Influence of ambient neuromodulators on learning through hetero-GPCR interplay
| Project/Area Number |
23500384
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | University of Toyama |
|---|
Principal Investigator |
TABATA Toshihide 富山大学, 大学院理工学研究部(工学), 准教授 (80303270)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KAMIKUBO Yuji 順天堂大学, 医学部, 助教 (80509670)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | Ｇタンパク質 / シナプス可塑性 / ニューロン / 受容体 / 学習 / 小脳 / 生理学 / 神経科学 / Gタンパク質 |
|---|
| Research Abstract |
In cerebellar Purkinje cells, B-type gamma-aminobutyric acid receptor (GABAbR) and type-1 adenosine receptor (A1R) are suggested to modulate type-1 metabotropic glutamate receptor (mGluR1) whose intracellular signaling triggers induction of cerebellar long-term depression (LTD). Using a machine vision-based optokinetic reflex (OKR) measuring system, we found that in mice, cerebellar injection of a GABAbR agonist facilitated OKR adaptation, a cerebellar LTD-dependent learning. Moreover, using in-vitro preparations, we found that A1R interacted with mGluR1 via its C-terminus and that A1R activation suppressed the LTD of Purkinje cell's glutamate-responsiveness by lowering mGluR1's ligand-sensitivity in a G protein-independent manner. The hetero-G protein-coupled receptor interplay may influence central synaptic plasticity and learning.
|
Report
(4 results)
Research Products
(42 results)
-
[Journal Article] The synaptic targeting of mGluR1 by its carboxyl-terminal domain Is crucial for cerebellar function2014
Author(s)
Yoshiaki Ohtani, Mariko Miyata, Kouichi Hashimoto, Toshihide Tabata, Yasushi Kishimoto, Masahiro Fukaya, Daisuke Kase, Hidetoshi Kassai, Kazuki Nakao, Tatsumi Hirata, Masahiko Watanabe, Masanobu Kano, Atsu Aiba
-
Journal Title
Journal of Neuroscience
Volume: 34
Issue: 7
Pages: 2702-2712
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Glycine/Serine Polymorphism at Position 38 Influences KCNE1 Subunit’s Modulatory Actions on Rapid and Slow Delayed Rectifier K<sup>+</sup> Currents2014
Author(s)
Yoshiaki Yamaguchi, Kohki Nishide, Mario Kato, Yukiko Hata, Koichi Mizumaki, Koshi Kinoshita, Yuki Nonobe, Toshihide Tabata, Tamotsu Sakamoto, Naoya Kataoka, Yosuke Nakatani, Fukiko Ichida, Hisashi Mori, Kenkichi Fukurotani, Hiroshi Inoue, MD, Naoki Nishida
-
Journal Title
Circulation Journal
Volume: 78
Issue: 3
Pages: 610-618
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed
-
[Journal Article] Identification and characterization of a novel genetic mutation with prolonged QT syndrome in an unexplained postoperative death2014
Author(s)
Yukiko Hata, Hisashi Mori, Ayumi Tanaka, Yosuke Fujita, Takeshi Shimomura, Toshihide Tabata, Koshi Kinoshita, Yoshiaki Yamaguchi, Fukiko Ichida, Yoshihiko Kominato, Noriaki Ikeda, Naoki Nishida
-
Journal Title
International Journal of Legal Medicine
Volume: 128
Issue: 1
Pages: 105-115
DOI
Related Report
Peer Reviewed
-
[Journal Article] A590T mutation in KCNQ1 C-terminal helix D decreases IKs channel trafficking and function but not Yotiao interaction2014
Author(s)
Koshi Kinoshita, Takuto Komatsu, Kohki Nishide, Yukiko Hata, Nozomi Hisajima, Hiroyuki Takahashi, Katsuya Kimoto, Kei Aonuma, Eikichi Tsushima, Toshihide Tabata, Tomoyuki Yoshida, Hisashi Mori, Kunihiro Nishida, Yoshiaki Yamaguchi, Fukiko Ichida, Kenkichi Fukurotani, Hiroshi Inoue, Naoki Nishida
-
Journal Title
Journal of Molecular and Cellular Cardiology
Volume: 72C (online)
Pages: 273-280
Related Report
Peer Reviewed
-
-
[Journal Article] Functional cooperation of metabotropic adenosine and glutamate receptors regulates postsynaptic plasticity in the cerebellum.2013
Author(s)
Kamikubo, Y., Shimomura, T., Fujita, Y., Tabata, T., Kashiyama, T., Sakurai, T., Fukurotani, K., Kano, M.
-
Journal Title
J. Neurosci
Volume: 33
Issue: 47
Pages: 18661-18671
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Characterization of a novel mutant KCNQ1 channel subunit lacking a large part of the C-terminal domain2013
Author(s)
Katsuya Kimoto, Koshi Kinoshita, Tomoki Yokoyama, Yukiko Hata, Takuto Komatsu, Eikichi Tsushima, Kohki Nishide, Yoshiaki Yamaguchi, Koichi Mizumaki, Toshihide Tabata, Hiroshi Inoue, Naoki Nishida, Kenkichi Fukurotani
-
Journal Title
Biochemical and Biophysical Research Communications
Volume: 440
Issue: 2
Pages: 283-288
DOI
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] A novel missense mutation causing a G487R substitution in the S2-S3 loop of human ether-a-go-go-related gene channel2012
Author(s)
Kinoshita K, Yamaguchi Y, Nishide K, Kimoto K, Nonobe Y, Fujita A, Asano K, Tabata T, Mori H, Inoue H, Hata Y, Fukurotani K, Nishida N
-
Journal Title
J Cardiovasc Electrophysiol
Volume: 23
Issue: 11
Pages: 1246-1253
DOI
Related Report
Peer Reviewed
-
-
-
[Presentation] Functional Characterization of KCNQ1 Channel Subunit With an A590T Mutation2013
Author(s)
Koshi Kinoshita, Katsuya Kimoto, Takuto Komatsu, Kohki Nishide, Toshihide Tabata, Fukiko Ichida, Yoshiaki Yamaguchi, Kunihiro Nishida, Hiroshi Inoue, Yukiko Hata, Naoki Nishida
Organizer
Basic Cardiovascular Sciences 2013 Scientific Sessions
Place of Presentation
Las Vegas, USA
Related Report
-
[Presentation] Functional characterization of KCNQ1 channel subunit with an A590T mutation2013
Author(s)
Kinoshita K, Kimoto K, Komatsu T, Nishide K, Tabata T, Ichida F, Yamaguchi Y, Nishida K, Inoue H, Hata Y, Nishida N
Organizer
Basic Cardiovascular Sciences 2013 Scientific Sessions
Place of Presentation
Las Vegas, Nevada, USA
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
