| Project/Area Number |
23406009
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Kentaro 長崎大学, 熱帯医学研究所, 助教 (50508885)
MIICHI Fumika 佐賀大学, 医学部, 助教 (70576818)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 赤痢アメーバ / 新生児 / 乳児 / コホート研究 / Entamoeba histolytica / Entamoeba moshkovskii / 南アジア / バングラディシュ / バングラデシュ / 国際研究者交流 / 感染症 / 下痢症 / 赤痢アメーバ症 / ゲノム疫学 |
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| Research Abstract |
In Mirpur, Dhaka, Bangladesh, natural exposure to Entamoeba spp. in infancy was prospectively observed. Approxymately, 80% of children had been infected with Entamoeba histolytica by age two years, with around 20% having suffered from E. histolytica. Furthermore, newly acquired E. moshkovskii infection was associated with diarrhea. Genetic analysis revealed that E. moshkovskii isolates infecting children were genetically heterogeneous, as evidenced by PCR typing of tRNA locus R-R. It will be important in future studies of the potential pathogenicity of E. moshkovskii to take into account this heterogeneity, as for the case of E. histolytica, not every genotype is equally capable of causing disease.
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