• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Reproductive and developmental effects of lead and other trace metals:international collaboration studies between Japan, China, Indonesia, and Iran

Research Project

Project/Area Number 23406024
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene and public health
Research InstitutionJuntendo University

Principal Investigator

YOKOYAMA Kazuhito  順天堂大学, 医学部, 教授 (00158370)

Co-Investigator(Kenkyū-buntansha) TAKEDA Satoru  順天堂大学, 医学部, 教授 (20143456)
SHIMIZU Toshiaki  順天堂大学, 医学部, 教授 (30260889)
CHIBA Momoko  順天堂大学, 医学部, 客員教授 (80095819)
SHINOHARA Atsuko  清泉女子大学, 人文科学研究所, 教授 (90157850)
VIEGH Mohsen  労働安全衛生総合研究所, 研究員 (80455485)
Co-Investigator(Renkei-kenkyūsha) NISHIOKA Emiko  防衛医科大学, 看護学部, 教授 (70550797)
KITAMURA Fumihiko  順天堂大学, 医学部, 准教授 (20301145)
HOSOKAWA Mayuko  順天堂大学, 医学部, 助教 (70582013)
MATSUKAWA Takehisa  順天堂大学, 医学部, 助教 (60453586)
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords小児 / 微量元素 / 環境 / 健康影響 / 衛生 / 開発途上国 / 有害微量元素 / 非顕性影響
Outline of Final Research Achievements

We have conducted epidemiological surveys on the reproductive and developmental effects of lead and other trace metals in Tehran, Dalian, Serpong and Tokyo. The survey in Tehran, we revealed that a relatively low level of prenatal lead exposure (mean < 6.5 micro-g/dL) associated with lower developmental scores in early childhood. The survey in Dalian revealed that newborn birth weight were affected by manganese concentration in mother whole blood and/or umbilical cord blood. The survey in Serpong revealed that lower socioeconomic status were associated with increased blood lead concentrations, especially in female children. The survey in Tokyo suggested that very low-level exposure to lead ( < 5.0 micro-g/dL) in early gestation could be a risk factor for reduced birth weight in male offspring. Lead, manganese and other metals may cause adverse reproductive and developmental effects at levels believed to be safe.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (21 results)

All 2015 2014 2013 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Acknowledgement Compliant: 2 results) Presentation (13 results)

  • [Journal Article] The relation of maternal blood arsenic to anemia during pregnancy.2015

    • Author(s)
      Vigeh M., Yokoyama K., Matsukawa T., Shinohara A., Ohtani K.
    • Journal Title

      Women&Health

      Volume: 55 Issue: 1 Pages: 42-57

    • DOI

      10.1080/03630242.2014.972016

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Low level prenatal blood lead adversely affects early childhood mental development.2014

    • Author(s)
      Vigeh M., Yokoyama K., Matsukawa T., Shinohara A., Ohtani K
    • Journal Title

      Journal of Child Neurology

      Volume: 29 Issue: 10 Pages: 1305-1311

    • DOI

      10.1177/0883073813516999

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence that birth weight is decreased by maternal lead levels below 5μg/dl in male newborns.2014

    • Author(s)
      Nishioka E., Yokoyama K., Matsukawa T., Vigeh M., Hirayama S., Ueno T., Miida T., Makino S., Takeda S.
    • Journal Title

      Reproductive Toxicology

      Volume: 47 Pages: 21-26

    • DOI

      10.1016/j.reprotox.2014.05.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Manganese concentrations in maternal and umbilical cord blood: related to birth size and environmental factors.2014

    • Author(s)
      Guan H., Wang M., Li X., Piao F., Li Q., Xu L., Kitamura F., Yokoyama K
    • Journal Title

      The European Journal of Public Health

      Volume: 24 Pages: 150-157

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increase in blood manganese induces gestational hypertension during pregnancy. Hypertension in pregnancy2013

    • Author(s)
      Vigeh M., Yokoyama K., Ohtani K., Shahbazi F., Matsukawa T
    • Journal Title

      Journal of the International Society for the Study of Hypertension in Pregnancy

      Volume: 32 Pages: 214-224

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross-sectional study on the effects of socioeconomic factors on lead exposure in children by gender in Serpong, Indonesia.2012

    • Author(s)
      Iriani UD, Matsukawa T, Tadjudin KM, Itoh H, Yokoyama K.
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 9 Issue: 11 Pages: 4135-4149

    • DOI

      10.3390/ijerph9114135

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal exposure to arsenic and its effects on fetal development in the general population of Dalian.2012

    • Author(s)
      Guan H, Piao F, Zhang X, Li X, Li Q, Xu L, Kitamura F, Yokoyama K
    • Journal Title

      Biological Trace Element Research.

      Volume: 149 Issue: 1 Pages: 10-15

    • DOI

      10.1007/s12011-012-9396-7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood lead at currently acceptable levels may cause preterm labor2011

    • Author(s)
      Mohsen Vigeh, et al
    • Journal Title

      Occupational Environmental Medicine

      Volume: 68 Issue: 3 Pages: 231-234

    • DOI

      10.1136/oem.2009.050419

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 妊娠初期における低鉛ばく露と新生児の発達2014

    • Author(s)
      ヴィージェモーセン、横山和仁、松川岳久、大谷勝己
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prenatal blood lead level and childhood neurobehavioral deficit2013

    • Author(s)
      Vigeh M., Yokoyama K., Matsukawa T., Shinohara A., Shahbazi A., Ohtani K
    • Organizer
      23rd Conference on Epidemiology in Occupational Health
    • Place of Presentation
      Netherland
    • Related Report
      2013 Annual Research Report
  • [Presentation] 妊娠女性における血中ヒ素の顕著な上昇に関して2013

    • Author(s)
      ヴィージェ・モーセン, 横山和仁, 松川岳久, 大谷勝己
    • Organizer
      第72回日本公衆衛生学会総会
    • Place of Presentation
      三重
    • Related Report
      2013 Annual Research Report
  • [Presentation] 妊娠中の血中低ヒ素が貧血のリスクを低減させうる2013

    • Author(s)
      ヴィージェ・モーセン, 松川岳久, 大谷勝己, 篠原厚子,横山和仁
    • Organizer
      第86回日本産業衛生学会
    • Place of Presentation
      松山
    • Related Report
      2013 Annual Research Report
  • [Presentation] 妊娠初期の血中マンガンは妊娠血圧の上昇を誘発する2012

    • Author(s)
      Vigeh M., Katsumi O., Kazuhito Y.,Atsuko S
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Increased blood lead in early pregnancy may adversely affect child development.2012

    • Author(s)
      Vigeh M., Yokoyama K., Matsukawa T., Shinohara A., Afshinrokh R. M.,Ohtani K2
    • Organizer
      International Conference on OccupationalHealth & Safety Summit
    • Place of Presentation
      Philadelphia
    • Related Report
      2012 Annual Research Report
  • [Presentation] 小児の鉛曝露に及ぼす社会経済因子の影響とその性差、および認知機能との関連-インドネシア共和国セルポン地域の調査-2012

    • Author(s)
      Iriani U. D., 松川岳久,横山和仁
    • Organizer
      第77回日本民族衛生学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Maternal Blood Lead may Reduce Mental Performance of Young Child.2012

    • Author(s)
      Vigeh M., Yokoyama K., Matsukawa T., Shinohara A.,Ohtani K
    • Organizer
      第24回産業神経・行動学研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Reproductive and developmental effects of lead and other trace metals : international collaboration studies between Japan, Iran and China2011

    • Author(s)
      Kazuhito Yokoyama, 他
    • Organizer
      13^<th> International Neurotoxicology Association Meeting and 11^<th> International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      Xi'an, China(シンポジスト)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Increase in blood heavy metals in early pregnancy indices hypertension in pregnant women2011

    • Author(s)
      Mohsen Vigeh, 他
    • Organizer
      47th Congress of the European Societies of Toxicology
    • Place of Presentation
      Paris, France
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lead and other trace metal effects on gestational hypertension2011

    • Author(s)
      Mohsen Vigeh, 他
    • Organizer
      22th International Conference on Epidemiology in Occupational Health
    • Place of Presentation
      Oxford, UK
    • Related Report
      2011 Annual Research Report
  • [Presentation] 妊娠初期における血中低鉛が妊娠合併症を誘発2011

    • Author(s)
      ヴィージェモーセン, 他
    • Organizer
      第84回日本産業衛生学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] 周産期におけるインスリン抵抗性と脂質代謝2011

    • Author(s)
      平山哲, 他
    • Organizer
      第58回日本臨床検査医学会学術集会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi