Bifurcation analysis of mathematical cardiac models and its application to suppressing alternans
| Project/Area Number |
23500367
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Research Collaborator |
YAZAWA Toru 首都大学, 東京都市教養学部, 助教
HORIKAWA Yo 香川大学, 工学部, 教授
TANAKA Yoshio 産業技術総合研究所四国センター, 主任研究員
HASHIMOTO Naoyuki 香川大学, 工学部
TADA Junya 香川大学, 工学部
TARUMOTO Tomoya 香川大学, 工学部
TSUYAMA Yusuke 香川大学, 工学部
KATAOKA Hiroaki 香川大学, 工学部
FUJIMOTO Kenichi 香川大学, 大学連携e-Learning教育支援センター四国, 助教
IOKA Eri 青山学院大学, 理工学部, 助教
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 分岐 / システムバイオロジー / 交互脈 / 数理モデル / 不整脈 / 心臓数理モデル |
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| Outline of Final Research Achievements |
In this study, we clarify the mechanism of generating alternans in mathematical cardiac models. Two systems are considered: (1) the system of making sustainable periodic oscillations and (2) the system of the ventricular muscle with ideal inputs. As a result, we obtain that the alternans occurs through abnormalities of the conductivity and the reversal potentials of the potassium ion, and it triggers cardiac death.
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Report
(5 results)
Research Products
(31 results)
