia2014

    • Author(s)
      K. Kakimoto, H. Nagayoshi, Y. Konishi, K. Kajimura, T. Ohura, K. Hayakawa, A. Toriba
    • Journal Title

      Chemosphere

      Volume: 111 Pages: 40-46

    • DOI

      10.1016/j.chemosphere.2014.03.072

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of biomass burning on the levels of atmospheric polycyclic aromatic hydrocarbons and their nitro derivatives in Chiang Mai, Thailand.2014

    • Author(s)
      Chuesaard, T., Chetiyanukornkul, T., Kameda, T., Hayakawa, K., Toriba, A.
    • Journal Title

      Aerosol and Air Quality Research

      Volume: 14 (4) Issue: 4 Pages: 1247-1257

    • DOI

      10.4209/aaqr.2013.05.0161

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Atmospheric Behaviors of Polycyclic Aromatic Hydrocarbons in East Asia2014

    • Author(s)
      Hayakawa, K., Tang, N., Kameda, T., Toriba, A.
    • Journal Title

      Genes and Environment

      Volume: 36 Issue: 3 Pages: 152-159

    • DOI

      10.3123/jemsge.2014.016

    • NAID

      130004943665

    • ISSN
      1880-7046, 1880-7062
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Polycyclic aromatichydrocarbons and nitropolycyclic aromatic hydrocarnons in soil and atmospheric particles at a traffic site in Hanoi, Vietnam.2014

    • Author(s)
      Pham, C. T., Tang, N., Toriba, A., Hayakawa, K.
    • Journal Title

      Polycyclic Aromatic Compounds

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factors affecting atmospheric 1-, 2-nitropyrenes and 2-nitrofluoranthene in winter at Noto peninsula, a remote background site2014

    • Author(s)
      Tang, N., Sato, K., Tokuda, T., Tatematsu, M., Hama, H., Suematsu, T., kameda, T., Toriba, A., Hayakawa, K.
    • Journal Title

      Chemosphere

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantification of Polycyclic Aromatic Hydrocarbons (PAHs) in Cigarette Smoke Particulates by HPLC with Fluorescence Detection2014

    • Author(s)
      鳥羽 陽,本間千春,宇於崎和香,Thanyarat Chuesaard,唐 寧,早川和一
    • Journal Title

      BUNSEKI KAGAKU

      Volume: 63 Issue: 1 Pages: 23-29

    • DOI

      10.2116/bunsekikagaku.63.23

    • NAID

      130003391209

    • ISSN
      0525-1931
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological Effects of Polycyclic Aromatic Hydrocarbon Derivatives2013

    • Author(s)
      Bekki, K., Toriba, A., Tang, N., Kameda, T., Hayakawa, K.
    • Journal Title

      Journal of UOEH

      Volume: 35 Issue: 1 Pages: 17-24

    • DOI

      10.7888/juoeh.35.17

    • NAID

      110009593197

    • ISSN
      0387-821X, 2187-2864
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of Atmospheric Polycyclic Aromatic Hydrocarbons in Shenyang, Shanghai and Fuzhou, China2013

    • Author(s)
      唐 寧, 伊崎陽彦, 徳田貴裕, 季 若男, 薫 麗君, 呉 慶, 周 志俊, 黄 蓉, 林振宇, 亀田貴之, 鳥羽 陽,島 正之, 早川和一
    • Journal Title

      BUNSEKI KAGAKU

      Volume: 62 Issue: 4 Pages: 267-273

    • DOI

      10.2116/bunsekikagaku.62.267

    • NAID

      10031151799

    • ISSN
      0525-1931
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polycyclic atmospheric polycyclic hydrocarbons and nitropolycyclic aromatic hydrocarnons in particulates emitted by motorcycles2013

    • Author(s)
      Pham, C. T., Kameda, T., Toriba, A., Hayakawa, K
    • Journal Title

      Envion. Pollutiton

      Volume: 183(1) Pages: 175-183

    • DOI

      10.1016/j.envpol.2013.01.003

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of urinary metabolites of 1-nitropyrene as biomarkers for exposure to diesel exhaust in taxi drivers of Shenyang, China2013

    • Author(s)
      Miller-Schulze, JP., Paulsen, M., Kameda, T., Toriba, A., Tang, N., Tamura, K., Dong, L., Zhang, X., Hayakawa, K., Yost, MG., Simpson, CD
    • Journal Title

      J. Expo Sci. Environ. Epidemiol

      Volume: 23(2) Issue: 2 Pages: 170-175

    • DOI

      10.1038/jes.2012.40

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of atmospheric polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarnons in Hanoi-Vietnam, as a typical motorbike city2012

    • Author(s)
      Pham, C. T., Kameda, T., Toriba A., Tang, N., Hayakawa, K
    • Journal Title

      Polycycl. Aromat. Comp

      Volume: 32(2) Issue: 2 Pages: 296-312

    • DOI

      10.1080/10406638.2012.679015

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of 8-hydroxy-2’-deoxyguanosine in human urine using hydrophilic interaction chromatography with tandem mass spectrometry2012

    • Author(s)
      C. Hosozumi
    • Journal Title

      J. Chromatogr. B

      Volume: 893 - 894 Pages: 173-176

    • DOI

      10.1016/j.jchromb.2012.02.043

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 中国瀋陽市において走行するタクシー車両内で捕集した大気中ナノ粒子に含まれる多環芳香族炭化水素類の分析2015

    • Author(s)
      加賀野井祐一,比嘉志歩,唐 寧,符 文華,斉 宏業,畑 光彦,古内正美,早川和一,鳥羽 陽
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      デザイン・クリエイティブセンター神戸、神戸サンポ―ホール、神戸学院大学、兵庫医療大学(兵庫県)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Exposure Assessment of Taxi Drivers to Environmental Nanoparticles in Shenyang, China.2014

    • Author(s)
      Toriba, A., Kaganoi, Y., Tang, N., Fu, W., Qi, H., Hata, M., Furuuchi, M., Hayakawa, K.
    • Organizer
      International Conference of Asian Environmental Chemistry 2014
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2014-11-24 – 2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中国瀋陽市のタクシー車内における携帯型ナノ粒子サンプラーを用いた大気中のナノ粒子捕集と多環芳香族炭化水素類の分析2014

    • Author(s)
      比嘉志歩,加賀野井祐一,唐 寧,符 文華,斉 宏業,畑 光彦,古内正美,早川和一,鳥羽 陽
    • Organizer
      日本薬学会北陸支部第126回例会
    • Place of Presentation
      金沢大学(石川県)
    • Year and Date
      2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Exposure Assessment of Taxi Drivers to Environmental Nanoparticles in Shenyang, China.2014

    • Author(s)
      Toriba, A., Kaganoi, Y., Tang, N., Fu, W., Qi, H., Hata, M., Furuuchi, M., Hayakawa, K.
    • Organizer
      2014 International Society of Exposure Science 24th Annual Meeting
    • Place of Presentation
      Cincinnati, Ohio, USA
    • Year and Date
      2014-10-12 – 2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中国・瀋陽市のタクシー車内で捕集した環境ナノ粒子中の多環芳香族炭化水素類の測定2014

    • Author(s)
      鳥羽 陽,加賀野井祐一,唐 寧,符 文華,斉 宏業,畑 光彦,古内正美
    • Organizer
      第55回大気環境学会年会
    • Place of Presentation
      愛媛大学城北キャンパス(愛媛県)
    • Year and Date
      2014-09-17 – 2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中国・瀋陽市におけるタクシー運転手の環境ナノ粒子曝露調査2014

    • Author(s)
      鳥羽 陽,加賀野井祐一,唐 寧,符 文華,斉 宏業,畑 光彦,古内正美,早川和一
    • Organizer
      第23回環境化学討論会
    • Place of Presentation
      京都大学百周年記念時計台記念館(京都府)
    • Year and Date
      2014-05-14 – 2014-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] たばこ煙中多環芳香族炭化水素キノン類の喫煙法の違いによる濃度比較2014

    • Author(s)
      宇於崎和香,鳥羽 陽,北 将大,本間千春,唐 寧,早川和一
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学(熊本県熊本市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] GC-MS/MSによる大気粉塵中多環芳香族炭化水素キノン類の定量と発生源解析2014

    • Author(s)
      本間千春,鳥羽 陽,宇於崎和香,北 将大,唐 寧,早川和一
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学(熊本県熊本市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ナノ粒子個人サンプラーにより生活環境で捕集したナノ粒子中の多環芳香族炭化水素類の分析2014

    • Author(s)
      加賀野井祐一,鳥羽 陽,Thongyen THUNYAPAT,畑 光彦,古内正美,唐 寧,早川和一
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学(熊本県熊本市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] たばこ煙中に含まれる多環芳香族炭化水素キノン類の測定2013

    • Author(s)
      鳥羽 陽,宇於崎和香,唐 寧,早川和一
    • Organizer
      フォーラム2013:衛生薬学・環境トキシコロジー
    • Place of Presentation
      九州大学(福岡県福岡市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] GC-MSによる大気中水酸化多環芳香族炭化水素類の分析法開発2013

    • Author(s)
      笠原千栄子,鳥羽 陽,唐 寧,早川和一
    • Organizer
      日本分析化学会第62年会
    • Place of Presentation
      近畿大学(大阪府東大阪市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 大気粉じん中多環芳香族炭化水素キノン類の分析2013

    • Author(s)
      鳥羽 陽,北 将大,唐 寧,亀田貴之,早川和一
    • Organizer
      第22回環境化学討論会
    • Place of Presentation
      東京農工大学(東京都府中市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 大気および食品中ハロゲン系難燃剤の曝露量評価2013

    • Author(s)
      柿本健作,高木総吉,阿久津和彦,東條俊樹,先山孝則,小西良昌,梶村計志,鳥羽 陽,早川和一
    • Organizer
      第22回環境化学討論会
    • Place of Presentation
      東京農工大学(東京都府中市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] GC-MS/MSによる大気粉じん中多環芳香族炭化水素キノン類の分析2013

    • Author(s)
      鳥羽 陽,北 将大,本間千春,早川和一
    • Organizer
      第73回分析化学討論会
    • Place of Presentation
      北海道大学(北海道函館市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Comparison of polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in particulates between motorcycle and automobile exhausts2013

    • Author(s)
      Chau Thuy Pham
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Influence of biomass burning on the levels of atmospheric polycyclic aromatic hydrocarbons and their nitrated derivatives in Chiang Mai, Thailand.2013

    • Author(s)
      Thanyarat Chuesaard
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 活性酸素種を生成する9,10-phenanthrenequinoneのヒト尿中代謝物の測定2012

    • Author(s)
      旭美樹
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] GC-MS/MSによる大気粉じん中水酸化多環芳香族炭化水素類の測定2012

    • Author(s)
      鳥羽陽
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] GC-MS/MSによる大気粉じん中多環芳香族炭化水素キノン類の一斉分析法の開発2012

    • Author(s)
      北将大
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 東南アジア諸国の大気汚染実態2012

    • Author(s)
      鳥羽 陽
    • Organizer
      日本環境変異原学会第41回大会
    • Place of Presentation
      静岡県コンベンションアーツセンター(静岡)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Identification and quantification of the urinary metabolites of 9, 10-phenanthrenequinone associated with producing reactive oxygen species2012

    • Author(s)
      Akira Toriba
    • Organizer
      2nd annual meeting of the international society of exposure science (ISES2012)
    • Place of Presentation
      Westin Seattle (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] タイ住民を対象とした多環芳香族炭化水素キノン誘導体の尿中代謝物測定2012

    • Author(s)
      旭 美樹
    • Organizer
      フォーラム2012:衛生薬学・環境トキシコロジー
    • Place of Presentation
      名古屋観光ホテル(愛知)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in motorcycle exhaust particulates and atmosphere in Hanoi, Vietnam2012

    • Author(s)
      Chau Thuy Pham
    • Organizer
      フォーラム2012:衛生薬学・環境トキシコロジー
    • Place of Presentation
      名古屋観光ホテル(愛知)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 活性酸素種を生成する多環芳香族炭化水素キノン誘導体のヒト尿中代謝物の測定2012

    • Author(s)
      鳥羽 陽
    • Organizer
      日本分析化学会第61年会
    • Place of Presentation
      金沢大学(石川)
    • Related Report
      2012 Annual Research Report
  • [Book] 毒性の科学2014

    • Author(s)
      熊谷嘉人,姫野誠一郎,渡辺知保,長沼章,黄基旭,角大悟,佐藤雅彦,中西剛,武田厚司,吉永淳,吉岡亘,鳥羽陽,平野靖史郎 他
    • Total Pages
      216
    • Publisher
      東京大学出版会
    • Related Report
      2013 Annual Research Report
  • [Remarks] 金沢大学衛生化学研究室ホームページ

    • URL

      http://www.p.kanazawa-u.ac.jp/~eisei/j_home_framepage.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-15   Modified: 2019-07-29  

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