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Statistical Issues in Complex Medical Product Development

Research Project

Project/Area Number 23500348
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Statistical science
Research InstitutionOsaka University

Principal Investigator

TOSHIMITSU Hamasaki  大阪大学, 医学(系)研究科(研究院), 准教授 (40379243)

Co-Investigator(Kenkyū-buntansha) SUGIMOTO Tomoyuki  弘前大学, 大学院・理工学研究科, 准教授 (70324829)
UESAKA Hiroyuki  大阪大学, 学内共同利用施設, 研究員 (60446250)
HAYASHI Kenichi  大阪大学, 大学院・医学系研究科, 助教 (70617274)
SUGITANI Toshifumi  大阪大学, 大学院・医学系研究科, 助教 (70626879)
SOZU Takashi  京都大学, 大学院・医学研究科, 准教授 (80408723)
山本 紘司  大阪大学, 医学部附属病院, 講師 (10548176)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords生物統計学 / 臨床試験 / 個別化医療 / 医薬品開発 / 国際共同臨床試験 / 多重エンドポイント / エンリッチメントデザイン / 国際研究者交流 / 部分集団解析 / Enrichmentデザイン / 国際共同試験
Research Abstract

The major objective of the research was on the challenging issues and recent methodological developments that may be applicable in the rapid growing area of research on innovative clinical trials design and analysis including adaptive designs, enrichment designs, analysis for multiple objectives. We provides efficient strategies for designing the clinical trials with multiple co-primary endpoints within group-sequential designs. In addition, we discuss adaptive enrichment method in confirmatory clinical trials, using method combing the partition testing and graphical approach. we also identify common practical issues in multi-regional clinical trials via case studies.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (65 results)

All 2014 2013 2012 2011 Other

All Journal Article (14 results) (of which Peer Reviewed: 10 results,  Open Access: 1 results) Presentation (49 results) (of which Invited: 10 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Sample size determination in group-sequential clinical trials with two co-primary endpoints2014

    • Author(s)
      Asakura, K., Hamasaki, T., Sugimoto, T., Hayashi, K., Evans, S., Sozu T
    • Journal Title

      Statistics in Medicine

      Volume: (First published online) Issue: 17 Pages: 2897-2913

    • DOI

      10.1002/sim.6154

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Statistical Issues in Clinical Trials with Multiple Primary Endpoints2013

    • Author(s)
      寒水孝司・杉本知之・濱崎俊光
    • Journal Title

      Japanese Journal of Biometrics

      Volume: 34 Issue: 1 Pages: 35-52

    • DOI

      10.5691/jjb.34.35

    • NAID

      10031194714

    • ISSN
      0918-4430, 2185-6494
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Partition testing in confirmatory adaptive designs with structured objectives2013

    • Author(s)
      Sugitani T, Hamasaki T, Hamada C
    • Journal Title

      Biometrical Journal

      Volume: 55 Issue: 3 Pages: 341-359

    • DOI

      10.1002/bimj.201200218

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A logrank test-based method for sizing clinical trials with two co-primary time-to-events endpoints2013

    • Author(s)
      Sugimoto T, Sozu T, Hamasaki T, Evans SR
    • Journal Title

      Biostatistics

      Volume: 14 Issue: 3 Pages: 409-421

    • DOI

      10.1093/biostatistics/kxs057

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sample size determination for clinical trials with co-primary outcomes. Exponential event-times2013

    • Author(s)
      Hamasaki T, Sugimoto T, Evans SR, Sozu T
    • Journal Title

      Pharmaceutical Statistics

      Volume: 12 Issue: 1 Pages: 28-34

    • DOI

      10.1002/pst.1545

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 非劣性試験の選択 : デザイン, モニタリング, 統計解析における問題2013

    • Author(s)
      濱崎俊光・Scott R Evans
    • Journal Title

      医学のあゆみ

      Volume: 244 Pages: 1212-1216

    • Related Report
      2013 Final Research Report
  • [Journal Article] 非劣性試験の選択: デザイン,モニタリング,統計解析における問題2013

    • Author(s)
      濱﨑俊光・Scott R Evans
    • Journal Title

      医学のあゆみ

      Volume: 244 Pages: 1212-1216

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
  • [Journal Article] Sample size determination in clinical trials with multiple co-primary endpoints including mixed continuous and binary variables2012

    • Author(s)
      Sozu T, Sugimoto T, Hamasaki T
    • Journal Title

      Biometrical Journal

      Volume: 54 Issue: 5 Pages: 716-729

    • DOI

      10.1002/bimj.201100221

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A convenient formula for sample size calculations in clinical trials with multiple co-primary continuous endpoints2012

    • Author(s)
      Sugimoto T, Sozu T, Hamasaki T
    • Journal Title

      Pharmaceutical Statistics

      Volume: 11 Issue: 2 Pages: 118-128

    • DOI

      10.1002/pst.505

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A simple modification of the Box and Cox transformation to scale stability and invariance2011

    • Author(s)
      Hamasaki T, Sugimoto T, Kim SY
    • Journal Title

      Journal of the Japanese Society of Computational Statistics

      Volume: 24 Issue: 1 Pages: 13-26

    • DOI

      10.5183/jjscs.1005001_187

    • NAID

      10030497138

    • ISSN
      0915-2350, 1881-1337
    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Note on Analysis of Ratio of Two Correlated Normal Variables2011

    • Author(s)
      朝倉こう子・上坂浩之・杉本知之・濱崎俊光
    • Journal Title

      Ouyou toukeigaku

      Volume: 40 Issue: 1 Pages: 53-71

    • DOI

      10.5023/jappstat.40.53

    • NAID

      10028209457

    • ISSN
      0285-0370, 1883-8081
    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sample size determination in superiority clinical trials with multiple co-primary correlated endpoints2011

    • Author(s)
      Sozu T, Sugimoto T, Hamasaki T
    • Journal Title

      Journal of Biopharmaceutical Statistics

      Volume: 21 Issue: 4 Pages: 650-668

    • DOI

      10.1080/10543406.2011.551329

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] History of clinical trials2011

    • Author(s)
      Hamasaki T
    • Journal Title

      In International Encyclopedia of Statistical Science

      Volume: vol.1 Pages: 254-256

    • Related Report
      2013 Final Research Report
  • [Journal Article] がんの生存率に対するマルコフモデルの適用について2011

    • Author(s)
      堀芽久美・大野ゆう子・清水佐知子・歌田真衣・早田みどり・濱崎俊光
    • Journal Title

      応用統計学会2011年度年会・講演予稿集

      Volume: - Pages: 112-113

    • Related Report
      2011 Research-status Report
  • [Presentation] Sizing clinical trials that compare two interventions using two time-to-event outcomes2014

    • Author(s)
      Ando Y, Hamasaki T, Sugimoto T, Evans SR, Ohno Y
    • Organizer
      2014 ENAR Spring Meeting
    • Place of Presentation
      Baltimore, Maryland, United States
    • Related Report
      2013 Annual Research Report
  • [Presentation] Sample size considerations when using two time-to-event outcomes for comparing two interventions in clinical trials2013

    • Author(s)
      Hamasaki T
    • Organizer
      Workshop on Statistics in Clinical Trials
    • Place of Presentation
      Institute of Statistical Science, Academia Sinica, Taiwan
    • Year and Date
      2013-09-26
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Invited
  • [Presentation] Sample size modification in group-sequential clinical trials with two co-primary endpoints2013

    • Author(s)
      Hamasaki T, Asakura K, Sugimoto T, Evans SR
    • Organizer
      Proceedings of Joint Meeting of the IASC Satellite Conference and 8th Conference of the Asian Regional Section of the IASC
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Graphical approach for adaptive group-sequential designs with dose selection at interim2013

    • Author(s)
      Sugitani T, Bretz F, Maurer W, Hamasaki T
    • Organizer
      The Ninth ICSA International Conference
    • Place of Presentation
      Hong Kong Baptist University, Hong Kong, China
    • Related Report
      2013 Final Research Report
  • [Presentation] Evans S. Sample size considerations when using multiple co-primary endpoints for comparing two interventions in clinical trials2013

    • Author(s)
      Hamasaki T, Asakura K, Sugimoto T
    • Organizer
      The Ninth ICSA International Conference
    • Place of Presentation
      Hong Kong Baptist University, Hong Kong, China
    • Related Report
      2013 Final Research Report
  • [Presentation] Sample size evaluation in group sequential designs for clinical trials with two continuous endpoints as co-primary contrasts2013

    • Author(s)
      Asakura K, Hayashi K, Sugimoto T, Sozu T, Hamasaki T
    • Organizer
      Joint Statistical Meetings 2013
    • Place of Presentation
      Montreal, Quebec, Canada
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] A comparison of group sequential strategies for three-arm non-inferiority trial2013

    • Author(s)
      Ochiai T, Sugitani T, Ohno Y, Hamasaki T
    • Organizer
      Joint Statistical Meetings 2013
    • Place of Presentation
      Montreal, Quebec, Canada
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Sample size considerations when using two time-to-event outcomes for comparing two interventions in clinical trials2013

    • Author(s)
      Sugimoto T, Hamasaki T, Sozu T, Evans SR
    • Organizer
      Joint Statistical Meetings 2013
    • Place of Presentation
      Montr?al, Qu?bec, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] Sample size considerations in complex clinical trials2013

    • Author(s)
      Hamasaki T, Sozu T, Sugimoto T, Evans SR
    • Organizer
      The 8th International Conference on Multiple Comparison Procedures
    • Place of Presentation
      University of Southampton, UK
    • Related Report
      2013 Final Research Report
  • [Presentation] Sequentially rejective graphical procedures in adaptive treatment selection designs2013

    • Author(s)
      Sugitani T, Bretz F, Maurer W, Hamasaki T
    • Organizer
      The 8th International Conference on Multiple Comparison Procedures
    • Place of Presentation
      University of Southampton, United Kingdom
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Mid-course sample size modification in group-sequential designs with co-primary endpoints2013

    • Author(s)
      Aasakura K, Hamasaki T, Evans SR, Sugimoto T
    • Organizer
      Joint Conference by the International Chinese Statistical Association (ICSA) and the International Society for Biopharmaceutical Statistics (ISBS)
    • Place of Presentation
      Washington DC, United States
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Invited
  • [Presentation] Sample size evaluation in clinical trials with co-primary endpoints2013

    • Author(s)
      Hamasaki T, Sozu T, Sugimoto T, Evans SR
    • Organizer
      2013 ENAR Spring Meeting
    • Place of Presentation
      Orlando, Florida, United States
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Graphical approach for adaptive group-sequential designs with dose selection at interim2013

    • Author(s)
      Sugitani T, Bretz F, Maurer W, Hamasaki T
    • Organizer
      The Ninth ICSA International Conference
    • Place of Presentation
      Hong Kong Baptist University, Hong Kong, China,
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Sample size considerations when using multiple co-primary endpoints for comparing two interventions in clinical trials2013

    • Author(s)
      Hamasaki T, Asakura K, Sugimoto T, Evans S
    • Organizer
      The Ninth ICSA International Conference
    • Place of Presentation
      Hong Kong Baptist University, Hong Kong, China,
    • Related Report
      2013 Annual Research Report
  • [Presentation] Sample size modification in group-sequential clinical trials with two co-primary endpoints2013

    • Author(s)
      Hamasaki T, Asakura K, Sugimoto T, Evans SR.
    • Organizer
      Joint Meeting of the IASC Satellite Conference and 8th Conference of the Asian Regional Section of the IASC
    • Place of Presentation
      eoul, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Sample size considerations when using two time-to-event outcomes for comparing two interventions in clinical trials2013

    • Author(s)
      Sugimoto T, Hamasaki T, Sozu T, Evans SR
    • Organizer
      Joint Statistical Meetings 2013
    • Place of Presentation
      Montreal, Quebec, Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] Sample size considerations in complex clinical trials2013

    • Author(s)
      Hamasaki T, Sozu T, Sugimoto T, Evans SR
    • Organizer
      The 8th International Conference on Multiple Comparison Procedures
    • Place of Presentation
      University of Southampton, United Kingdom
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Power and sample size determination in clinical trials with multiple correlated endpoints2012

    • Author(s)
      Hamasaki T, Sozu T, Sugimoto T, Evans SR
    • Organizer
      Advances in Clinical Trial Statistics
    • Place of Presentation
      National Health Research Institute, Taiwan
    • Year and Date
      2012-11-20
    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Invited
  • [Presentation] 用量探索試験における適応的ゲートキーピング法2012

    • Author(s)
      杉谷利文・浜田知久馬・濱崎俊光
    • Organizer
      2012年度統計関連学会連合大会
    • Place of Presentation
      北海道大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 複数の主要評価変数の費用効率を考慮した臨床試験のデザイン2012

    • Author(s)
      寒水孝司・杉本知之・濱崎俊光
    • Organizer
      2012年度統計関連学会連合大会
    • Place of Presentation
      北海道大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Sample size determination in group sequential trials with two co-primary endpoints2012

    • Author(s)
      Asakura K, Hayashi K, Sugimoto T, Sozu T, Hamasaki T
    • Organizer
      The XXVIth International Biometric Conference
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Sample size determination in clinical trials with multiple correlated endpoints2012

    • Author(s)
      Hamasaki T, Sozu T, Sugimoto T, Evans SR
    • Organizer
      Joint Statistical Meetings 2012
    • Place of Presentation
      San Diego, United States
    • Related Report
      2013 Final Research Report
  • [Presentation] 二つの主要変数をもつ群逐次試験の標本サイズの設計と評価2012

    • Author(s)
      朝倉こう子・林 賢一・杉本知之・寒水孝司・濱崎俊光
    • Organizer
      日本計量生物学会2012年度年会・講演予稿集
    • Place of Presentation
      統計数理研究所, 東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Sample size determination in clinical trials with two correlated time-to-events endpoints as primary contrasts2012

    • Author(s)
      Hamasaki T, Sugimoto T, Sozu T, Evans SR
    • Organizer
      The 6th Annual FDA-DIA Statistics Forum
    • Place of Presentation
      Bethesda, United States
    • Related Report
      2013 Final Research Report
  • [Presentation] Sample size determination in clinical trials with multiple binary relative risks2012

    • Author(s)
      Hamasaki T, Evans SR, Sugimoto T, Sozu T
    • Organizer
      2012 ENAR Spring Meeting
    • Place of Presentation
      Washington DC, United States
    • Related Report
      2013 Final Research Report
  • [Presentation] Adjustment methods for testing co-primary endpoints in clinical trials2012

    • Author(s)
      Sozu T, Hamasaki T
    • Organizer
      East Asia Regional Biometric Conference 2012
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] An adaptive graphical approach for testing several doses in seamless phase II/III clinical trials with a-priori ordered efficacy endpoints2012

    • Author(s)
      Sugitami T, Hamada C, Hamasaki T
    • Organizer
      East Asia Regional Biometric Conference 2012
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Sample size determination in clinical trials with two correlated time-to-events endpoints as primary contrasts2012

    • Author(s)
      Hamasaki T, Sugimoto T, Sozu T, Evans SR
    • Organizer
      The 6th Annual FDA-DIA Statistics Forum
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Adjustment methods for testing co-primary endpoints in clinical trials2012

    • Author(s)
      Sozu T, Hamasaki T
    • Organizer
      East Asia Regional Biometric Conference 2012(ポスター発表)
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Research-status Report
  • [Presentation] Design and data monitoring of clinical trials with co-primary benefit : risk endpoints using prediction2011

    • Author(s)
      Evans SR. Hamasaki T, Hayashi K
    • Organizer
      Joint Meeting of the 2011 Taipei International Statistical Symposium and the 7th Conference of Asian Regional Section of the IASC
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2013 Final Research Report
  • [Presentation] Sample size determination for clinical trials with two correlated time-to-event co-primary endpoints2011

    • Author(s)
      Hamasaki T, Evans SR, Sugimoto T, Sozu T
    • Organizer
      Joint Meeting of the 2011 Taipei International Statistical Symposium and the 7th Conference of Asian Regional Section of the IASC
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Sample size determination in clinical trials with multiple correlated endpoints2011

    • Author(s)
      Sozu T, Hamasaki T, Sugimoto, T
    • Organizer
      Joint Meeting of the 2011 Taipei International Statistical Symposium and the 7th Conference of Asian Regional Section of the IASC
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2013 Final Research Report
  • [Presentation] 二つの主要変数をもつ群逐次試験の標本サイズの設計2011

    • Author(s)
      朝倉こう子・林 賢一・杉本知之・寒水孝司・濱崎俊光
    • Organizer
      2011年度統計関連学会連合大会
    • Place of Presentation
      九州大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 複数の主要評価変数をもつ臨床試験における標本サイズの公式2011

    • Author(s)
      寒水孝司・杉本知之・濱崎俊光
    • Organizer
      2011年度統計関連学会連合大会
    • Place of Presentation
      九州大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Sample size determination in clinical trials with two correlated co-primary time-to-event endpoints2011

    • Author(s)
      Sugimoto T, Hamasaki T, Sozu T
    • Organizer
      The 7th International Conference on Multiple Comparison Procedures
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] がんの生存率に対するマルコフモデルの適用について2011

    • Author(s)
      堀芽久美・大野ゆう子・清水佐知子・歌田真衣・早田みどり・濱崎俊光
    • Organizer
      応用統計学会2011年度年会・講演予稿集
    • Place of Presentation
      大阪大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Evans SR. Power and sample size determination for clinical trials with two correlated binary relative risks2011

    • Author(s)
      Hamasaki T
    • Organizer
      The 2011 International Conference on Applied Statistics
    • Place of Presentation
      National Taipei University, Taipei, Taiwan
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Design and data monitoring of clinical trials with co-primary benefit:risk endpoints using prediction2011

    • Author(s)
      Evans S. Hamasaki T, Hayashi K
    • Organizer
      Joint Meeting of the 2011 Taipei International Statistical Symposium and the 7th Conference of Asian Regional Section of the IASC
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2011 Research-status Report
  • [Presentation] Sample size determination in clinical trials with multiple correlated endpoints2011

    • Author(s)
      Sozu T, Hamasaki T, Sugimoto, T
    • Organizer
      Joint Meeting of the 2011 Taipei International Statistical Symposium and the 7th Conference of Asian Regional Section of the IASC(招待講演)
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2011 Research-status Report
  • [Presentation] Power and sample size determination for clinical trials with two correlated binary relative risks2011

    • Author(s)
      Hamasaki T, Evans S
    • Organizer
      The 2011 International Conference on Applied Statistics(招待講演)
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2011 Research-status Report
  • [Presentation] 二つの主要変数をもつ群逐次試験の標本サイズの設計2011

    • Author(s)
      朝倉こう子・林 賢一・杉本知之・寒水孝司・濱崎俊光
    • Organizer
      2011年度統計関連学会連合大会
    • Place of Presentation
      九州大学(福岡県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 複数の主要評価変数をもつ臨床試験における標本サイズの公式2011

    • Author(s)
      寒水孝司・杉本知之・濱崎俊光
    • Organizer
      2011年度統計関連学会連合大会
    • Place of Presentation
      九州大学(福岡県)
    • Related Report
      2011 Research-status Report
  • [Presentation] がんの生存率に対するマルコフモデルの適用について2011

    • Author(s)
      堀芽久美・大野ゆう子・清水佐知子・歌田真衣・早田みどり・濱崎俊光
    • Organizer
      応用統計学会2011年度年会
    • Place of Presentation
      大阪大学(大阪府)
    • Related Report
      2011 Research-status Report
  • [Presentation] Sample size evaluation in clinical trials with co-primary endpoints

    • Author(s)
      Hamasaki T, Sozu T, Sugimoto T, Evans SR
    • Organizer
      ENAR 2013 Spring Meeting
    • Place of Presentation
      Orlando, Florida, USA
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Sample size determination in clinical trials with multiple correlated endpoints

    • Author(s)
      Hamasaki T, Sozu T, Sugimoto T, Evans SR
    • Organizer
      Joint Statistical Meetings 2012
    • Place of Presentation
      San Diego, California, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Power and Sample Size Determination in Clinical Trials with Two-Correlated Relative Risks

    • Author(s)
      Hamasaki T, Evans SR, Sugimoto T, Sozu T
    • Organizer
      ENAR 2012 Spring Meeting
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 用量探索試験における適応的ゲートキーピング法

    • Author(s)
      杉谷利文・浜田知久馬・濱﨑俊光
    • Organizer
      2012年度統計関連学会連合大会
    • Place of Presentation
      北海道大学,北海道
    • Related Report
      2012 Research-status Report
  • [Presentation] 複数の主要評価変数の費用効率を考慮した臨床試験のデザイン

    • Author(s)
      寒水孝司・杉本知之・濱﨑俊光
    • Organizer
      2012年度統計関連学会連合大会
    • Place of Presentation
      北海道大学,北海道
    • Related Report
      2012 Research-status Report
  • [Presentation] 二つの主要変数をもつ群逐次試験の標本サイズの設計と評価

    • Author(s)
      朝倉こう子・林 賢一・杉本知之・寒水孝司・濱﨑俊光
    • Organizer
      日本計量生物学会 2012年度年会
    • Place of Presentation
      統計数理研究所, 立川,東京
    • Related Report
      2012 Research-status Report
  • [Remarks] 研究内容

    • URL

      http://www.medstat.med.osaka-u.ac.jp/research.html

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 筋トーヌス計測装置2013

    • Inventor(s)
      佐古田三郎, 濱崎俊光, 遠藤卓行
    • Industrial Property Rights Holder
      佐古田三郎, 濱崎俊光, 遠藤卓行
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2013-08-16
    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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