| Project/Area Number |
23500368
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
MATSUSHIMA NORIO 札幌医科大学, 医療人育成センター, 教授 (60137403)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ロイシンリッチリピート / タンデムリピート / 水平進化 / ロシンリッチリピート / Non-canonical LRR / 国際研究者交流(モンゴル） / 国際研究者交流(米国） / 国際情報交流、モンゴル / 国際情報交流、米国 |
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| Research Abstract |
Leucine rich repeats (LRRs) are present in over 20,000 proteins from viruses to eukaryotes. Two to sixty-two LRRs occur in tandem. Most LRR proteins are involved in protein, ligand and in protein, protein interactions; these include the plant immune response and the mammalian innate immune response. Each repeat with 20-30 residues can be divided into a highly conserved segment and a variable segment. Eight classes have been recognized.
Plant specific LRRs (class: PS-LRR) had previously been recognized in only plant proteins. However, we find that PS-LRRs are also present in twenty proteins from eleven bacterial species. We indicate that horizontal gene transfer of genes/gene fragments encoding PS-LRR domains occurred between bacteria and plants, as opposed to descent from a common ancestor. Also we find novel LRRs that were unrecognized until now. The novel LRR domains are present over three hundred proteins including fungal ECM33 protein from unicellular eukaryotes and bacteria.
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