| Project/Area Number |
23406033
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
NAKAYA Takaaki 京都府立医科大学, 医学(系)研究科(研究院), 教授 (80271633)
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| Co-Investigator(Kenkyū-buntansha) |
DAIDOJI Tomo 京都府立医科大学, 大学院・医学研究科, 助教 (80432433)
NAKAMURA Shota 大阪大学, 微生物病研究所, 助教 (90432434)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | ウイルス / メタゲノム / 次世代シーケンサー / タイ / タイ王国 / ハイスループットシーケンサー / 感染症 / タイ国 / ウイルス感染症 / ハイスループットシークエンサー / インフルエンザウイルス |
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| Research Abstract |
Newly developed next-generation sequencing (NGS) technologies can be used to generate large amounts of unbiased data (gigabases) in a single round of operation. So far, we have conducted a direct metagenomic diagnosis of virus infections in human clinical specimens using NGS in Japan. In this study, we collaborated with Osaka University and the Ministry of Public Health, Thailand, to conduct metagenomic research in order to identify causative agents of 36 clinical infectious cases caused by unknown pathogens in Thailand. Several rounds of high-throughput sequencing identified human pathogenic viruses, such as Picornaviridae, Paramyxoviridae, Coronaviridae, Herpesviridae, and Parvoviridae, in 23 specimens.
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