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Roles of scaffold protein JSAP in axonal transport

Research Project

Project/Area Number 23500385
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neuroscience in general
Research InstitutionKanazawa University

Principal Investigator

YOSHIOKA Katsuji  金沢大学, がん進展制御研究所, 教授 (60200937)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsシグナル伝達 / 足場タンパク質 / MAPキナーゼ / マウス / 軸索 / JNK / 神経 / 神経変性
Research Abstract

Axonal transport is essential for neuronal development and function, and disrupted axonal transport is an important pathophysiological factor in a variety of neurodegenerative diseases. We suggest that scaffold protein JSAP may function as a positive regulator of kinesin-dependent axonal transport to prevent neuronal degeneration.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2014 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (16 results) Remarks (2 results)

  • [Journal Article] The scaffold protein JLP plays a key role in regulating ultraviolet B-induced apoptosis in mice2014

    • Author(s)
      Enkhtuya R, Sato T, Wakasugi M, Tuvshintugs B, Miyata H, Sakurai T, Matsunaga T, Yoshioka K
    • Journal Title

      Genes Cells

      Volume: 19 Pages: 350-358

    • NAID

      120005440448

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The scaffold protein JLP plays a key role in regulating ultraviolet B-induced apoptosis in mice2014

    • Author(s)
      Enkhtuya R, Sato T, Wakasugi M, Tuvshintugs B, Miyata H, Sakurai T, Matsunaga T, Yoshioka K.
    • Journal Title

      Genes to Cells

      Volume: 19 Issue: 4 Pages: 350-358

    • DOI

      10.1111/gtc.12135

    • NAID

      120005440448

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SCF β TrCP mediates stress-activated MAP kinase-induced Cdc25B degradation.2014

    • Author(s)
      Uchida, S, et al.
    • Journal Title

      J Cell Sci.

      Volume: 124 Issue: 16 Pages: 2816-2825

    • DOI

      10.1242/jcs.083931

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Displays of paternal mouse pup retrieval following communicative interaction with maternal mates2013

    • Author(s)
      Liu HX, Lopatina O, Higashida C, Fujimoto H, Akther S, Inzhutova A, Liang M, Zhong J, Tsuji T, Yoshihara T, Sumi K, Ishiyama M, Ma WJ, Ozaki M, Yagitani S, Yokoyama S, Mukaida N, Sakurai T, Hori O, Yoshioka K, Hirao A, Kato Y, Ishihara K, Kato I, Okamoto H, Cherepanov SM, Salmina AB, Hirai H, Asano M, Brown DA, Nagano I, Higashida H
    • Journal Title

      Nat. Commun

      Volume: 4 Pages: 1346-1346

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Displays of paternal mouse pup retrieval following communicative interaction with maternal mates2013

    • Author(s)
      Liu, H-X., Lopatina, O., Higashida, C., Fujimoto, H., Akther, S., Inzhutova, A., Liang, M., Zhong, J., Tsuji, T., Yoshihara, T., Sumi, K., Ishiyama, M., Ma, W-J., Ozaki, M., Yagitani, S., Yokoyama, S., Mukaida, N., Sakurai, T., Hori, O., Yoshioka, K., Hirao, A., Kato, Y., Ishihara, K., Kato, I., Okamoto, H., Cherepanov, S.M., Salmina, A.B., Hirai, H., Asano, M., Brown, D.A., Nagano, I., and Higashida, H.
    • Journal Title

      Nat. Commun

      Volume: 4 Issue: 1 Pages: 1346-1346

    • DOI

      10.1038/ncomms2336

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Human microRNA-1245 down-regulates the NKG2D receptor in natural killer cells and impairs NKG2D-mediated functions2012

    • Author(s)
      Espinoza JL, Takami A, Yoshioka K, Nakata K, Sato T, Kasahara Y, Nakao S
    • Journal Title

      Haematologica

      Volume: 97 Pages: 1295-1303

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Role of the scaffolding protein JLP in UVB-induced apoptosis2013

    • Author(s)
      Enkhtuya R, Tuvshintugs B, Miyata H, Sato T, Yoshioka K
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2013-12-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of Gli1 transcription activator in the metastasis of melanoma2013

    • Author(s)
      Gunarta IK, Sato T, Endo Y, Li R, Nishiuchi T, Yamada Y, Yoshioka K
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2013-12-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of the scaffolding protein JLP in UVB-induced apoptosis2013

    • Author(s)
      Enkhtuya, R., Tuvshintugs, B., Miyata, H., Sato, T., Yoshioka, K
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Role of Gli1 transcription activator in the metastasis of melanoma2013

    • Author(s)
      Gunarta, I.K., Sato, T., Endo, Y., Li, R., Nishiuchi, T., Yamada, Y., Yoshioka, K.
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Role of the MAP kinase scaffold proteins JSAP1 and JLP in cerebellar Purkinje cells2012

    • Author(s)
      Ishikawa M, Sato T, Ohta M, Yoshioka K
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡(福岡県)
    • Year and Date
      2012-12-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of JNK signaling pathway in the regulation of stability of transcription factor Gli12012

    • Author(s)
      Tuvshintugs B, Sato T, Yoshioka K
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡(福岡県)
    • Year and Date
      2012-12-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional analysis of the MAP kinase scaffold proteins JSAP1 and JLP in cortical neurons2012

    • Author(s)
      Mochizuki M, Sato T, Yoshioka K
    • Organizer
      第11回アジア太平洋神経化学会大会・第55回日本神経化学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2012-09-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of the MAP kinase scaffold proteins JSAP1 and JLP in cerebellar Purkinje cells2012

    • Author(s)
      石川桃絵
    • Organizer
      第35回 日本分子生物学会年会
    • Place of Presentation
      福岡(福岡県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Functional analysis of the MAP kinase scaffold proteins JSAP1 and JLP in cortical neurons2012

    • Author(s)
      望月美希
    • Organizer
      第11回アジア太平洋神経化学会大会・第55回日本神経化学会大会
    • Place of Presentation
      神戸(兵庫県)
    • Related Report
      2012 Research-status Report
  • [Presentation] FGF/JSAP1/JNK signaling accelerates degradation of Gli1 and reduces its transcriptional activity2011

    • Author(s)
      佐藤時春, Tuvshintugs B., Enkhbat A., 李蓉, 善岡克次
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of the MAP kinase scaffold proteins JSAP1 and JLP in cortical neurons2011

    • Author(s)
      望月美希, 佐藤時春, 善岡克次
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Cross-talk between JSAP1/JNK and Shh/Gli signaling pathway during the differentiation of cerebellar granule cell progenitors2011

    • Author(s)
      佐藤時春, Tuvshintugs B., 善岡克次
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Subcellular localization of the scaffold protein JSAP1 during the differentiation of cerebellar granule cell precursors2011

    • Author(s)
      佐藤時春, Enkhbat A., Tuvshintugs B., 善岡克次
    • Organizer
      日本分子生物学会第11回春期シンポジウム
    • Place of Presentation
      石川県音楽堂(石川県)
    • Year and Date
      2011-05-26
    • Related Report
      2013 Final Research Report
  • [Presentation] FGF/JSAP1/JNK signaling accelerates degradation of Gli1 and reduces its transcriptional activity2011

    • Author(s)
      佐藤時春
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Role of the MAP kinase scaffold proteins JSAP1 and JLP in cortical neurons2011

    • Author(s)
      望月美希
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Subcellular localization of the scaffold protein JSAP1 during the differentiation of cerebellar granule cell precursors2011

    • Author(s)
      佐藤時春
    • Organizer
      日本分子生物学会第11回春期シンポジウム
    • Place of Presentation
      石川県音楽堂(石川県)
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.kanazawa-u.ac.jp/~ganken/department/mccb/03.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 金沢大学がん進展制御研究所 シグナル伝達研究分野

    • URL

      http://www.kanazawa-u.ac.jp/~ganken/yoshiokaHP/index.html

    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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