Research in Kenya for the development of diagnosis of latent and active tuberculosis

• Project/Area Number: 23406011
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Bacteriology (including Mycology)
• Research Institution: Niigata University (2013); Osaka City University (2011-2012)
• Principal Investigator: MATSUMOTO Sohkichi 新潟大学, 医歯学系, 教授 (30244073)
• Co-Investigator(Kenkyū-buntansha): HAMANO Shinjiro 長崎大学, 熱帯医学研究所, 教授 (70294915) ; KOBAYASHI Kazuo 国立感染症研究所, 免疫部, 部長 (20142432) ; ATO Manabu 国立感染症研究所, 免疫部, 部長 (20392318)
• Co-Investigator(Renkei-kenkyūsha): SHIMADA Masaaki 長崎大学, 熱帯医学研究所, 教授 (70124831) ; KANEKO Satoshi 長崎大学, 熱帯医学研究所, 教授 (00342907)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
• Keywords: 感染症 / 結核 / 寄生虫 / 栄養 / アフリカ / 潜在性結核 / 診断 / 活動性結核 / 免疫応答

Research Abstract

Tuberculosis is deadly infectious diseases found worldwide and remains a leading public health problem. The majority of TB cases arise from latent Mycobacterium tuberculosis infection (LTBI). However the risk of LTBI and development of TB from infection is largely unknown. We conducted comprehensive health survey in TB endemic area, Kenya Africa. In this study, 627 children from schools situated in two different sites, Mbita and Kwale districts, Kenya were enrolled. And we conducted comprehensive survey including biochemical analysis of blood and detection of infections of parasitic and bacterial pathogens. We found latent antigens M. tuberculosis is a candidates for more sensitive diagnosis of LTBI and hookworm infection is a risk of Mycobacterium tuberculosis infection besides active tuberculosis.

Research Products

• [Journal Article] Risk Factors and Spatial Distribution of Schistosoma mansoni Infection among Primary School Children in Mbita District, Western Kenya (2014)
  • Author(s): Nagi S., Chadeka E., Sunahar T., Fernando Chaves L., Mutung F., Yombo KDJ., S. Kaneko, H. Ogura, Y. Ichinose, SM. Matsumoto S., Njenga S, Hashizume M., Shimada M., Hamano S
  • Journal Title: PLOS Neg Trop Dis Volume: (in press)
  • NAID: 120006986461
  • Peer Reviewed
• [Journal Article] Direct detection of Mycobacterium avium in environmental water and scale samples by loop-mediated isothermal amplification (2014)
  • Author(s): Nishiuchi, Y., Tamaru, A., Suzuki, Y., Kitada, S., Maekura, R., Tateishi, Y., Niki, M., Ogura, H., and Matsumoto, S
  • Journal Title: J Water Health Volume: (in press)
  • Peer Reviewed
• [Journal Article] Relationship between Mycobacterium tuberculosis and hookworm infections among school children in Mbita, Kenya (2014)
  • Author(s): Manabu I, Nagi S., Chadeka E., Mutungi F., Osada-Oka M., Ono K., Oda T., Michinori T., Ozeki Y., Dan Justin Yombo K., Okabe M., Niki M., Hirayama Y., Fukui M., Kobayashi K., M. Matsumoto, M. Shimada, S. Kaneko, H. Ogura, Y. Ichinose, SM. Njenga, S. Hamano, and S. Matsumoto
  • Journal Title: J Trop Dis Volume: (in press)
  • Peer Reviewed
• [Journal Article] 結核とその制圧を目指した研究 (2014)
  • Author(s): 松本壮吉
  • Journal Title: 新潟医学会誌 Volume: 766 Pages: 2-7
• [Journal Article] Multicolor Flow Cytometric Analyses of CD4(+) T Cell Responses to Mycobacterium tuberculosis-Related Latent Antigens (2013)
  • Author(s): Yamashita, Y., Y. Hoshino, M. Oka, S. Matsumoto, H. Ariga, H. Nagai, M. Makino, K. Ariyoshi, and Y. Tsunetsugu-Yokota
  • Journal Title: Jpn J Infect Dis Volume: 66 Pages: 207-215
  • NAID: 130003381673
  • Peer Reviewed
• [Journal Article] Whole-Genome Sequence of the Potentially Hypertransmissible Multidrug-Resistant Mycobacterium tuberculosis Beijing Strain OM-V02_005 (2013)
  • Author(s): Tateishi, Y., A. Tamaru, Y. Ogura, M. Niki, T. Wada, T. Yamamoto, K. Hirata, T. Hayashi, and S. Matsumoto
  • Journal Title: Genome Announc Volume: 1
  • Peer Reviewed
• [Journal Article] Reactivation of immune responses against Mycobacterium tuberculosis by boosting with the CpG oligomer in aged mice primarily vaccinated with Mycobacterium bovis BCG (2013)
  • Author(s): Taniguchi, K., T. Takii, S. Yamamoto, J. Maeyama, S. Iho, M. Maruyama, N. Iizuka, Y. Ozeki, S. Matsumoto, T. Hasegawa, Y. Miyatake, S. Itoh, and K. Onozaki
  • Journal Title: Immun Ageing Volume: 10 Pages: 25-25
  • Peer Reviewed
• [Journal Article] Antigen 85A and mycobacterial DNA-binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis (2013)
  • Author(s): Osada-Oka, M., Y. Tateishi, Y. Hirayama, Y. Ozeki, M. Niki, S. Kitada, R. Maekura, K. Tsujimura, Y. Koide, N. Ohara, T. Yamamoto, K. Kobayashi, and S. Matsumoto
  • Journal Title: Microbiol Immunol Volume: 57 Pages: 30-37
  • Peer Reviewed
• [Journal Article] 鉄代謝およびイソニアジド耐性にかかわる結核菌分子の機能と治療法開発の可能性 (2013)
  • Author(s): 仁木満美子, 松本壮吉
  • Journal Title: 化学療法の領域 Volume: Vol29 2号 Pages: 119-124
• [Journal Article] 潜在性結核と結核菌の潜伏感染メカニズム (2013)
  • Author(s): 松本壮吉
  • Journal Title: 医学のあゆみ Volume: 246 Pages: 470-473
• [Journal Article] 抗酸菌の休眠現象や薬剤抵抗性に関わる分子メカニズム (2013)
  • Author(s): 松本壮吉
  • Journal Title: Jpn. J. Lepr Volume: 82 Pages: 119-122
• [Journal Article] Critical roles for lipomannan and lipoarabinomannan in cell wall integrity of mycobacteria and pathogenesis of tuberculosis (2013)
  • Author(s): Fukuda, T., T. Matsumura, M. Ato, M. Hamasaki, Y. Nishiuchi, Y. Murakami, Y. Maeda, T. Yoshimori, S. Matsumoto, K. Kobayashi, T. Kinoshita, and Y. S. Morita
  • Journal Title: Mbio Volume: 4
  • Peer Reviewed
• [Journal Article] Whole-Genome Sequence of the Potentially Hypertransmissible Multidrug-Resistant Mycobacterium tuberculosis Beijing Strain OM-V02_005 (2013)
  • Author(s): Y. Tateishi A. Tamaru Y. Ogura M. Niki T. Wada T. Yamamoto K. Hirata T. Hayashi S. Matsumoto.
  • Journal Title: Genome Announc Volume: 1 Pages: 8-13
  • Peer Reviewed
• [Journal Article] Reactivation of immune responses against Mycobacterium tuberculosis by boosting with the CpG oligomer in aged mice primarily vaccinated with Mycobacterium bovis BCG (2013)
  • Author(s): K. Taniguchi T. Takii S. Yamamoto J. Maeyama S. Iho M. Maruyama N. Iizuka Y. Ozeki S. Matsumoto T. Hasegawa Y. Miyatake S. Itoh K. Onozaki.
  • Journal Title: Immun Ageing Volume: 10 Pages: 25-25
  • Peer Reviewed
• [Journal Article] Antigen 85A and mycobacterial DNA-binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis (2013)
  • Author(s): M. Osada-Oka Y. Tateishi Y. Hirayama Y. Ozeki M. Niki, S. Kitada R. Maekura K. Tsujimura Y. Koide N. Ohara T. Yamamoto K. Kobayashi S. Matsumoto.
  • Journal Title: Microbiol Immuno Volume: 57 Pages: 30-37
  • Peer Reviewed
• [Journal Article] Critical roles for lipomannan and lipoarabinomannan in cell wall integrity of mycobacteria and pathogenesis of tuberculosis (2013)
  • Author(s): T. Fukuda T. Matsumura M. Ato M. Hamasaki Y. Nishiuchi, Y. Murakami Y. Maeda, T. Yoshimori, S.Matsumoto, K. Kobayashi T. Kinoshita Y. S. Morita.
  • Journal Title: MBio Volume: 4 Pages: 412-472
  • Peer Reviewed
• [Journal Article] 鉄代謝およびイソニアジド耐性にかかわる結核菌分子の機能と治療法開発の可能性 (2013)
  • Author(s): 仁木 満美子 松本 壮吉
  • Journal Title: 化学療法の領域 Volume: 29 Pages: 119-124
  • Peer Reviewed
• [Journal Article] 抗酸菌の休眠現象や薬剤抵抗性に関わる分子メカニズム (2013)
  • Author(s): 松本 壮吉
  • Journal Title: Jpn. J. Lepr. Volume: 82 Pages: 119-122
  • Peer Reviewed
• [Journal Article] Multicolor flow cytometric analyses of CD4+ T cell responses to Mycobacterium tuberculosis-related latent antigens. Jap J Infect Dis, (2013)
  • Author(s): Yamashita, Y., Y. Hoshino, M. Osada-Oka, S. Matsumoto, H. Ariga, H. Nagai, M. Makino, K. Ariyoshi, and Y. Tsunetsugu-Yokota.
  • Journal Title: Japanese Journal of Infectious Diseases Volume: 印刷中の為未確定
  • Peer Reviewed
• [Journal Article] Antigen 85A and mycobacterial DNA-binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis. (2013)
  • Author(s): Osada-Oka, M., Y. Tateishi, Y. Hirayama, Y. Ozeki, M. Niki, S. Kitada, R. Maekura, K. Tsujimura, Y. Koide, N. Ohara, T. Yamamoto, K. Kobayashi, and S. Matsumoto.
  • Journal Title: Microbiology and Immunology Volume: 57 Pages: 30-37
  • Peer Reviewed
• [Journal Article] Critical roles for lipomannan and lipoarabinomannan in cell wall integrity of mycobacteria and pathogenesis of tuberculosis. (2013)
  • Author(s): Fukuda T, Matsumura T, Ato M, Hamasaki M, Nishiuchi Y, Murakami Y, Maeda Y, Yoshimori T, Matsumoto S, Kobayashi K, Kinoshita T, Morita Y.
  • Journal Title: MBio Volume: 4 Issue: 1
  • DOI: 10.1128/mbio.00472-12
  • Peer Reviewed
• [Journal Article] Whole-Genome Sequence of the Hypervirulent Clinical Strain Mycobacterium intracellulare M.i.198 (2012)
  • Author(s): Tateishi, Y., S. Kitada, K. Miki, R. Maekura, Y. Ogura, Y. Ozeki, Y. Nishiuchi, M. Niki, T. Hayashi, K. Hirata, K. Kobayashi, and S. Matsumoto
  • Journal Title: J Bacteriol Volume: 194 Pages: 6336-6336
  • Peer Reviewed
• [Journal Article] Dominant Incidence of Multidrug and Extensively Drug-Resistant Specific Mycobacterium tuberculosis Clones in Osaka Prefecture, Japan (2012)
  • Author(s): Tamaru, A., C. Nakajima, T. Wada, Y. Wang, M. Inoue, R. Kawahara, R. Maekura, Y. Ozeki, H. Ogura, K. Kobayashi, Y. Suzuki, and S. Matsumoto
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Journal Article] A novel mechanism of growth phase-dependent tolerance to isoniazid in mycobacteria (2012)
  • Author(s): Niki, M., M. Niki, Y. Tateishi, Y. Ozeki, T. Kirikae, A. Lewin, Y. Inoue, M. Matsumoto, J. L. Dahl, H. Ogura, K. Kobayashi, and S. Matsumoto
  • Journal Title: J Biol Chem Volume: 287 Pages: 27743-27752
  • Peer Reviewed
• [Journal Article] Protection by a Recombinant Mycobacterium bovis Bacillus Calmette-Guerin Vaccine Expressing Shiga Toxin 2 B Subunit against Shiga Toxin-Producing Escherichia coli in Mice (2012)
  • Author(s): Fujii, J., M. Naito, T. Yutsudo, S. Matsumoto, D. P. Heatherly, T. Yamada, H. Kobayashi, S. Yoshida, and T. Obrig
  • Journal Title: Clin Vaccine Immunol Volume: 19 Pages: 1932-1937
  • Peer Reviewed
• [Journal Article] 新しい結核ワクチ開発の展望 (2012)
  • Author(s): 松本壮吉, 尾関百合子, 小林和夫
  • Journal Title: 臨床と微生物 Volume: Vol39 2号 Pages: 131-136
• [Journal Article] Whole-Genome Sequence of the Hypervirulent Clinical Strain Mycobacterium intracellulare M.i.198. (2012)
  • Author(s): Tateishi, Y., S. Kitada, K. Miki, R. Maekura, Y. Ogura, Y. Ozeki, Y. Nishiuchi, M. Niki, T. Hayashi, K. Hirata, K. Kobayashi, and S. Matsumoto.
  • Journal Title: Journal of Bacteriology Volume: 194 Issue: 22 Pages: 6336-6336
  • DOI: 10.1128/jb.01439-12
  • Peer Reviewed
• [Journal Article] Dominant Incidence of Multidrug and Extensively Drug-Resistant Specific Mycobacterium tuberculosis Clones in Osaka Prefecture, Japan. (2012)
  • Author(s): Tamaru, A., C. Nakajima, T. Wada, Y. Wang, M. Inoue, R. Kawahara, R. Maekura, Y. Ozeki, H. Ogura, K. Kobayashi, Y. Suzuki, and S. Matsumoto.
  • Journal Title: PLoS One Volume: 7 Issue: 8 Pages: e42505-e42505
  • DOI: 10.1371/journal.pone.0042505
  • Peer Reviewed
• [Journal Article] A novel mechanism of growth phase-dependent tolerance to isoniazid in mycobacteria. (2012)
  • Author(s): Niki M, Niki M, Tateishi Y, Ozeki Y, Kirikae T, Lewin A, Inoue Y, Matsumoto M, Dahl JL, Ogura H, Kobayashi K, Matsumoto S
  • Journal Title: J Biol Chem Volume: 287(33) Issue: 33 Pages: 27743-52
  • DOI: 10.1074/jbc.m111.333385
  • Peer Reviewed
• [Journal Article] A Histone-Like Protein of Mycobacteria Possesses Ferritin Superfamily Protein-Like Activity and Protects against DNA Damage by Fenton Reaction (2011)
  • Author(s): Takatsuka, M., M. Osada-Oka, E.F. Satoh, K. Kitadokoro, Y. Nishiuchi, M. Niki, M. Inoue, K. Iwai, T. Arakawa, Y. Shimoji, H. Ogura, K. Kobayashi, A. Rambukkana, and S. Matsumoto
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed
• [Journal Article] Loss of anti-mycobacterial efficacy in mice over time following vaccination with Mycobacterium bovis bacillus Calmette-Guerin (2011)
  • Author(s): Ozeki, Y., Y. Hirayama, T. Takii, S. Yamamoto, K. Kobayashi, and S. Matsumoto
  • Journal Title: Vaccine Volume: 29 Pages: 6881-6887
  • Peer Reviewed
• [Journal Article] Mitochondrial density contributes to the immune response of macrophages to lipopolysaccharide via the MAPK pathway (2011)
  • Author(s): Kasahara, E., A. Sekiyama, M. Hori, K. Hara, N. Takahashi, M. Konishi, E. F. Sato, S. Matsumoto, H. Okamura, and M. Inoue
  • Journal Title: FEBS Lett Volume: 585 Pages: 2263-2268
  • Peer Reviewed
• [Journal Article] Global threats and the control of multidrug-resistant tuberculosis (2011)
  • Author(s): Kobayashi, K., M. Ato, and S. Matsumoto
  • Journal Title: J. Disaster Res Volume: 6 Pages: 443-450
  • Peer Reviewed
• [Journal Article] 結核研究の新たな展開-潜在性結核と結核菌 : 休眠現象の分子メカニズムー (2011)
  • Author(s): 仁木満美子, 仁木誠, 尾関百合子, 岡真優子, 松本壮吉
  • Journal Title: 最新医学 Volume: Vol66 3号 Pages: 149-15
• [Journal Article] A Histone-Like Protein of Mycobacteria Possesses Ferritin Superfamily Protein-Like Activity and Protects against DNA Damage by Fenton Reaction (2011)
  • Author(s): Takatsuka, M., M.Osada-Oka, E.F.Satoh, K.Kitadokoro, Y.Nishiuchi, M.Niki, M.Inoue, K.Iwai, T.Arakawa, Y.Shimoji, H.Ogura, K.Kobayashi, A.Rambukkana, S.Matsumoto
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed
• [Journal Article] 結核菌の病原性および増殖制御機構の分子遺伝学的解析と応用研究 (2011)
  • Author(s): 松本壮吉
  • Journal Title: 日本細菌学会誌 Volume: Vol664号 Pages: 531-537
  • NAID: 10030278737
• [Presentation] Mycobacterium avium Infects Human Erythrocytes in vitro. US-Japan Cooperative Medical Science Program (2013)
  • Author(s): Nishiuchi, Y. and S. Matsumoto
  • Organizer: Tuberculosis and Leprosy Panel Meeting in Japan
  • Place of Presentation: Sapporo, Japan
• [Presentation] Ferritin superfamily protein-like activity in mycobacterial DNA-binding protein 1 (2013)
  • Author(s): Osada-Oka, M., S. Matsumoto, Y. Ozeki, Y. Minamiyama
  • Organizer: 6th Joint Meeting of The Societies for Free Radical Research Australasia and Japan
  • Place of Presentation: Sydney, Australia
• [Presentation] 抗酸菌の潜伏感染や薬剤抵抗性に関わる分子メカニズム (2013)
  • Author(s): 松本壮吉
  • Organizer: 第86回日本ハンセン病学会総会・学術大会
  • Place of Presentation: さいたま市
• [Presentation] 結核菌感染に対するマクロファージの生体防御機構 (2013)
  • Author(s): 岡真優子, 松本壮吉, 尾関百合子, 市川寛, 南山幸子
  • Organizer: 第66回日本酸化ストレス学会
  • Place of Presentation: 名古屋市
• [Presentation] 宿主細胞内で増殖する結核菌のエネルギー産生と増殖機構 (2013)
  • Author(s): 岡真優子, 松本壮吉, 尾関百合子, 南山幸子
  • Organizer: 第7回細菌学若手コロッセウム
  • Place of Presentation: 広島県三原市
• [Presentation] 結核ブースターワクチンとしての結核菌組換え蛋白MDP1 および TLR9 リガンド G9.1 アジュバントの結核菌噴霧感染による評価 (2013)
  • Author(s): 前山順一 , 山崎利雄 , 山本十糸子, 林大介 , 松本壮吉, 網康至 , 伊保澄子, 山本三郎
  • Organizer: 第17回日本ワクチン学会学術集会
  • Place of Presentation: 津市
• [Presentation] BCG ワクチン接種が原因と思われる骨髄炎の幼児 (2013)
  • Author(s): 戸田彩季, 瀬戸俊之, 時政定雄, 新宅治夫, 松本壮吉
  • Organizer: 第54回日本熱帯医学会大会
  • Place of Presentation: 長崎市
• [Presentation] ケニア共和国Mbita 地区の児童における結核菌感染と鉤虫感染の関連 (2013)
  • Author(s): 井上学, 岡真優子, 仁木満美子, 尾関百合子, 一瀬休生, 濱野真二郎, 松本壮吉
  • Organizer: 第54回日本熱帯医学会大会
  • Place of Presentation: 長崎市
• [Presentation] 潜在性結核のバイオマーカーとしての抗Antigen85 およびMycobacteri DNA-binding protein 1 抗体 (2013)
  • Author(s): 岡真優子, 立石善隆, 平山幸雄, 尾関百合子, 前倉亮次, 小林和夫, 松本壮吉
  • Organizer: 第54回日本熱帯医学会大会
  • Place of Presentation: 長崎市
• [Presentation] Ferritin superfamily protein-like activity in mycobacterial DNA-binding protein 1. (2013)
  • Author(s): Osada-Oka,M., S. Matsumoto, Y. Ozeki, Y. Minamiyama.
  • Organizer: 6th Joint Meeting of The Societies for Free Radical Research Australasia and Japan.
  • Place of Presentation: Sydney, Australia
• [Presentation] 結核ブースターワクチンとしての結核菌組換えタンパMDP1 およびTLR9 リガントG9.1 アジュバントの結核菌噴霧感染による評価 (2013)
  • Author(s): 前山 順一 、山崎 利雄 、山本 十糸子、林 大介 、松本 壮吉、網 康至 、 伊保 澄子、山本 三郎
  • Organizer: 第17回日本ワクチン学会学術集会
  • Place of Presentation: 津市
• [Presentation] BCGワクチン接種が原因と思われる骨髄炎の幼児 (2013)
  • Author(s): 戸田 彩季、瀬戸 俊之、時政 定雄、新宅 治夫、松本 壮吉
  • Organizer: 第54回日本熱帯医学会大会
  • Place of Presentation: 長崎市
• [Presentation] ケニア共和国Mbita地区の児童における結核菌感染と鉤虫感染の関連 (2013)
  • Author(s): 井上 学、岡 真優子、仁木 満美子、尾関 百合子、一瀬 休生、濱野 真二郎、松本 壮吉
  • Organizer: 第54回日本熱帯医学会大会
  • Place of Presentation: 長崎市
• [Presentation] 潜在性結核のバイオマーカーとしての抗Antigen85およびMycobacteri DNA-binding protein 1抗体 (2013)
  • Author(s): 岡 真優子、立石 善隆、平山 幸雄、尾関 百合子、前倉 亮次、小林 和夫、松本 壮吉
  • Organizer: 第54回日本熱帯医学会大会
  • Place of Presentation: 長崎市
• [Presentation] 環境分離抗酸菌のバイオフィルム形成因子の検討 (2013)
  • Author(s): 松本 壮吉
  • Organizer: 第８６回 日本細菌学会総会
  • Place of Presentation: 幕張メッセ 国際会議場
• [Presentation] BCG Tokyo172株のサブポピュレーションBCG-IIを用いた結核ブースターワクチン候補の評価 (2013)
  • Author(s): 松本 壮吉
  • Organizer: 第８６回 日本細菌学会総会
  • Place of Presentation: 幕張メッセ 国際会議場
• [Presentation] ケニア共和国における学生の結核菌感染とhookworm感染の関連 (2013)
  • Author(s): 松本 壮吉
  • Organizer: 第８６回 日本細菌学会総会
  • Place of Presentation: 幕張メッセ 国際会議場
• [Presentation] 高病原性非結核性抗酸菌臨床菌株のゲノムシーケンス (2013)
  • Author(s): 松本 壮吉
  • Organizer: 第８６回 日本細菌学会総会
  • Place of Presentation: 幕張メッセ 国際会議場
• [Presentation] リコンビナントBCG(rBCG)を用いた迅速スクリーニング法による抗結核薬の探索と同定 (2013)
  • Author(s): 松本 壮吉
  • Organizer: 第８６回 日本細菌学会総会
  • Place of Presentation: 幕張メッセ 国際会議場
• [Presentation] 潜在性結核患者の血清中での結核菌抗原に対するイムノグロブリンg (2013)
  • Author(s): 松本 壮吉
  • Organizer: 第８６回 日本細菌学会総会
  • Place of Presentation: 幕張メッセ 国際会議場
• [Presentation] 休止期結核菌の性状と, 休止期抗原を利用した結核菌感染検出の試み (2012)
  • Author(s): 松本壮吉
  • Organizer: 第44回関西抗酸菌研究会
  • Place of Presentation: 大阪
  • Year and Date: 2012-08-24
• [Presentation] 非結核性抗酸菌が形成するバイオフィルムの生態学的特徴 (2012)
  • Author(s): 西内由紀子, 戸谷孝洋, 立石善隆, 前倉亮治, 松本壮吉
  • Organizer: 第26回Bacterial Adherence & Biofilm学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2012-07-13
• [Presentation] 結核菌の増殖, 長期生存, および静止期以降の薬剤抵抗性獲得の分子メカニズム (2012)
  • Author(s): 松本壮吉
  • Organizer: 第26回Bacterial Adherence & Biofilm 学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2012-07-13
• [Presentation] 結核菌の休眠現象と潜在性結核診断の可能性 (2012)
  • Author(s): 松本壮吉
  • Organizer: 第2回結核感染診断研究会
  • Place of Presentation: 広島
  • Year and Date: 2012-05-09
• [Presentation] 定常期抗酸菌にみられるイソニアジド抵抗性獲得メカニズムの解析 (2012)
  • Author(s): 仁木満美子, 松本壮吉
  • Organizer: 第82回実験結核研究会
  • Place of Presentation: 広島
  • Year and Date: 2012-05-09
• [Presentation] Recovery and genetic polymorphism of Mycobacterium avium complex (MAC) in the Bathroom (2012)
  • Author(s): Nishiuchi Y., S. Kitada, S. Matsumoto, and R. Maekura
  • Organizer: Tuberculosis 2012
  • Place of Presentation: Paris, France
• [Presentation] ケニア共和国における, 学生の潜在性結核菌感染と様々な寄生虫感染 (2012)
  • Author(s): Inoue M., S. Nagi, E. Faith, M. Osada-Oka, K. Ono, Y. Ozeki, M. Niki, K. Kobayashi, M. Matsumoto, M. Shimada, S. Kaneko, Y. Ichinose, S. Njenga, S. Hamano, and S. Matsumoto
  • Organizer: 第53回日本熱帯医学会大会
  • Place of Presentation: 北海道
• [Presentation] Functions of mycobacterial DNA binding protein and its contribution to the persistent infection of Mycobacterium tuberculosis (2012)
  • Author(s): Matsumoto S
  • Organizer: The 11th Korea-Japan International Symposium on Microbiology
  • Place of Presentation: Buyeo, Korea
• [Presentation] 結核ブースターワクチンとしての結核菌組換えタンパク質およびアジュバントの評価 (2012)
  • Author(s): 前山順一, 伊保澄子, 岡真優子, 松本壮吉, 山本三郎
  • Organizer: 第16回日本ワクチン学会学術集会
  • Place of Presentation: 神奈川
• [Presentation] Loss of anti-mycobacterial efficacy in mice over time following vaccination with Mycobacterium bovis bacillus Calmette-Guerin (2011)
  • Author(s): Yuriko Ozeki, Yukio Hirayama, Osada-Oka mayuko, Takemasa Takii, Saburo Yamamoto, Kazuo Kobayashi, and Sohkichi Matsumoto
  • Organizer: 第64回日本細菌学会関西支部総会
  • Place of Presentation: 大阪
  • Year and Date: 2011-11-19
• [Presentation] マクロファージ内結核菌増殖における宿主グルコース代謝の重要性 (2011)
  • Author(s): 岡真優子, 合田亘人, 曽我朋義, 尾関百合子, 小林和夫, 松本壮吉, 岩尾洋
  • Organizer: 第64回日本細菌学会関西支部総会
  • Place of Presentation: 大阪
  • Year and Date: 2011-11-19
• [Presentation] 結核菌の増殖制御機構と結核制圧戦略 (2011)
  • Author(s): 松本壮吉
  • Organizer: 第7回霊長類医科学フォーラム
  • Place of Presentation: 茨城
  • Year and Date: 2011-11-18
• [Presentation] 結核菌の増殖制御機構と結核制圧戦略 (2011)
  • Author(s): 松本壮吉
  • Organizer: 第7回霊長類医科学フォーラム
  • Place of Presentation: 茨城(招待講演)
  • Year and Date: 2011-11-18
• [Presentation] 結核血清診断の進歩 (2011)
  • Author(s): 立石善隆, 北田清悟, 前倉亮治, 松本壮吉
  • Organizer: 第86回日本結核病学会総会
  • Place of Presentation: 東京
• [Presentation] 抗酸菌の薬剤感受性におけるヒストン様蛋白質の機能解析 (2011)
  • Author(s): 仁木誠, 仁木満美子, 松本壮吉
  • Organizer: 第86回日本結核病学会総会
  • Place of Presentation: 東京
• [Presentation] HOST FACTORS HAVING AN IMPACT ON THE GROWTH OF MYCOBACTERIUM TUBERCULOSIS (2011)
  • Author(s): Sohkichi Matsumoto
  • Organizer: International Union Microbiological Societies 2011 Congress
  • Place of Presentation: Sapporo, Japan
• [Presentation] BIOFILM FORMATION OF MYCOBACTERIUM AVIUM ISOLATED FROM LIVING ENVIRONMENT (2011)
  • Author(s): Yukiko Nishiuchi, Sohkichi Matsumoto, Yoshitaka Tateishi, Nobuyasu Yamaguchi, Masao Nasu
  • Organizer: International Union Microbiological Societies 2011 Congress
  • Place of Presentation: Sapporo, Japan
• [Presentation] IMMUNE RESPONSES IN GUINEA PIG ADMINISTERED WITH ANTI-TUBERCULOSIS BOOSTER VACCINE CANDIDATE (2011)
  • Author(s): Jun-Ichi Maeyama, Sumiko Iho, Mayuko Osada-Oka, Sohkichi Matsumoto, Masanori Isaka, Sabuso Yamamoto
  • Organizer: International Union Microbiological Societies 2011 Congress
  • Place of Presentation: Sapporo, Japan
• [Presentation] THE EFFICACY OF BCG MAY BE A TIME-DEPENDENT AFTER THE VACCINATION AND AGE-INDEPENDENT IN MICE (2011)
  • Author(s): Yuriko Ozeki, Kazuo Kobayashi, Sohkichi Matsumoto
  • Organizer: International Union Microbiological Societies 2011 Congress
  • Place of Presentation: Sapporo, Japan
• [Presentation] 結核菌の休眠現象と潜在性結核 (2011)
  • Author(s): 松本壮吉, 小林和夫
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
• [Presentation] 結核菌がゆっくりと長く生きるメカニズムと結核の制圧を目指した研究 (2011)
  • Author(s): 松本壮吉
  • Organizer: 第52回日本熱帯医学会大会・第26回日本国際保健医療学会学術大会
  • Place of Presentation: 東京
• [Presentation] 潜在性結核の分子機構と結核制圧研究 (2011)
  • Author(s): 松本壮吉
  • Organizer: 第28回日本医学会総会
  • Place of Presentation: 東京(招待講演)
• [Presentation] HOST FACTORS HAVING AN IMPACT ON THE GROWTH OF MYCOBACTERIUM (2011)
  • Author(s): Sohkichi Matsumoto
  • Organizer: Union Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌(招待講演)
• [Presentation] 結核菌の休眠現象と潜在性結核 (2011)
  • Author(s): 松本壮吉
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都(招待講演)
• [Presentation] 結核菌がゆっくりと長く生きるメカニズムと結核の制圧を目指した研究 (2011)
  • Author(s): 松本壮吉
  • Organizer: 第52回日本熱帯医学会大会第26回日本国際保健医療学会学術大会
  • Place of Presentation: 東京(招待講演)
• [Presentation] 結核菌の休眠現象と潜在性結核診断の可能性
  • Author(s): 松本 壮吉
  • Organizer: 第２回結核感染診断研究会
  • Place of Presentation: 広島
  • Invited
• [Presentation] 結核菌の増殖、長期生存、および静止期以降の薬剤抵抗性獲得の分子メカニズム
  • Author(s): 松本 壮吉
  • Organizer: 第26回 Bacterial Adherence & Biofilm学術集会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 休止期結核菌の性状と、休止期抗原を利用した結核菌感染検出の試み
  • Author(s): 松本 壮吉
  • Organizer: 第44回関西抗酸菌研究会
  • Place of Presentation: 大阪
  • Invited
• [Book] 人獣共通感染症, 非結核性抗酸菌症改訂版 (2011)
  • Author(s): 西内由紀子, 立石善隆, 山田毅, 松本壮吉症, 木村哲, 喜田宏編集
  • Publisher: 医薬ジャーナル社
• [Book] Host and bacterial factors that regulate Mycobacterium tuberculosis infection and persistence, BCG vaccine and adjuvant (2011)
  • Author(s): Niki M and Matsumoto S, Yamamoto S, Maeyama J, and Takii T editors
  • Publisher: Japan anti-tuberculosis association, Tokyo
• [Book] 非結核性抗酸菌症改訂版 (2011)
  • Author(s): 西内由紀子、立石善隆、山田毅、松本壮吉、人獣共通感染症、木村哲、喜田宏編集
  • Total Pages: 5
  • Publisher: 医薬ジャーナル社
• [Book] BCG vaccine and adjuvant (2011)
  • Author(s): Mamiko Niki, Shokichi Matsumoto, Host and bacterial factors that regulate Mycobacterium tuberculosis infection and persistence, Yamamoto S, Maeyama J, Takii T editors
  • Total Pages: 23
  • Publisher: Anti-Tuberculosis Association
• [Remarks] 細菌学
  • URL: http://www.med.niigata-u.ac.jp/contents/summary/index.html