Molecular Epidemiology of HPV and HBV in men who have sex with men in South East Asia

• Project/Area Number: 23406032
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Infectious disease medicine
• Research Institution: Nagasaki University
• Principal Investigator: MIURA TOSHIYUKI 長崎大学, 熱帯医学研究所, 客員教授 (00296576)
• Co-Investigator(Kenkyū-buntansha): TACHIKAWA Ai 東京大学, 医科学研究所, 准教授 (10396880) ; ARIYOSHI Koya 長崎大学, 熱帯医学研究所, 教授 (30311400) ; KAWANA Kei 東京大学, 医学部附属病院, 准教授 (60311627) ; KUKIMOTO Iwao 国立感染症研究所, 病原体ゲノム解析研究センター, 室長 (70291127)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000); Fiscal Year 2011: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
• Keywords: 国際情報交換 / 肛門癌 / 男性同性愛者 / パピローマウイルス / HIV / 分子疫学 / 東南アジア / タイ王国

Research Abstract

Human Papilloma Virus (HPV) infection on anal epithelium is a risk for anal cancer. Anal cancer in men who have sex with men (MSM) would be substantial concern in developing countries where management of HIV infection has been improved significantly. We conducted anal cell cytology and HPV typing in MSM in Thailand; and found that atypical squamous cells were seen very frequently in this population. As expected, most MSM were infected with HPV on their anal cells. MSM with HIV infection carried HPV at significantly higher rate. Intriguingly, most MSM were infected with more than 3 different HPV subtypes, and many of them were subtype not covered by currently available HPV vaccine. This study will inform for future development of HPV vaccine for prevention of anal cell cancer in this geographical area.

Research Products

• [Presentation] Intraepithelial Lesion Associated with High-Risk Anal HPV Infection in MSM in Thailand (2013)
  • Author(s): Suwat Chariyalertsak, Darin Ruanpeng, Sumalee Siria u nkgul, Toshiyuki Miura, Natthapol Kosashunhanan, Patcharaphan Sugandhavesa, Pongpun Saokhieo, Antika Wongthanee. Anal Squamous
  • Organizer: 11th International Congress on AIDS in Asia and the Pacific (ICAAP 11)
  • Place of Presentation: Queen Sirikit Convention Center, Bangkok
• [Presentation] High Prevalence and Genotype Diversity of Anal HPV Infection among MSM in Northern Thailand (2013)
  • Author(s): Taweewat Supindham, Suwat Chariyalertsak, Utaiwan Utaipat, Toshiyuki Miura, Nuntisa Chotirosniramit, Pongpun Saokhieo, Radchanok Songsupa, Antika Wongthanee
  • Organizer: 11th International Congress on AIDS in Asia and the Pacific (ICAAP 11)
  • Place of Presentation: Queen Sirikit Convention Center, Bangkok
• [Presentation] Anal Squamous Intraepithelial Lesion Associated with High-Risk Anal HPV Infection in MSM in Thailand (2013)
  • Author(s): Suwat Chariyalertsak, Darin Ruanpeng, Sumalee Siria u nkgul, Toshiyuki Miura, Natthapol Kosashunhanan, Patcharaphan Sugandhavesa, Pongpun Saokhieo, Antika Wongthanee
  • Organizer: The 11th International Congress on AIDS in Asia and the Pacific
  • Place of Presentation: Queen Sirikit National Convention Center, Bangkok, Thailand
• [Presentation] High Prevalence and Genotype Diversity of Anal HPV Infection among MSM in Northern Thailand (2013)
  • Author(s): Taweewat Supindham, Suwat Chariyalertsak, Utaiwan Utaipat, Toshiyuki Miura, Nuntisa Chotirosniramit, Pongpun Saokhieo, Radchanok Songsupa, Antika Wongthanee
  • Organizer: The 11th International Congress on AIDS in Asia and the Pacific
  • Place of Presentation: Queen Sirikit National Convention Center, Bangkok, Thailand