Clinical validation of VEGF as a potential novel biomarker of developing diabetes in postmenopausal women using Bangladeshi and Japanese population
| Project/Area Number |
23406037
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
KIMURA Sousuke 独立行政法人国立国際医療研究センター, その他部局等, その他 (30118450)
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| Co-Investigator(Kenkyū-buntansha) |
JESMIN Subrina 筑波大学, 医学医療系, 助教 (60374261)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
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| Keywords | 糖尿病 / 閉経期女性 / VFGF系 / 非エストロゲン系治療薬 / 閉経後 / バイオマーカー / リスク予知 / 臨床評価 / 日本 / バングラデシュ / イノベーション / Post menopause / Diabetes / Biomarker / Risk prediction / Clinical validation / Japan / Bangladesh / Innovation |
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| Research Abstract |
Vascular endothelial growth factor (VEGF) is a major vascular multi-factorial cytokine involved in all three types of vascular growth, namely angiogenesis, arteriogenesis and atherogenesis under physiological and pathological conditions. In the last decade, we have revealed that aberration in expression of VEGF in target organs is one of the key central mechanisms of microcirculatory-based organ dysfunctions in diabetes. In this study we confirmed clinically using Bangladeshi rural women that circulatory VEGF level is an important biomarker to detect the risk of developing diabetes in postmenopausal women. In addition, we also determined the circulatory level of reference VEGF value of Bangladeshi rural women investigating 1800 rural women.
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Report
(4 results)
Research Products
(117 results)
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[Journal Article] Screening for gestational diabetes mellitus and its prevalence in Bangladesh2014
Author(s)
Jesmin S, Akter S, Akashi H, Mamun AA, Rahman MA, Islam MM, Sohael F, Okazaki O, Moroi M, Kawano S, Mizutani T
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Journal Title
Diabetes Research and Clinical Practice
Volume: 103 (1)
Pages: 57-62
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[Journal Article] Disruption of components of vascular endothelial growth factor angiogenic signalling system in metabolic syndrome. Findings from a study conducted in rural Bangladeshi women2013
Author(s)
Jesmin S, Akter S, Rahman MM, Islam MM, Islam AM, Sultana SN, Mowa CN, Yamaguchi N, Okazaki O, Satoru K, Kimura S, Hiroe M, Mizutani T, Moroi M
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Journal Title
Thrombosis and Haemostasis
Volume: 109(4)
Pages: 696-705
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[Journal Article] Screening for gestational diabetes mellitus in Bogra sadar, Bogra Bangladesh2013
Author(s)
Jesmin S, Rahman A, Sohael F, Akter S, Islam MM, Khatun MT, Sultana SN, Mamun AA, Akashi H, Habib AKMA
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Journal Title
Journal of Shaheed Ziaur Rahman Medical College
Volume: 20(2)
Pages: 19-24
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[Journal Article] Metabolic syndrome among pre and post menopausal rural women in Bangladesh : result from a population based-study2013
Author(s)
Jesmin S, Islam AMS, Akter S, Islam MM, Sultana SN, Yamaguchi N, Okazaki O, Moroi M, Hiroe M, Kimura S, Watanabe T, Saturo K, Mizutani T
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Journal Title
BMC Research Notes
Volume: 6
Pages: 157-157
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[Journal Article] Prevalence of Metabolic Syndrome among Rural Bangladeshi Women2011
Author(s)
Jesmin S, Mia MS, Islam AMS, Islam R, Sultana SN, Zaedi S, Yamaguchi N, Okazaki O, Moroi M, Kimura S, Hiroe M
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Journal Title
Diabetes Research and Clinical Practice
Volume: 95(1)
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[Presentation] Potential association between disrupted VEGF angiogenic signaling and metabolic syndrome in Bangladeshi rural women2013
Author(s)
Jesmin S, Akter S, Shimojo N, Islam MM, Zaedi S, Yamaguchi N, Moroi M, Kimura S, Okazaki O, Hiroe M, Kawano S, Akashi H, Mizutani T
Organizer
2013 overseas scientific research Festa, Asahi-cho, Fucyu city
Place of Presentation
Tokyo, Japan
Year and Date
2013-06-29
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[Presentation] Comprehensive assessment of metabolic syndrome prevalence and its components among rural Bangladeshi women2013
Author(s)
Akter S, Jesmin S, Shimojo N, Islam MM, Zaedi S, Yamaguchi N, Moroi M, Kimura S, Okazaki O, Hiroe M, Kawano S, Akashi H, Mizutani T
Organizer
2013 overseas scientific research Festa, Asahi-cho, Fucyu city
Place of Presentation
Tokyo, Japan
Year and Date
2013-06-29
Related Report
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[Presentation] Disruption of components of vascular endothelial growth factor angiogenic signaling system in metabolic syndrome : Findings from a study conducted in rural Bangladeshi women2013
Author(s)
Jesmin S, Mamun AA, Akter S, Rahman MM, Islam MM, Khatun T, Rahman A, Sohael F, Sultana SN, Mizutani T
Organizer
World Diabetes Congress Melbourne 2013
Place of Presentation
Melbourne, Australia
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[Presentation] Potential association between circulatory level of endothelin-1 and metabolic syndrome in Bangladeshi rural women : a population-based cross-sectional study2013
Author(s)
Islam M, Jesmin S, Rahman A, Habib AKMA, Akter S, Shimojo N, Zaedi S, Yamaguchi N, Moroi M, Kimura S, Okazaki O, Hiroe M, Miyauchi T, Kawano S, Akashi H, MizutaniT
Organizer
The Thirteenth International Conference on Endothelin
Place of Presentation
Tokyo, Japan
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[Presentation] Higher circulatory level of endothelin-1 in hypertensive subjects screened through a cross sectional study in rural Bangladeshi women2013
Author(s)
Akter S, Jesmin S, Rahman A, Habib AKMA, Shimojo N, Islam M, Zaedi S, Yamaguchi N, Moroi M, Kimura S, Okazaki O, Miyauchi T, Kawano S, Akashi H, Mizutani T
Organizer
The Thirteenth International Conference on Endothelin
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Assessment of circulatory endothelin-1 level among pre- and post-menopausal rural women in Bangladesh : result from a population-based study2013
Author(s)
Khatutn T, Jesmin S, Rahman A, Habib AKMA, Shimojo N, Islam M, Zaedi S, Yamaguchi N, Moroi M, Kimura S, Okazaki O, Miyauchi T, Kawano S, Akashi H, Mizutani T
Organizer
The Thirteenth International Conference on Endothelin
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Selective endothelin (ET)-A receptor antagonist and dual ET-A/B receptor antagonist are effective in preventing the decrease in VEGF signaling and inadequate coronary collateral development in the diabetic hearts2013
Author(s)
Miyauchi Y, Jesmin S, Shimojo N, Maeda S, Sakai S, Yokota T, Zaedi S, Mizutani T, Homma S, Aonuma K, Miyauchi T
Organizer
The Thirteenth International Conference on Endothelin
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Endothelin antagonism and diabetic erectile dysfunction : Changes in VEGF and NO in type I diabetic penis and effects of endothelin antagonism2013
Author(s)
Zaedi S, Jesmin S, Shimojo N, Sakai S, Maeda S, Miyauchi Y, Yokota T, Mizutani T, Homma S, Aonuma K, Miyauchi T
Organizer
The Thirteenth International Conference on Endothelin
Place of Presentation
Tokyo, Japan
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[Presentation] Circulating levels of VEGF and its receptors, sVEGF-R1 and sVEGF-R2 in metabolic syndrome in Bangladeshi rural women2011
Author(s)
Jesmin S, Yamaguchi N, Islam MR, Mia MS, Islam AMS, Sultana SN, Zaedi S, Moroi M, Hiroe M
Organizer
The 1 st Asia Pacific Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy)
Place of Presentation
Shanghai, China
Related Report
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[Presentation] Prevalence of Metabolic Syndrome in Preand Post-Menopausal Rural Women of Bangladesh : Result from a Population-Based Study2011
Author(s)
Islam R, Jesmin S, Mia MS, Islam AMS, Sultana SN, Zaedi S, Rahman A, Yamaguchi N, Moroi M, Hiroe M, Kimura S
Organizer
The 1 st Asia Pacific Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy)
Place of Presentation
Shanghai, China
Related Report
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[Presentation] Prevalence of Metabolic Syndrome among Rural Bangladeshi Women2011
Author(s)
Islam R, Mia S, Rahman A, Sultana SN, Mahmood R, Islam AMS, Zaedi S, Yamaguchi N, Hiroe M, Kimura S, Jesmin S
Organizer
The 1 st Asia Pacific Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy)
Place of Presentation
Shanghai, China
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