Research on the anticancer effects and multidrug-resistance modulating effects of Thai plants

• Project/Area Number: 23406005
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Medical pharmacy
• Research Institution: Hiroshima University
• Principal Investigator: TAKANO Mikihisa 広島大学, 医歯薬保健学研究院(薬), 教授 (20211336)
• Co-Investigator(Renkei-kenkyūsha): YUMOTO Ryoko 広島大学, 大学院医歯薬保健学研究院, 講師 (70379915)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
• Keywords: 薬学 / タイ植物 / がん治療 / 抗がん作用 / 耐性克服作用 / Zingiberaceae科 / Kaempferia marginata / 抗がん剤耐性克服作用 / P-糖タンパク質 / パクリタキセル / ヒト肝がん細胞 / ドイ・プイ地域 / Kaempferia parviflora / 抗ガン剤耐性克服作用 / Ellipeiopsis cherrevensis / ネクローシス / 活性酸素種

Outline of Final Research Achievements

Ten extracts from Thai plants belonging to the families of Annonaceae, Rutaceae, and Zingiberaceae were obtained, in order to test anticancer effects and multidrug-resistance modulating (P-glycoprotein inhibiting) effects. The extract from Ellipeiopsis cherrevensis showed potent anticancer effects under in vitro as well as in vivo conditions, and the extract was found to induce necrosis in cancer cells. The extracts from Curcuma comosa and Kaempferia marginata showed potent P-glycoprotein inhibitory effects. These Thai plants would be a useful source to search for new anticancer drugs and multidrug-resistance modulators.

Research Products

• [Journal Article] Receptor-mediated endocytosis of macromolecules and strategy to enhance their transport in alveolar epithelial cells. (2015)
  • Author(s): Takano, M., Aoki, A., Kawami, M. and Yumoto, R.
  • Journal Title: Expert Opinion on Drug Delivery Volume: 13 Issue: 5 Pages: 331-337
  • DOI: 10.1517/17425247.2015.992778
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of TGF-β1-and drug-induced epithelial-mesenchymal transition in cultured alveolar epithelial cell line RLE/Abca3 (2015)
  • Author(s): Takano, M., Yamamoto, C., Yamaguchi, K., Kawami, M. and Yumoto, R.
  • Journal Title: Drug Metab. Pharmacokinet. Volume: 30 Issue: 1 Pages: 111-118
  • DOI: 10.1016/j.dmpk.2014.10.007
  • NAID: 50014415988
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Transport across the cell membrane and its regulation by vesicular transportTransport across the cell membrane and its regulation by vesicular transport (2015)
  • Author(s): Takano, M., Kawami, M. and Yumoto, R.
  • Journal Title: Membrane Volume: 40 Pages: 21-28
  • Peer Reviewed
• [Journal Article] Modulation of P-glycoprotein function and multidrug resistance in cancer cells by Thai plant extracts. (2014)
  • Author(s): Takano, M., Kakizoe, S., Kawami M., Nagai J., Patanasethanont, D., Sripanidkulchai B. and Yumoto, R.
  • Journal Title: Pharmazie Volume: 69 Pages: 823-828
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Folic acid-modified methotrexate-conjugated PEGylated poly(e-caprolactone) nanoparticles for targeted delivery. (2014)
  • Author(s): Issarachot, O., Suksiriworapong, J., Takano, M., Yumoto, R. and Junyapraser, V.B.
  • Journal Title: J. Nanopart. Res. Volume: 16 Issue: 2 Pages: 2276-2290
  • DOI: 10.1007/s11051-014-2276-7
  • Peer Reviewed / Open Access
• [Journal Article] Fatty acid-bearing albumin but not fatty acid-depleted albumin induces HIF-1 activation in human renal proximal tubular epithelial cell line HK-2. (2014)
  • Author(s): Nagai, J., Yamamoto, A., Katagiri, Y., Yumoto, R., Takano, M.
  • Journal Title: Biochem Biophys Res Commun. Volume: 450 Issue: 1 Pages: 476-481
  • DOI: 10.1016/j.bbrc.2014.05.146
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Entry of aminoglycosides into renal tubular epithelial cells via endocytosisdependent and -independent pathways. (2014)
  • Author(s): Nagai, J. and Takano, M.
  • Journal Title: Biochemical Pharmacology Commentary, Volume: 90 Issue: 4 Pages: 331-337
  • DOI: 10.1016/j.bcp.2014.05.018
  • Peer Reviewed / Open Access
• [Journal Article] Flow Cytometry Analysis of Cancer Cell Death Induced by the Extract of Thai Plant <i>Ellipeiopsis cherrevensis</i> (2013)
  • Author(s): Ryoko Yumoto
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 28 Issue: 2 Pages: 159-163
  • DOI: 10.2133/dmpk.DMPK-12-NT-056
  • NAID: 130004933522
  • ISSN: 1347-4367, 1880-0920
  • Peer Reviewed / Open Access
• [Journal Article] Introduction of a single transporter gene ABCA3 directs RLE-6TN to more type II-like alveolar epithelial cells (2013)
  • Author(s): Takano, M., Yamamoto, C., Sambuichi K., Oda, K., Nagai, J., Shimamoto, A., Tahara, H. and Yumoto, R.
  • Journal Title: Membrane Volume: 38 Pages: 246-253
  • Peer Reviewed
• [Journal Article] Expression and function of PEPT2 during transdifferentiation of alveolar epithelial cells (2013)
  • Author(s): Takano, M., Horiuchi, T., Sasaki, Y., Kato Y., Nagai, J. and Yumoto, R.
  • Journal Title: Life Sciences Volume: 93 Issue: 17 Pages: 630-636
  • DOI: 10.1016/j.lfs.2013.08.008
  • Peer Reviewed / Open Access
• [Journal Article] Modulation of insulin transport by D-glucose in alveolar epithelial cells (2013)
  • Author(s): Oda, K., Yumoto, R., Nagai, J. and Takano, M.
  • Journal Title: Biomedicine & Aging Pathology Volume: 3 Issue: 4 Pages: 247-252
  • DOI: 10.1016/j.biomag.2013.09.003
  • Peer Reviewed / Open Access
• [Journal Article] Enhancing Effect of Poly(amino acid)s on Albumin Uptake in Human Lung Epithelial A549 Cells (2013)
  • Author(s): Yumoto, R., Suzuka, S., Nishimoto, S., Nagai, J. and Takano, M.
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 28 Issue: 6 Pages: 497-503
  • DOI: 10.2133/dmpk.DMPK-13-RG-028
  • NAID: 130004463336
  • ISSN: 1347-4367, 1880-0920
  • Peer Reviewed / Open Access
• [Journal Article] Albumin overload induces expression of hypoxia-inducible factor 1-alpha and its target genes in HK-2 human renal proximal tubular cell line (2013)
  • Author(s): Nagai, J., Yamamoto, A., Yumoto, R. and Takano, M.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 434 Issue: 3 Pages: 670-675
  • DOI: 10.1016/j.bbrc.2013.03.140
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of Protamine Uptake by Opossum Kidney Epithelial Cells (2013)
  • Author(s): Nagai, J., Komeda, T., Katagiri, Y., Yumoto, R., Takano, M.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 36 Issue: 12 Pages: 1942-1949
  • DOI: 10.1248/bpb.b13-00553
  • NAID: 130003382061
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pharmacokinetics of FITC-labeled immunoglobulin G in normal mice and mice with cisplatin-induced acute kidney injury, (2013)
  • Author(s): Mimaki, S., Nagai, J., Yumoto, R. and Takano, M.
  • Journal Title: Current Topics in Pharmacology Volume: 17 Pages: 25-32
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effect of gadolimium on endocytic uptake of albumin in cultured human renal proximal tubular epithelial cells. (2013)
  • Author(s): Nagai J, Kimura M, Okada Y, Yumoto R, Takano M.
  • Journal Title: Current Topics in Pharmacology Volume: 17 Pages: 33-44
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effect of cigarette smoke extract on insulin transport in alveolar epithelial cell line A549 (2012)
  • Author(s): Takano, M. Horiuchi, T., Nagai, J. and Yumoto R.
  • Journal Title: Lung Volume: 190 Issue: 6 Pages: 651-659
  • DOI: 10.1007/s00408-012-9413-9
  • Peer Reviewed
• [Journal Article] Enhancement Effect of Poly(amino acid)s on Insulin Uptake in Alveolar Epithelial Cells (2012)
  • Author(s): Oda, K., Yumoto, R., Nagai, J., Katayama, H. and Takano, M.
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 27 Issue: 6 Pages: 570-578
  • DOI: 10.2133/dmpk.DMPK-12-RG-002
  • NAID: 130004933511
  • ISSN: 1347-4367, 1880-0920
  • Peer Reviewed
• [Journal Article] Endocytic Uptake of FITC-albumin by Human Alveolar Epithelial Cell Line A549 (2012)
  • Author(s): Yumoto, R., Suzuka, S., Oda, K., Imaoka, H. and Nagai, J. and Takano, M.
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 27 Issue: 3 Pages: 336-343
  • DOI: 10.2133/dmpk.DMPK-11-RG-127
  • NAID: 130004463255
  • ISSN: 1347-4367, 1880-0920
  • Peer Reviewed
• [Journal Article] Gadolinium modulates gentamicin uptake via an endocytosis-independent pathway in HK-2 human renal proximal tubular cell line. (2012)
  • Author(s): Takeshi Sawada
  • Journal Title: European Journal of Pharmacology Volume: 84(1-3) Issue: 1-3 Pages: 146-153
  • DOI: 10.1016/j.ejphar.2012.03.030
  • Peer Reviewed
• [Journal Article] Accumulation and Photodynamic Activity of Chlorin e6 in Cisplatin-Resistant Human Lung Cancer Cells (2011)
  • Author(s): Sayo Horibe
  • Journal Title: Jouranl of Pharmaceutical Sciences Volume: 100 Issue: 7 Pages: 3010-3017
  • DOI: 10.1002/jps.22501
  • Peer Reviewed
• [Presentation] ヒト肺上皮由来H441細胞におけるペプチドトランスポーターPEPT2の発現と機能の解析 (2015)
  • Author(s): 杉本奈津美、湯元良子、EHRHARDT Carsten、高野幹久
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸学院大学
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 新たなマイクロアレイを用いた薬剤性肺障害予測システムの開発 (2015)
  • Author(s): 青木彩子、 山口晃輝、 山本千恵子、 湯元良子、大島宏之、高野幹久
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸学院大学
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 喫煙による肺胞上皮II型細胞のペプチドトランスポーターPept2の機能変動 (2014)
  • Author(s): 佐々木佳宏、岸本 海、湯元良子、高野幹久
  • Organizer: 膜シンポジウム2014
  • Place of Presentation: 神戸大学百年記念館
  • Year and Date: 2014-11-26 – 2014-11-27
• [Presentation] Evaluation of epithelial-mesenchymal transition associated with methotrexate-induced injury in cultured human alveolar epithelial cell line (2014)
  • Author(s): 川見昌史、宮本未緒花、湯元良子、高野幹久
  • Organizer: 第8回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 熊本大学
  • Year and Date: 2014-11-15 – 2014-11-16
• [Presentation] 消化管上皮細胞のトランスポーター機能に及ぼすタイ国産ショウガ科植物抽出物の影響解析 (2014)
  • Author(s): 歳森ふくこ、川見昌史、湯元良子、高野幹久
  • Organizer: 第53回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] 培養肺胞上皮細胞RLE/Abca3を用いた薬剤誘発性上皮間葉転換の解析 (2014)
  • Author(s): 山口晃輝、湯元良子、高野幹久
  • Organizer: 第53回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] TGF-βおよび肺障害性薬物による肺胞上皮II型細胞の上皮間葉転換とmiRNAの発現変動 (2014)
  • Author(s): 猫本千波、山口晃輝、湯元良子、高野幹久
  • Organizer: 第53回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] 培養肺胞上皮細胞A549におけるメトトレキサートの輸送特性解析 (2014)
  • Author(s): 宮本未緒花、川見昌史、湯元良子、高野幹久
  • Organizer: 第53回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] Effect of cigarette smoke extract on PEPT2 function in alveolar epithelial cells (2014)
  • Author(s): Yumoto, R., Sasaki, Y., Takano, M.
  • Organizer: JSSX-ISSX Joint Meeting
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2014-10-18 – 2014-10-23
• [Presentation] Transport of nicotine, an organic cation, in alveolar epithelial cells (2014)
  • Author(s): Nagahiro, M., Sasaki, Y., Yumoto, R., Takano, M.
  • Organizer: JSSX-ISSX Joint Meeting
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2014-10-18 – 2014-10-23
• [Presentation] Comparison of epithelial-mesenchymal transition induced by TGF-β1 and methotrexate in human alveolar epithelial cell line A549 (2014)
  • Author(s): Kawami, M., Miyamoto, M., Yumoto, R., Takano, M.
  • Organizer: JSSX-ISSX Joint Meeting
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2014-10-18 – 2014-10-23
• [Presentation] Development of a novel stop solution for membrane transport study (2014)
  • Author(s): Hirabayashi, Y., Yumoto, R., Takano, M.
  • Organizer: JSSX-ISSX Joint Meeting
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2014-10-18 – 2014-10-23
• [Presentation] 肺胞上皮細胞の分化転換に伴うペプチドトランスポーターの発現・機能変化と喫煙関連物質の影響 (2014)
  • Author(s): 湯元良子
  • Organizer: 医療薬学ﾌｫｰﾗﾑ2014/第22回CPS
  • Place of Presentation: ビッグサイトTFTホール
  • Year and Date: 2014-06-28 – 2014-06-29
• [Presentation] 肺胞上皮細胞の分化転換と薬物輸送機能 (2014)
  • Author(s): 高野幹久、湯元 良子
  • Organizer: 日本薬剤学会第29年会
  • Place of Presentation: 大宮ソニックシティビル
  • Year and Date: 2014-05-20 – 2014-05-22
  • Invited
• [Presentation] 肺障害性薬物によるヒト由来培養肺胞上皮細胞A549の上皮間葉転換の解析 (2014)
  • Author(s): 川見昌史、山本千恵子、山口晃輝、永井純也、湯元良子、高野幹久
  • Organizer: 日本薬剤学会第29年会
  • Place of Presentation: 大宮ソニックシティビル
  • Year and Date: 2014-05-20 – 2014-05-22
• [Presentation] 生体膜トランスポーターの低温忍容性とそれを考慮した新たな輸送反応停止液の開発 (2014)
  • Author(s): 平林 悠、永井純也、湯元良子、高野幹久
  • Organizer: 日本薬剤学会第29年会
  • Place of Presentation: 大宮ソニックシティビル
  • Year and Date: 2014-05-20 – 2014-05-22
• [Presentation] 肺胞上皮細胞におけるPeptide Transporter 2の発現・機能と喫煙関連物質の影響 (2014)
  • Author(s): 佐々木佳寛、岸本海、永井純也、湯元良子、高野幹久
  • Organizer: 日本膜学会第36年会
  • Place of Presentation: 早稲田大学
  • Year and Date: 2014-05-12 – 2014-05-13
• [Presentation] Expression and function of a peptide transporter PEPT2 in alveolar epithelial cells in culture (2014)
  • Author(s): Yumoto, R., Sugimoto, N., Sasaki, Y., Yamamoto, C., Nagai, J., Ehrhardt, C., Takano, M.
  • Organizer: The 5th FIP Pharmaceutical Sciences World Congress 2014
  • Place of Presentation: Melbourne (Australia)
  • Year and Date: 2014-04-13 – 2014-04-16
• [Presentation] Multidrug-resistance modulating effects of Thai plant extracts in cancer cells (2013)
  • Author(s): Saki Kakizoe, Ryoko Yumoto, Junya Nagai, Denpong Patanasethanont, Bung-orn Sripanidkulchai, Mikihisa Takano
  • Organizer: 第７回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 東北大学片平キャンパス さくらホール
  • Year and Date: 2013-11-23 – 2013-11-24
• [Presentation] 生体膜輸送研究のための新たな輸送反応停止液の探索・開発 (2013)
  • Author(s): 平林 悠、今岡大明、永井純也、湯元良子、高野幹久
  • Organizer: 膜シンポジウム2013
  • Place of Presentation: 京都府立医科大学附属図書館ホール
  • Year and Date: 2013-11-07 – 2013-11-08
• [Presentation] 培養腎尿細管上皮細胞におけるアルブミン負荷に伴うHIF-1-alpha 発現誘導とグルコーストランスポーターの発現・機能変動の解析 (2013)
  • Author(s): 片桐祐希、永井純也、山本彩加、湯元良子、高野幹久
  • Organizer: 第52回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会
  • Place of Presentation: 松山大学 文京キャンパス
  • Year and Date: 2013-10-26 – 2013-10-27
• [Presentation] Analysis of drug-induced epithelial mesenchymal transition in cultured alveolar epithelial cell line RLE/Abca3 (2013)
  • Author(s): Chieko Yamamoto, kouki Yamaguchi, Junya Nagai, Ryoko Yumoto and Mikihisa Takano
  • Organizer: 28th JSSX Annual Meeting in Tokyo
  • Place of Presentation: Tower Hall Funabori
  • Year and Date: 2013-10-09 – 2013-10-11
• [Presentation] Effect of albumin-bound fatty acids on the expression of HIF-1-alpha and its target genes in the human renal tubular epithelial cell line HK-2 (2013)
  • Author(s): Ayaka Yamamoto, Junya Nagai, Fukuko Toshimori, Yuki Katagiri, Ryoko Yumoto and Mikihisa Takano
  • Organizer: 28th JSSX Annual Meeting in Tokyo
  • Place of Presentation: Tower Hall Funabori
  • Year and Date: 2013-10-09 – 2013-10-11
• [Presentation] Expression and function of P-glycoprotein in alveolar epithelial cells and its modulation by cigarette smoke extract (2013)
  • Author(s): Ryoko Yumoto, Yoshihiro Sasaki, Taishi Horiuchi, Yuki Kato, Umi Kishimoto, Junya Nagai, Mikihisa Takano
  • Organizer: 73th FIP World Congress
  • Place of Presentation: Convention Centre Dublin (Ireland)
  • Year and Date: 2013-08-31 – 2013-09-05
• [Presentation] 糖尿病患者における経肺投与インスリンのバイオアベイラビリティ上昇の機構解明 (2013)
  • Author(s): 西本沙央里、小田啓祐、永井純也、湯元良子、高野幹久
  • Organizer: 医療薬学フォーラム2013/第21回クリニカルファーマシーシンポジウム
  • Place of Presentation: 石川県立音楽堂・ANAクラウンプラザ金沢
  • Year and Date: 2013-07-20 – 2013-07-21
• [Presentation] 喫煙者における経肺投与インスリンのバイオアベイラビリティ上昇機構の解明 (2013)
  • Author(s): 岸本 海、佐々木佳寛、山本千恵子、堀内大士、永井純也、湯元良子、高野幹久
  • Organizer: 医療薬学フォーラム2013/第21回クリニカルファーマシーシンポジウム
  • Place of Presentation: 石川県立音楽堂・ANAクラウンプラザ金沢
  • Year and Date: 2013-07-20 – 2013-07-21
• [Presentation] 肺胞上皮細胞の上皮間葉転換と薬剤性肺傷害予測法の構築 (2013)
  • Author(s): 山口晃輝、三分一圭祐、山本千恵子、永井純也、湯元良子、高野幹久
  • Organizer: 日本薬剤学会第28年会
  • Place of Presentation: ウインクあいち
  • Year and Date: 2013-05-23 – 2013-05-25
• [Presentation] 培養腎上皮細胞におけるゲンタマイシン取り込みに及ぼすガドリニウムの影響 (2013)
  • Author(s): 田邊敬明、永井純也、澤田健史、湯元良子、高野幹久
  • Organizer: 日本薬剤学会第28年会
  • Place of Presentation: ウインクあいち
  • Year and Date: 2013-05-23 – 2013-05-25
• [Presentation] 氷冷下におけるグルコーストランスポーターの機能 (2013)
  • Author(s): 平林悠、今岡大明、永井純也、湯元良子、高野幹久
  • Organizer: 第35回日本膜学会年会
  • Place of Presentation: 早稲田大学 西早稲田キャンパス
  • Year and Date: 2013-05-20 – 2013-05-21
• [Presentation] D-グルコースによるインスリンの肺胞上皮細胞輸送の制御 (2013)
  • Author(s): 小田啓祐、湯元良子、永井純也、高野幹久
  • Organizer: 第35回日本膜学会年会
  • Place of Presentation: 早稲田大学 西早稲田キャンパス
  • Year and Date: 2013-05-20 – 2013-05-21
• [Presentation] ヒト肺がん由来細胞における5-aminolevurinic acid由来protoporphyrin IXの光毒性効果とそれに及ぼすシスプラチン耐性化の影響 (2012)
  • Author(s): 堀部紗世
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌市
  • Year and Date: 2012-03-29
• [Presentation] Mechanism underlying cytotoxic effect of the extract of Thai plant Ellipeiopsis cherrevensis in cancer cells (2012)
  • Author(s): Ryoko Yumoto
  • Organizer: 18th North American Regional ISSX Meeting
  • Place of Presentation: Hilton Anatol Hotel in Dallas （米国）
• [Presentation] タイ国産植物抽出物KP018によって誘発されるがん細胞死のメカニズム解析 (2012)
  • Author(s): 柿添 早紀
  • Organizer: 医療薬学フォーラム2012
  • Place of Presentation: 福岡国際会議場
• [Presentation] Receptor-targeted prevention of aminoglycoside accumulation and toxicity in the kidney (2011)
  • Author(s): Junya Nagai
  • Organizer: 日本薬剤学会第26年会
  • Place of Presentation: 東京都
  • Year and Date: 2011-05-31
• [Patent(Industrial Property Rights)] 特許願 (2013)
  • Inventor(s): 高野幹久 他3名
  • Industrial Property Rights Holder: 高野幹久 他3名
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-02-07