| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Outline of Final Research Achievements |
Ten extracts from Thai plants belonging to the families of Annonaceae, Rutaceae, and Zingiberaceae were obtained, in order to test anticancer effects and multidrug-resistance modulating (P-glycoprotein inhibiting) effects. The extract from Ellipeiopsis cherrevensis showed potent anticancer effects under in vitro as well as in vivo conditions, and the extract was found to induce necrosis in cancer cells. The extracts from Curcuma comosa and Kaempferia marginata showed potent P-glycoprotein inhibitory effects. These Thai plants would be a useful source to search for new anticancer drugs and multidrug-resistance modulators.
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