| Project/Area Number |
23406037
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Obstetrics and gynecology
|
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
KIMURA Sousuke 独立行政法人国立国際医療研究センター, その他部局等, その他 (30118450)
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| Co-Investigator(Kenkyū-buntansha) |
JESMIN Subrina 筑波大学, 医学医療系, 助教 (60374261)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
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| Keywords | 糖尿病 / 閉経期女性 / VFGF系 / 非エストロゲン系治療薬 / 閉経後 / バイオマーカー / リスク予知 / 臨床評価 / 日本 / バングラデシュ / イノベーション / Post menopause / Diabetes / Biomarker / Risk prediction / Clinical validation / Japan / Bangladesh / Innovation |
|---|
| Research Abstract |
Vascular endothelial growth factor (VEGF) is a major vascular multi-factorial cytokine involved in all three types of vascular growth, namely angiogenesis, arteriogenesis and atherogenesis under physiological and pathological conditions. In the last decade, we have revealed that aberration in expression of VEGF in target organs is one of the key central mechanisms of microcirculatory-based organ dysfunctions in diabetes. In this study we confirmed clinically using Bangladeshi rural women that circulatory VEGF level is an important biomarker to detect the risk of developing diabetes in postmenopausal women. In addition, we also determined the circulatory level of reference VEGF value of Bangladeshi rural women investigating 1800 rural women.
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