| Project/Area Number |
23406012
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Chiba Institute of Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKADA Nobuhiro 福井大学, 医学部, シニアフェロー (90003409)
OHASHI Norio 静岡県立大学, 食品栄養学部, 教授 (10169039)
KADOSAKA Teruki 愛知医科大学, 医学部, 講師 (90109760)
OIKAWA Yosaburo 金沢医科大学, 医学部, 医学部 (10139785)
NATSUAKI Masaru 兵庫医科大学, 医学部, 准教授 (60208072)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | アナプラズマ / ヒト顆粒球アナプラズマ症 / ボレリア / ライム病 / ダニ媒介性感染症 / シュルツェマダニ / 紅斑熱 / マダニ / マダニ媒介性感染症 / リケッチア |
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| Research Abstract |
The prevalence of human granulocytic anaplasmosis (HGA) agent, Anaplasma phagocytophilum and relapsing fever agent, Borrelia miyamotoi, in reservoir animals and vector ticks in East Asia, including Japan, were examined. Anaplasma was detected from Ixodes persulcatus ticks collected in Irkutsk, Khabarovsk, and Selenge in Mongolia. In Kochi Prefecture, Japan, two patients were confirmed retrospectively to be infected with Anaplasma and the agent detected was similar to those from ticks collected in far-east Russia. Relapsing fever-causing Borrelia was detected in ticks collected in Irkutsk and Khabarovsk, indicating that relapsing fever should be involved in the diagnosis of tick bite patients. Variant Anaplasma was detected in wild rodents captured in Taiwan. This agent has not been found in ticks collected in Taiwan and also China.
Polysaccharide antigen extracted from spotted fever Rickettsia under alkaline condition could be used as antigen for Dot-ELISA-based serodiagnosis.
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