| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Outline of Final Research Achievements |
countries. Post-exposure vaccination in human and mass vaccination of dogs is the most rational strategy for reducing rabies victims or interrupting the natural transmission cycle of rabies. To know viral neutralizing antibody (VNA) level against rabies virus rapidly and easily is essential not only for evaluating protective immunity of humans and dogs but also for strategy for eradication program. Our newly developed RAPINA is a method which can determine the VNA easily, rapidly, and low-cost.We reported the performance of the RAPINA for evaluating vaccination status of the humans and dogs by multicenter comparison in Asia. Compared to the VNA level determined by standard neutralizing test, positive and negative predicted values and concordance ratio of RAPINA were highly homologous and reproducible among different laboratories. We concluded that the RAPINA will be effective tool for monitoring vaccination coverage in resource-limited countries.
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